How to improve the bioavailability of poorly soluble drugs

American Pharmaceutical Review

Volumn 7, Issue 2, 2004, Pages 80-85+93

  Garad, Sudhakar D ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLGLYCEROL; ATROPINE; CESAMET POVIDONE; CETIRIZINE; CHLORAMPHENICOL; CLINDAMYCIN; CLINDAMYCIN PHOSPHATE; CODEINE PHOSPHATE; CODEINE SULFATE; CYCLODEXTRIN; ESTER; METRONIDAZOLE; N,N DIMETYLGLYCINATE; NABILONE; NEW DRUG; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYTOIN; PRODRUG; PSEUDOEPHEDRINE; SUCCINIC ACID; SULFATHIAZOLE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; COOLING; DISPERSION; DRUG BIOAVAILABILITY; DRUG CLASSIFICATION; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG MEGADOSE; DRUG SOLUBILITY; DRUG SYNTHESIS; HEATING; HUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PHYSICAL PHASE; SPRAY DRYING; STOMACH DISEASE; TOXICOLOGY;

EID: 2442593013     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Bundgaard and Johansen. "Pro-drugs as Drug Delivery System." Int. J. Pharm. 7, (1980), 129-136.
2. Philip L. Gould. "Salt Selection for Basic Drugs." Int. J. Pharm.", 33 (1986), 201-217.
3. Sekiguchi and Obi. "Studies on Absorption of Eutectic Mixture." Chem. Pharm. Bull., 9, (1961), 866-872.
4. Chiou and Rigelman. "Pharmaceutical Application of Solid Dispersion System." J. Pharm. Sci., 60, (1971),1281-1302.
5. Serajuddin Abu. "Solid Dispersion of Poorly Water Soluble Drugs: Early Promises, Subsequent Problems and Recent Breakthroughs." 10(1999), 1058-66.
6. Rankell, Liberman and Schiffmann. "Drying" in the Theory and Practices of Industrial Pharmacy. 3rd edition, edited by L. Lachmanb, H.A. Liberman and J.L. Kanig, Lea and Fabiger, Philadelphia, pp 66-68, 1986.
7. Breitenbach Jorg. "Hot Melt Extrusion: From Process to Drug Delivery Technology." Euro. J. of Pharm and biopharma, 54, (2002), 107-117.
8. "Understanding Amorphous Solids." A short course at AAPS, Toronto 2002.