Polymorphisms of the porcine androgen receptor gene affecting its amino acid sequence and expression level

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1678, Issue 2-3, 2004, Pages 94-101

  Trakooljul, Nares ^a   Ponsuksili, Siriluck ^a   Schellander, Karl ^a   Wimmers, Klaus ^a,b  

^a UNIVERSITY OF BONN   (Germany)

^b LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

Author keywords

Androgen receptor; Candidate gene; Expression; Promoter; SNP

Indexed keywords

ANDROGEN RECEPTOR; MESSENGER RNA; PURINE; PYRIMIDINE;

ADRENAL GLAND; ALLELE; AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; EXON; FEMALE; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENE ISOLATION; GENE LOCATION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC TRAIT; GENETIC TRANSCRIPTION; HAPLOTYPE; HEMIZYGOSITY; HORMONE RESPONSIVE ELEMENT; HUMAN; HYPOPHYSIS; JEJUNUM; LEUKOCYTE; LIVER; MALE; MAMMARY GLAND; MICROSATELLITE MARKER; MUSCLE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR GENE; REPRODUCTION; RNA TRANSLATION; SEGREGATION ANALYSIS; SWINE; TONSIL; UTERUS;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; EXONS; FEMALE; GENE EXPRESSION REGULATION; HAPLOTYPES; HUMANS; MALE; MICE; MICROSATELLITE REPEATS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PEDIGREE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, ANDROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; SWINE; TISSUE DISTRIBUTION;

INSERTION SEQUENCES; SUIDAE; SUS SCROFA;

EID: 2442608713     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbaexp.2004.02.004     Document Type: Article

References (38)

1. Adler A.J., Danielsen M., Robins D.M. Androgen-specific gene activation via a consensus glucocorticoid response element is determined by interaction with nonreceptor factors. Proc. Natl. Acad. Sci. 89:1992;11660-11663
2. Bentvelsen F.M., McPhaul M.J., Wilson C.M., Wilson J.D., George F.W. Regulation of immunoreactive androgen receptor in the adrenal gland of the adult rat. Endocrinology. 137:1996;2639-2659
3. Brinkmann A.O., Blok L.J., de Ruiter P.E., Doesburg P., Steketee K., Berrevoets C.A., Trapman J. Mechanisms of androgen receptor activation and function. J. Steroid Biochem. Mol. Biol. 69:1999;307-313
4. Chen S., Supakar P.C., Vellanoweth R.L., Song C.S., Chatterjee B., Roy A.K. Functional role of a conformationally flexible homopurine/homopyrimidine domain of the androgen receptor gene promoter interacting with Sp1 and a pyrimidine single strand DNA-binding protein. Mol. Endocrinol. 11:1997;3-15
5. Choong C.S., Kemppainen J.A., Wilson E.M. Evolution of the primate androgen receptor: a structural basis for disease. J. Mol. Evol. 47:1998;334-342
6. Choong C.S., Kemppainen J.A., Zhou Z.X., Wilson E.M. Reduced androgen receptor gene expression with first exon CAG repeat expansion. Mol. Endocrinol. 10:1996;1527-1535
7. Cleutjens K.B., van Eekelen C.C., van der Korput H.A., Brinkmann A.O., Trapman J. Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter. J. Biol. Chem. 271:1996;6379-6388
8. Gottlieb B., Beitel L.K., Lumbroso R., Pinsky L., Trifiro M. Update of the androgen receptor gene mutations database. Human Mutat. 14:1999;103-114
9. Grad J.M., Dai J.L., Wu S., Burnstein K.L. Multiple androgen response elements and a Myc consensus site in the androgen receptor (AR) coding region are involved in androgen-mediated up-regulation of AR messenger RNA. Mol. Endocrinol. 13:1999;1896-1911
10. Grossmann M.E., Lindzey J., Kumar M.V., Tindall D.J. The mouse androgen receptor is suppressed by the 5′-untranslated region of the gene. Mol. Endocrinol. 8:1994;448-455
11. Harlizius B., Rattink A.P., de Koning D.J., Faivre M., Joosten R.G., van Arendonk J.A., Groenen M.A. The X chromosome harbors quantitative trait loci for backfat thickness and intramuscular fat content in pigs. Mamm. Genome. 11:2000;800-802
12. He B., Kemppainen J.A., Voegel J.J., Gronemeyer H., Wilson E.M. Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH(2)-terminal domain. J. Biol. Chem. 274:1999;37219-37225
13. Horwitz K.B., Jackson T.A., Bain D.L., Richer J.K., Takimoto G.S., Tung L. Nuclear receptor coactivators and corepressors. Mol. Endocrinol. 10:1996;1167-1177
14. Jenster G., van der Korput H.A., Trapman J., Brinkmann A.O. Identification of two transcription activation units in the N-terminal domain of the human androgen receptor. J. Biol. Chem. 270:1995;7341-7346
15. Jenster G., van der Korput A., Trapman J., Brinkmann A.O. Functional domains of the human androgen receptor. J. Steroid Biochem. Mol. Biol. 41:1992;671-675
16. Knott S.A., Marklund L., Haley C.S., Andersson K., Davies W., Ellegren H., Fredholm M., Hansson I., Hoyheim B., Lundstrom K., Moller M., Andersson L. Multiple marker mapping of quantitative trait loci in a cross between outbred wild boar and large white pigs. Genetics. 149:1998;1069-1080
17. Lu S., Liu M., Epner D.E., Tsai S.Y., Tsai M.J. Androgen regulation of the cyclin-dependent kinase inhibitor p21 gene through an androgen response element in the proximal promoter. Mol. Endocrinol. 13:1999;376-384
18. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P. The nuclear receptor superfamily: the second decade. Cell. 83:1995;835-839
19. Michel D., Chatelain G., Herault Y., Brun G. The long repetitive polypurine/polypyrimidine sequence (TTCCC)48 forms DNA triplex with PU-PU-PY base triplets in vivo. Nucleic Acids Res. 20:1992;439-443
20. Mizokami A., Chang C. Induction of translation by the 5′-untranslated region of human androgen receptor mRNA. J. Biol. Chem. 269:1994;25655-25659
21. Nelson C.C., Hendy S.C., Shukin R.J., Cheng H., Bruchovsky N., Koop B.F., Rennie P.S. Determinants of DNA sequence specificity of the androgen, progesterone, and glucocorticoid receptors: evidence for differential steroid receptor response elements. Mol. Endocrinol. 13:1999;2090-2107
22. Pelletier G. Localization of androgen and estrogen receptors in rat and primate tissues. Histol. Histopathol. 15:2000;1261-1270
23. Quigley C.A., De Bellis A., Marschke K.B., el-Awady M.K., Wilson E.M., French F.S. Androgen receptor defects: historical, clinical, and molecular perspectives. Endocr. Rev. 16:1995;271-321
24. Reid J., Murray I., Watt K., Betney R., McEwan I.J. The androgen receptor interacts with multiple regions of the large subunit of general transcription factor TFIIF. J. Biol. Chem. 277:2002;41247-41253
25. Roche P.J., Hoare S.A., Parker M.G. A consensus DNA-binding site for the androgen receptor. Mol. Endocrinol. 6:1992;2229-2235
26. Rohrer G.A. Identification of quantitative trait loci affecting birth characters and accumulation of backfat and weight in a Meishan-White Composite resource population. J. Anim. Sci. 78:2000;2547-2553
27. Rohrer G.A., Keele J.W. Identification of quantitative trait loci affecting carcass composition in swine: II. Muscling and wholesale product yield traits. J. Anim. Sci. 76:1998;2255-2262
28. Rosenfeld M.G., Glass C.K. Coregulator codes of transcriptional regulation by nuclear receptors. J. Biol. Chem. 276:2001;36865-36868
29. Seifert J.N., Larsen N.J., Marklund S., Hu Z.L., Rohrer G.A., Rothschild M.F. Genetic linkage and physical mapping of the porcine androgen receptor (AR) gene. J. Anim. Sci. 77:1999;785-786
30. Simpson D.A., Feeney S., Boyle C., Stitt A.W. Retinal VEGF mRNA measured by SYBR green I fluorescence: a versatile approach to quantitative PCR. Mol. Vis. 6:2000;178-183
31. Singh R., Artaza J.N., Taylor W.E., Gonzalez-Cadavid N.F., Bhasin S. Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology. 144:2003;5081-5088
32. Slomczynska M., Duda M., Sl zak K. The expression of androgen receptor, cytochrome P450 aromatase and FSH receptor mRNA in the porcine ovary. Folia Histochem. Cytobiol. 39:2001;9-13
33. Tilley W.D., Marcelli M., McPhaul M.J. Expression of the human androgen receptor gene utilizes a common promoter in diverse human tissues and cell lines. J. Biol. Chem. 265:1990;13776-13781
34. Takane K.K., McPhaul M.J. Functional analysis of the human androgen receptor promoter. Mol. Cell. Endocrinol. 119:1996;83-93
35. Trakooljul N., Ponsuksili S., Schellander K., Wimmers K. A highly polymorphic repetitive polypyrimidine/polypurine (CCTTT)n sequence in the 5′ untranslated sequence of the porcine androgen receptor gene. Anim. Genet. 31:2000;288-289
36. Tripepi S., Carelli A., Perrotta E., Brunelli E., Tavolaro R., Facciolo R.M., Canonaco M. Morphological and functional variations of Leydig cells in testis of the domestic pig during the different biological stages of development. J. Exp. Zool. 287:2000;167-175
37. Warpeha K.M., Xu W., Liu L., Charles I.G., Patterson C.C., Ah-Fat F., Harding S., Hart P.M., Chakravarthy U., Hughes A.E. Genotyping and functional analysis of a polymorphic (CCTTT)n repeat of NOS2A in diabetic retinopathy. FASEB J. 13:1999;1825-1832
38. Wiren K.M., Zhang X., Chang C., Keenan E., Orwoll E.S. Transcriptional up-regulation of the human androgen receptor by androgen in bone cells. Endocrinology. 138:1997;2291-2300