Epstein-Barr Virus-Associated Composite Lymphoma Composed of Peripheral T-Cell Lymphoma and an Anaplastic Variant of a Diffuse Large B-Cell Type of Non-Hodgkin's Lymphoma and Strongly Expressing p53 Protein

International Journal of Hematology

Volumn 79, Issue 3, 2004, Pages 260-265

  Hirose, Yuko ^a   Fukushima, Toshihiro ^a   Masaki, Yasufumi ^a   Shimoyama, Kumiko ^a   Karasawa, Hiromi ^a   Ogawa, Noriyoshi ^a   Wano, Yuji ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Anaplastic variant of diffuse large B cell lymphoma; Composite lymphoma; Epstein Barr virus; p53 protein; Peripheral T cell lymphoma

Indexed keywords

CD15 ANTIGEN; CD20 ANTIBODY; CD3 ANTIGEN; CD30 ANTIGEN; CD45 ANTIGEN; CD79 ANTIGEN; CD79A ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; PROTEIN P53; UNCLASSIFIED DRUG;

AGED; ANAPLASTIC CARCINOMA; ARTICLE; B CELL LYMPHOMA; CANCER DIAGNOSIS; CARCINOGENESIS; CASE REPORT; CELL CYCLE; CELL IMMORTALIZATION; CELL TYPE; CERVICAL LYMPH NODE; COMPOSITE LYMPHOMA; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; EPSTEIN BARR VIRUS; FEMALE; FEVER; HUMAN; IMMUNOBLASTIC LYMPHOMA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPH NODE BIOPSY; LYMPHADENOPATHY; NONHODGKIN LYMPHOMA; PHENOTYPE; PROTEIN EXPRESSION; T CELL LYMPHOMA; T LYMPHOCYTE SUBPOPULATION; TRANSCRIPTION INITIATION; VIRUS INFECTION;

EID: 2442601547     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.03156     Document Type: Article

References (31)

1. Kim H, Hendrickson MR, Dorfman RF. Composite lymphoma. Cancer. 1977;40:959-976.
2. Kim H. Composite lymphoma and related disorders. Am J Clin Pathol. 1993;99:445-451.
3. Gonzalez CL, Meroides LJ, Jaffe ES. Composite lymphoma: a clinicopathologic analysis of nine patients with Hodgkin's disease and non-Hodgkin's lymphoma. Am J Clin Pathol. 1991;96:81-89.
4. Tobinai K, Ohtsu T, Hayashi M, et al. Epstein-Barr virus (EBV) genome carrying monoclonal B-cell lymphoma in a patient with adult T-cell leukemia-lymphoma. Leuk Res. 1991;15:837-846.
5. Strickler JG, Amsden TW, Kurtin PJ. Small B-cell lymphoid neoplasms with coexisting T-cell lymphomas. Am J Clin Pathol. 1992;98:424-429.
6. Liu YC, Tomashefski JF Jr, Cleveland RP, et al. Composite cutaneous T-cell lymphoma and small B-cell lymphocytic lymphoma: morphologic, and molecular genetic documentation of concurrent lymph node involvement. Mod Pathol. 1994;7:641-646.
7. Zettl A, Lee SS, Rudiger T, et al. Epstein-Barr virus associated B-cell lymphoproliferative disorders in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified. Am J Clin Pathol. 2002;117:368-379.
8. Delsol G, Ralfkiaer E, Stein H, Wright D, Jaffe ES. Anaplastic large cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. WHO Classification: Tumors of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001:230-235.
9. Borisch B, Finke J, Hennig I, et al. Distribution and localization of Epstein-Barr virus subtypes A and B in AIDS-related lymphomas and lymphatic tissue of HIV-positive patients. J Pathol. 1992;168:229-236.
10. Hamilton-Dutroit SJ, Raphael M, Audouin J, et al. In situ demonstration of Epstein-Barr virus small RNAs (EBER) in acquired immunodeficiency syndrome-related lymphomas: correlation with tumor morphology and primary site. Blood. 1993;82:619-624.
11. Hanto DW, Frizzera G, Purtilo DT, et al. Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus. Cancer Res. 1981;41:4253-4261.
12. Penn I. Malignant lymphomas in organ transplant recipients. Transplant Proc. 1981;13:736-738.
13. Kamel OW, van de Riin M, Weiss LM, et al. Brief report: reversible lymphoma associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis. N Engl J Med. 1993;328:1317-1321.
14. Dawson TM, Starkebaum G, Wood BL, Wilkins RF, Gown AM. Epstein-Barr virus, methotrexate, and lymphoma in patients with rheumatoid arthritis and primary Sjögren's syndrome: case series. J Rheumatol. 2001;28:47-53.
15. Hirose Y, Masaki Y, Okada J, et al. Epstein-Barr virus associated B-cell type non-Hodgkin's lymphoma with concurrent p53 protein expression in a rheumatoid arthritis patient treated with methotrexate. Int J Hematol. 2002;75:412-415.
16. Anagnostopoulos I, Herbst H, Niedobitek G, Stein H. Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization. Blood. 1989;74:810-816.
17. Herbst H, Dallenbach F, Hummel M, et al. Epstein-Barr virus DNA and latent gene products in Ki-1 (CD30)-positive anaplastic large cell lymphomas. Blood. 1991;78:2666-2673.
18. Shimakage M, Nakamine H, Tamura S, Takenaka T, Yutsudo M, Hakura H. Detection of Epstein-Barr virus transcript in anaplastic large-cell lymphomas by mRNA in situ hybridization. Hum Pathol. 1997;28:1415-1419.
19. Hirose Y, Masaki Y, Shimoyama K, et al. Epstein-Barr virus-associated anaplastic large cell variant of diffuse large B-cell-type non-Hodgkin's lymphoma with concurrent p53 protein expression. Int J Hematol. 2003;77:499-502.
20. Szekely W, Selivanova G, Magnusson KP, et al. EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins. Proc Natl Acad Sci U S A. 1993;90:5455-5459.
21. Chen W, Cooper NR. Epstein-Barr virus nuclear antigen 2 and latent membrane protein independently transactivate p53 through induction of NF-κB activity. J Virol. 1996;70:4849-4853.
22. Shibata D, Weiss LM, Nathwani BN, et al. Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma. Blood. 1991;77:1527-1533.
23. Hirose Y, Masaki Y, Shimizu S, et al. Association of Epstein-Barr virus with human immunodeficiency virus-negative T cell lymphomas in Japan, in situ hybridization, polymerase chain reaction and immunohistochemical studies. Leukemia. 1996;10:1673-1675.
24. Khan G, Norton AJ, Slavin G. Epstein-Barr virus in angioimmunoblastic T-cell lymphomas. Histopathology. 1993;22:145-149.
25. Menke DM, Griesser H, Moder KG, et al. Lymphomas in patients with connective tissue disease: comparison of p53 protein expression and latent EBV infection in patients immunosuppressed and not immunosuppressed with methotrexate. Am J Clin Pathol. 2000;113:212-218.
26. Bartek J, Bartkova J, Vojtesek B, et al. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene. 1991;6:1699-1703.
27. Edwards RH, Raab-Traub N. Alterations of p53 gene in Epstein-Barr virus-associated immunodeficiency-related lymphomas. J Virol. 1994;68:1309-1315.
28. Cesarman E, Inghirami G, Chadburn A, et al. High levels of p53 protein expression do not correlate with p53 gene mutations in anaplastic large cell lymphoma. Am J Pathol. 1993;143:845-856.
29. Szekely L, Selivanova G, Magnusson KP, et al. EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins. Proc Natl Acad Sci U S A. 1993;90:5459-5459.
30. Chen W, Cooper NR. Epstein-Barr virus nuclear antigen-2 and latent membrane protein independently transactivate p53 through induction of NF-κB activity. J Virol. 1996;70:4849-4853.
31. Oyama T, Ichimura K, Suzuki R, et al. Senile EBV+ B-cell lymphoproliferative disorders: a clinicopathologic study of 22 patients. Am J Surg Pathol. 2003;27:16-26.