Does low dose internal radiation increase lifespan?

Health Physics

Volumn 86, Issue 6, 2004, Pages 629-632

  Lloyd, Ray D ^a   Taylor, Glenn N ^a   Miller, Scott C ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Dogs; Dose, low; Internal dose; Mortality

Indexed keywords

AMERICIUM 241; PLUTONIUM 239; RADIOISOTOPE; RADON; RADON 226; RADON 228; STRONTIUM 90; THORIUM; THORIUM 228; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BONE CANCER; CONTROLLED STUDY; DOG; GRAND MAL EPILEPSY; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; SURVIVAL; UNITED STATES;

ANIMALS; BODY BURDEN; BONE NEOPLASMS; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; INJECTIONS; LONGEVITY; MALE; MODELS, BIOLOGICAL; NEOPLASMS, RADIATION-INDUCED; PROPORTIONAL HAZARDS MODELS; RADIATION DOSAGE; RADIOISOTOPES; RADIOMETRY; REFERENCE VALUES; RISK ASSESSMENT; SEX DISTRIBUTION; SURVIVAL ANALYSIS; SURVIVAL RATE;

ANIMALIA; CANIS FAMILIARIS;

EID: 2442653985     PISSN: 00179078     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004032-200406000-00009     Document Type: Article

References (33)

1. Adelstein SJ. Biologic responses to low doses of ionizing radiation: adaptive responses versus bystander effect. J Nucl Med 44:125; 2003.
2. Bruenger FW, Lloyd RD, Miller SC. The influence of age at time of exposure to 226Ra or 239Pu on distribution, retention, postinjection survival and tumor induction in beagle dogs. Radiat Res 125:248-256; 1991a.
3. Bruenger FW, Miller SC, Lloyd RD. A comparison of the natural survival of beagle dogs injected intravenously with low levels of 239Pu, 228Th, 226Ra, 228Ra and 90Sr. Radiat Res 126:328-337; 1991b.
4. Bruenger FW, Lloyd RD, Miller SC, Taylor GN, Angus W, Huth DA. Occurrence of mammary tumors in beagles given radium-226. Radiat Res 138:423-434; 1994.
5. Calabreze EJ, Baldwin LA, Holland CD. Hormesis: a highly generalizable and reproducible phenomenon with important implications for risk assessment. Risk Anal 19:261-281; 1999.
6. Calabreze EJ. Baldwin LA. Defining hormesis. Hum Exp Toxicol 21:91-97; 2002.
7. Dougherty TF, Stover BJ, Dougherty JH, Jee WSS, Mays CW, Rehfeld CE, Christensen WR, Goldthorpe HC. Studies of the biological effects of Ra226, Pu239, Ra228 (MsTh), Th228 (RdTh) and Sr90 in adult beagles. Radiat Res 17:625-681; 1962.
8. Feinendegen LE, Pollycove M. Biologic responses of low doses of ionizing radiation: detriment versus hormesis. Part 1. Dose responses of cells and tissues. J Nucl Med 42:17N-27N; 2001.
9. Flynn JMD. Commentary on hormesis and public risk communication: is there a basis for public discussions? Hum Exp Toxicol 22:31-34; 2003.
10. Howard BN. How to defuse one of the terrorists' chief weapons. Abstracts of papers presented at the 36th Midyear Topical Meeting of the Health Physics Society, San Antonio, TX, 26-29 January 2003. McLean, VA: Health Physics Society; 2003:S29.
11. Jonas WB. The future of hormesis: what is the clinical relevance to hormesis? Crit Rev Toxicol 31:655-658; 2001.
12. Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Statistical Assoc 53:457-482; 1958.
13. Kitchin KT. Defining, explaining and understanding hormesis. Hum Exp Toxicol. 21:105-106; 2002.
14. Lloyd RD. More about mammary tumors in beagles given radium-226. Radiat Res 139:248-253; 1994.
15. Lloyd RD, Miller SC, Taylor GN, Bruenger FW, Jee WSS, Angus W. Relative effectiveness of 239Pu and other internal emitters for bone cancer induction in beagles. Health Phys 67:346-353; 1994a.
16. Lloyd RD, Taylor GN, Angus W, Bruenger FW, Miller SC. Soft tissue tumors among beagles injected with 226Ra. Health Phys 66:283-292; 1994b.
17. Lloyd RD, Taylor GN, Angus W, Miller SC. Soft tissue tumors in beagles injected with 241Am citrate. Health Phys 68:225-233; 1995a.
18. Lloyd RD, Angus W, Taylor GN, Bruenger FW, Miller SC. Soft tissue tumors induced by monomeric 239Pu. Health Phys 69:530-537; 1995b.
19. Lloyd RD, Angus W, Taylor GN, Miller SC. Soft tissue tumors among beagles injected with 90Sr, 228Ra or 228Th. Health Phys 69:272-277; 1995c.
20. Mays CW, Lloyd RD, Taylor GN, Wrenn ME. Cancer incidence and lifespan vs. alpha particle dose in beagles. Health Phys 52:617-624; 1987.
21. Mossman KL. Deconstructing radiation hormesis. Health Phys 80:263-269; 2001.
22. Parsons PA. Radiation hormesis: an ecological and energetic perspective. Med Hypotheses 57:277-279; 2001.
23. Parsons PA. Radiation hormesis: challenging LNT theory via ecological and evolutionary considerations. Health Phys 82:513-516; 2002.
24. Pollycove M, Feinendegen LE. Biologic responses to low doses of ionizing radiation: deteriment versus hormesis. Part 2. Dose responses of organisms. J Nucl Med 42:26N-32N; 2001.
25. Precages JL. Radiation hormesis, or could all that radiation be good for us? J Nucl Med Technol 31:11-17; 2003.
26. Siegel S. Nonparametric statistics for the behavioral sciences. New York: McGraw-Hill Book Co.; 1956.
27. Stover BJ. Life shortening consequent to internal irradiation from 239Pu. Health Phys 22:823-827; 1972.
28. Stover BJ, Atherton DA, Buster DS. Protracted hepatic, splenic and renal retention of Pu in the beagle. Health Phys 20:369-374; 1971.
29. Taylor GN, Lloyd RD, Mays CW, Angus W, Miller SC, Shabestari L, Hahn FF. Plutonium- or americium-induced liver tumors and lesions in beagles. Health Phys 61:337-347; 1991.
30. Taylor GN, Lloyd RD, Bruenger FW, Miller SC. 241Am-induced thyroid lesions in the beagle. Health Phys 64:653-660; 1993.
31. Tong J, Qin L, Geng M. Dose-related effect of irradiation on circadian rhythm of cellular messengers in neural and immune system of mouse. Chin Med J (English) 112:146-148; 1999.
32. Van Voorhies WA. Hormesis and aging. Hum Exp Toxicol 20:315-317; 2001.
33. Woolf CM. Principles of biometry. Princeton, NJ: D. VanNostrand Co., Inc.; 1968.