Sputum carcinoembryonic antigen, neuron-specific enolase and cytokeratin fragment 19 levels in lung cancer diagnosis

Respirology

Volumn 9, Issue 1, 2004, Pages 54-59

  Kalomenidis, Ioannis ^a   Dimakou, Katerina ^b   Kolintza, Androniki ^a   Vlami, Katerina ^a   Papadakis, Manos ^b   Sotiropoulou, Cristina ^a   Orphanidou, Dora ^b   Roussos, Charis ^a   Papiris, Spyros ^a  

^a EVANGELISMOS HOSPITAL   (Greece)

^b SOTIRIA GENERAL HOSPITAL   (Greece)

Author keywords

Carcinoembryonic antigen; Cytokeratin fragment 19; Lung cancer; Neuron specific enolase; Sputum tumour markers

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 19; NEURON SPECIFIC ENOLASE; TUMOR MARKER;

ADULT; AGED; ANTIGEN DETECTION; ARTICLE; BRONCHIECTASIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; PNEUMONIA; PRIORITY JOURNAL; ROC CURVE; SPUTUM ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; CARCINOEMBRYONIC ANTIGEN; CARCINOMA, BRONCHOGENIC; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; IMMUNORADIOMETRIC ASSAY; KERATINS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PHOSPHOPYRUVATE HYDRATASE; ROC CURVE; SENSITIVITY AND SPECIFICITY; SPECIMEN HANDLING; SPUTUM;

EID: 2442585316     PISSN: 13237799     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2003.00536.x     Document Type: Article

References (23)

1. Ferrigno D, Buccheri G, Biggi A. Serum tumour markers in lung cancer: history, biology and clinical applications. Eur. Respir. J. 1994; 7: 186-97.
2. Bates J, Rutherford R, Divilly M et al. Clinical value of CYFRA 21-1, carcinoembryonic antigen, neurone-specific enolase, tissue polypeptide specific antigen and tissue polypeptide antigen in the diagnosis of lung cancer. Eur. Respir. J. 1997; 10: 2535-8.
3. Pastor A, Menendez R, Cremades MJ, Pastor V, Llopis R, Aznar J. Diagnostic value of SCC, CEA and CYFRA 21-1 in lung cancer: a Bayesian analysis. Eur. Respir. J. 1997; 10: 603-9.
4. Athanassiadou P, Psyhoyou H, Kyrkou K, Athanassiades P, Moulopoulos S. Expression of keratins and carcinoembryonic antigen in bronchial squamous metaplasia and lung carcinomas. Acta Cytol. 1995; 39: 1161-6.
5. Ohwada A, Takahashi H, Nagaoka I, Iwabuchi K, Mikami O, Kira S. Effect of cigarette smoke on the mRNA and protein expression of carcinoembryonic antigen (CEA), a possible chemoattractant for neutrophils in human bronchioloalveolar tissues. Thorax 1995; 50: 651-7.
6. Quillien v, Ramee MP, Bansard JY et al. Serum and tissue distribution of a fragment of cytokeratin 19 (cyfra 21-1) in lung cancer patients. Anticancer Res. 1995; 15: 2857-63.
7. Sanguinetti CM, Riccioni G, Marchesani F, Pela R, Cecarini L. Bronchoalveolar lavage fluid level of carcinoembryonic antigen in the diagnosis of peripheral lung cancer. Monaldi Arch. Chest Dis. 1995; 50: 177-82.
8. Wesselius LJ, Dark DS, Papasian CJ. Airway carcinoembryonic antigen concentrations in patients with central lung cancer or chronic bronchitis. Chest 1990; 98: 393-7.
9. Cremades MJ, Menendez R, Pastor A, Llopis R, Aznar J. Diagnostic value of cytokeratin fragment 19 (CYFRA 21-1) in bronchoalveolar lavage fluid in lung cancer. Respir. Med. 1998; 92: 766-71.
10. Trevisani L, Putinati S, Sartori S, Abbasciano V, Bagni B. Cytokeratin tumor marker levels in bronchial washing in the diagnosis of lung cancer. Chest 1996; 109: 104-8.
11. Stockley RA. Measurement of soluble proteins in lung secretions. Thorax 1984; 39: 241-7.
12. Kennedy TC, Proudfoot SP, Piantadosi S et al. Efficacy of two sputum collection techniques in patients with air flow obstruction. Acta Cytol. 1999; 43: 630-6.
13. Stockley RA, Shaw J, Whitfield AG, Whitehead TP, Clarke CA, Burnett D. Effect of cigarette smoking, pulmonary inflammation and lung disease on concentrations of carcinoembryonic antigen in serum and secretions. Thorax 1986; 41: 17-24.
14. Pin I, Gibson PG, Kolendowicz R et al. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992; 47: 25-9.
15. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976; 72: 248-54.
16. Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 1983; 148: 839-43.
17. Armitage P, Berry G. Bayes' theorem. In: Armitage P, Berry G (eds). Statistical Methods in Medical Research, 3rd edn. Blackwell Science, London, 1994; 71-7.
18. Griner PF, Mayewski RJ, Mushlin AI, Greenland P. Selection and interpretation of diagnostic tests and procedures: principles and applications. Ann. Intern. Med. 1981; 94: 557-92.
19. de Diego A, Compte L, Sanchis J, Enguidanos MJ, Marco J. Usefulness of carcinoembryonic antigen determination in bronchoalveolar lavage fluid. A comparative study among patients with peripheral lung cancer, pneumonia and healthy individuals. Chest 1991; 100: 1060-3.
20. Goldstein N, Lippmann ML, Goldberg SK, Fein AM, Shapiro B, Leon SA. Usefulness of tumor markers in serum and bronchoalveolar lavage of patients undergoing fiberoptic bronchoscopy. Am. Rev. Respir. Dis. 1985; 132: 60-4.
21. Merrill WW, Goodman M, Matthay RA et al. Quantitation of carcinoembryonic antigen in the lung lining fluid of normal smokers and nonsmokers. Am. Rev. Respir. Dis. 1981; 123: 29-31.
22. Dobashi N, Fujita J, Ohtsuki Y et al. Elevated serum and BAL cytokeratin 19 fragment in pulmonary fibrosis and acute interstitial pneumonia. Eur. Respir. J. 1999; 14: 574-8.
23. Kanazawa H, Yoshikawa T, Yamada M et al. CYFRA 21-1, a cytokeratin subunit 19 fragment, in bronchoalveolar lavage fluid from patients with interstitial lung disease. Clin. Sci. 1998; 94: 531-5.