Characterization of the Performance of Bin Blenders: Part 1 of 3: Methodology

Pharmaceutical Technology

Volumn 28, Issue 5, 2004, Pages 70-86

  Alexander, Albert ^a   Arratia, Paulo ^b   Goodridge, Chris ^a   Sudah, Osama ^d   Brone, Dean ^c   Muzzio, Fernando ^a  

^a The State University of New Jersey   (United States)

^b HAVERFORD COLLEGE   (United States)

^c PFIZER INC   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MIXING; PARAMETER ESTIMATION;

COHESION; COHESIVE MIXTURES; FREE-FLOWING; MIXING MECHANISMS;

DRUG PRODUCTS;

ADHESION; ARTICLE; BIN BLENDER; DRUG MANUFACTURE; FLOW KINETICS; FLOW RATE; PARAMETER; POWDER; PRACTICE GUIDELINE; PROCESS MODEL; PROCESS TECHNOLOGY; STATISTICAL ANALYSIS; VELOCITY;

EID: 2442629246     PISSN: 15432521     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. J. Adams and A. Baker, "An Assessment of Dry Blending Equipment," Transactions of the Institution of Chemical Engineers 34, 91-107 (1956).
2. J.T. Carstensen and M.R. Patel, "Blending of Irregularly Shaped Particles," Powder Technol. 17, 273-282 (1977).
3. N. Harnby, "A Comparison of the Performance of Industrial Solids Mixers Using Segregating Materials," Powder Technol. 1, 94-102 (1967).
4. Z.T. Chowhan and E.E. Linn, "Mixing of Pharmaceutical Solids I: Effect of Particle Size on Mixing in Cylindrical Shear and V-Shaped Tumbling Mixers," Powder Technol. 24, 237-244 (1979).
5. A. Kaufman, "Mixing of Solids," Ind. Eng. Chem. Fund. 1, 104-106 (1962).
6. J.C. Samyn and K.S. Murthy, "Experiments in Powder Blending and Unblending," J. Pharm. Sci. 63 (3), 370-373 (1974).
7. D. Brone, A. Alexander, and F.J. Muzzio, "Quantitative Characterization of Mixing of Dry Powders in V-Blenders," AIChE Journal 44 (2), 271-278 (1998).
8. D. Brone and F. Muzzio, "Enhanced Mixing in Double-Cone Blenders," Powder Technol. 110 (3), 179-189 (2000).
9. D.S. Cahn, T.W. Healy, and D.W. Fuerstenau, "Blending Geometry in the Mixing of Solids," Ind. Eng. Chem. PD&D 4, 318-322 (1965).
10. S.S. Wiedenbaum, "Mixing of Solids in a Twin Shell Blender," Ceramic Age (August), 39-43 (1963).
11. O. Sudah, D. Coffin-Beach, and F.J. Muzzio, "Quantitative Characterization of Mixing of Free-Flowing Granular Materials in Tote (Bin)-Blenders," Powder Technol. 126 (2), 191-200 (2002).
12. O. Sudah, D. Coffin-Beach, and F.J. Muzzio, "Effects of Blender Rotational Speed and Discharge on the Homogeneity of Cohesive and Free-Flowing Mixtures," Int J. Pharma. 247 (1,2), 57-68 (2002).
13. O. Sudah et al., "Mixing of Cohesive Pharmaceutical Formulations in Tote (Bin) Blenders," Drug Dev. Ind. Pharm. 28 (8), 905-918 (2002).
14. K.W. Carley-Macauly and M.B. Donald, "The Mixing of Solids in Tumbling Mixers-I," Chem. Eng. Sci. 17, 493-506 (1962).
15. K.W. Carley-Macauly and M.B. Donald, "The Mixing of Solids in Tumbling Mixers-II," Chem. Eng. Sci. 19, 191-199 (1964).
16. A. Alexander, T. Shinbrot, and F.J. Muzzio, "Granular Segregation in the Double-Cone Blender: Transitions and Mechanisms," Phys. Fluids 13 (3), 578-587 (2001).
17. K.J. Sethuraman and G.S. Davies, "Studies on Solids Mixing in a Double-Gone Blender," Powder Technol. 5, 115-118 (1971).
18. F.J. Muzzio, et al., "Sampling Practices in Powder Blending," Int. J. Pharm. 155, 153-178 (1997).
19. F.J. Muzzio et al., "Sampling and Characterization of Pharmaceutical Powder and Granular Blends," Int. J. Pharma. 250 (1), 51-64 (2003).
20. F.J. Muzzio et al., "An Improved Powder Sampling Tool," Pharm. Technol. 23 (4), 92-110 (1999).
21. A. Alexander, T. Shinbrot, and F.J. Muzzio, "Segregation Patterns in V-Blenders," Chemical Engineering Science 58, 487-96 (2003).
22. G. Boehm et al., "The Use of Stratefied Sampling of Blend and Dosage Units to Demonstrate Adequacy of Mix for Powder Blends," PDA J. Pharm. Sci. Tech. 57 (2), 64-74 (2003).
23. T. Shinbrot, A. Alexander, and F. Muzzio, "Spontaneous Chaotic Granular Mixing," Nature 397, 675-678 (1999).
24. R. Hogg et al., "Diffusional Mixing in an Ideal System," Chem. Eng. Sci. 21, 1025-1038 (1966).
25. H. Henein, J.K. Brimacombe, and A.P. Watkinson, "Experimental Study of Transverse Bed Motion in Rotary Kilns," Metall. Trans. 14B, 191-205 (1983).
26. O.R. Walton, "Particle-Dynamics Calculation of Shear Flow," in Mechanics of Granular Materials: New Models and Constitutive Relations, J.T. Jenkins and M. Satake, Eds. (Elsevier Science, Amsterdam, 1983), pp. 327-338.
27. O.R. Walton and R.L. Braun, "Stress Calculations for Assemblies of Inelastic Spheres in Uniform Shear, "Acta Mech. 63, pp. 73-86 (1986).
28. S. Luding, et al., "Onset of Convection in Molecular Dynamics Simulations of Grains," Physical Review E 50 (3), R1762-R1765 (1994).
29. M. Moakher, T. Shinbrot, and F.J. Muzzio, "Experimentally Validated Computations of Flow, Mixing and Segregation of NonCohesive Grains in 3D Tumbling Blenders," Powder Technol. 109, 58-71 (2000).
30. P.W. Cleary and J.J. Monaghan, "Conduction Modelling Using Smoothed Particle Hydrodynamics," J. Comput. Physics, 148 (1) 227-264 (1999).
31. P.W. Cleary and M.L. Sawley, "DEM Modelling of Industrial Granular Flows: 3D Case Studies and the Effect of Particle Shape on Hopper Discharge," Appl. Mathe. Modell. 26 (2), 89-111 (2002).
32. R. Pfeffer et al., "Synthesis of Engineered Particulates with Tailored Properties Using Dry Particle Coating," Powder Technol. 117 (1-2), 40-67 (2001).
33. O. Sudah et al., "Simulation and Experiments of Mixing and Segregation in a Tote-Blender," AIChE Journal (currently in press).