The Structure and Mechanical Properties of the Mitral Valve Leaflet-Strut Chordae Transition Zone

Journal of Biomechanical Engineering

Volumn 126, Issue 2, 2004, Pages 244-251

  Chen, Ling ^a   Yin, Frank C P ^b   May Newman, Karen ^a  

^a UTC Aerospace Systems   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COMPUTER SIMULATION; HISTOLOGY; MATHEMATICAL MODELS; STRESS CONCENTRATION;

BIAXIAL TESTING; BIOMECHANICAL VALVE MODELS;

BIOMECHANICS;

COLLAGEN FIBER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CHORDA TENDINEA; CHORDA TENDINEA RUPTURE; GEOMETRY; HISTOLOGY; MATHEMATICAL MODEL; MECHANICAL STRESS; MITRAL VALVE; MITRAL VALVE LEAFLET STRUT CHORDAE TRANSITION ZONE; MITRAL VALVE REGURGITATION; MUSCLE STRETCHING; NONHUMAN; SWINE;

ANIMALS; ANISOTROPY; BIOMECHANICS; CHORDAE TENDINEAE; COLLAGEN; COMPUTER SIMULATION; CULTURE TECHNIQUES; ELASTICITY; MITRAL VALVE; MODELS, CARDIOVASCULAR; PROTEIN CONFORMATION; STRESS, MECHANICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

ANIMALIA; CHORDA; SUS SCROFA;

EID: 2442550799     PISSN: 01480731     EISSN: None     Source Type: Journal    
DOI: 10.1115/1.1695569     Document Type: Article

References (41)

1. Nielsen, S. L., Nygaard, H., Fontaine, A. A., Hasenkam. J. M., He, S., Andersen, N. T., and Yoganathan, A. P., 1999, Chordal force distribution determines systolic mitral leaflet configuration and severity of functional mitral regurgitation. J. Am. Coll. Cardiol., 33, pp. 843-853.
2. Salisbury, P. F., Cross, C. E., and Rieben, P. A., 1963, Chorda tendinea tension. Am. J. Physiol. (Heart), 205, pp. 385-392.
3. Cole, W. G., Chan, D., Hickey, A. J., and Wilcken, D. E., 1984, Collagen Composition of Normal and Myxomatous Human Mitral Valve., J. Biomech., 219, pp. 451-460.
4. Lim, K. O., Boughner, D. R., and Perkins, D. G., 1983, Ultrastructure and mechanical properties of chordae tendineae from a myxomatous tricuspid valve. Jpn. Heart J., 24, pp. 539-548.
5. Lam, J. H., Ranganathan, N., Wigle, E. D., and Silver, M. D., 1970, Morphology of the human mitral valve. I. Chordae tendineae: a new classification. Circulation, 41, pp. 449-458.
6. Tandler, J., 1913, Handbuch der Anatomie des Menschen. Band 3, Part 1. 84-88. Jena, Germany, Gustav Fischer.
7. May-Newman, K., and Yin, F. C., 1995, Biaxial mechanical behavior of excised porcine mitral valve leaflets. Am. J. Physiol., 269, pp. H1319-H1327.
8. Kunzelman, K. S., Cochran, R. P., Chuong, C., Ring, W. S., Verrier, E. D., and Eberhart, R. D., 1993, Finite element analysis of the mitral valve. J. Heart Valve Dis., 2, pp. 326-340.
9. Nazari, S., and Carli, F., 2000, Patterns of Systolic Stress Distribution on Mitral Valve Anterior Leaflet Chordal Apparatus. A Structural Mechanical Theoretical Analysis. J. Cardiovasc. Surg., 41(2), pp. 193-202.
10. Lomholt, M., Nielsen, S. L., Hansen, S. B., Andersen, N. T., and Hasenkam, J. M., 2002, Differential tension between secondary and primary mitral chordae in an acute in-vivo porcine model. J. Heart Valve Dis., 11(3), pp. 337-345.
11. He, S., Weston, M. W., Lemmon, J., Jensen, M., Levine, R. A., and Yoganathan, A. P., 2000, Geometric distribution of chordae tendineae: an important anatomic feature in mitral valve function. J. Heart Valve Dis., 9, pp. 495-501.
12. Krstil, R. V., 1984, Illustrated encyclopedia of human histology. 440. New York, NY, Springer-Verlag.
13. Lis, Y., Burleigh, M. C., Parker, D. J., Child, A. H., Hogg, J., and Davies, M. J., 1987, Biochemical characterization of individual normal, floppy and rheumatic human mitral valves. Biochem. J., 244, pp. 597-603.
14. Silver, M. D., 1991, Cardiovascular pathology, 2nd Ed. 85. New York, NY, Churchill Livingstone.
15. Silverman, M. E., and Hurst, J. W., 1968, The mitral complex: interaction of the anatomy, physiology and pathology of the mitral annulus, mitral valve leaflets, chordae tendineae and papillary muscles. Am. Heart J., 76(3), pp. 399-418.
16. Grande-Allen, K. J., Griffin, B. P., Ratliff, N. B., Cosgrove, D. M., and Vesely, I., 2003, Glycosaminoglycan profiles of myxomatous mitral leaflets and chordae parallel the severity of mechanical alterations. J. Am. Coll. Cardiol., 42(2), pp. 271-277.
17. Lim, K. O., and Boughner, D. R., 1977, Scanning electron microscopical study of human mitral valve chordae tendineae. Arch. Pathol. Lab Med., 101, pp. 236-238.
18. Broom, N. D., and Christie, G. W., 1982, The structure/function relationship of fresh and gluaraldehyde-fixed aortic valve leaflets. In: Caridac Bioprostheses. 476-491. New York, NY: Yourke Medical Books, Cohn LH and Gallucci V, eds.
19. Burdge, E. C., 1996, A microstructural and biomechanical analysis of the mitral valve [dissertation]. University of Washington.
20. Cochran, R. P., Kunzelman, K. S., Chuong, C. J., Sacks, M. S., and Eberhart, R. C., 1991, Nondestructive analysis of mitral valve collagen fiber orientation. ASAIO Trans., 37, pp. M447-M448.
21. Kunzelman. K. S., Sacks, M. S., Cochran, R. P., and Eberhardt, A. C., 1988, Mitral valve leaflet collagen distribution by laser analysis. Seventh Southern Biomedical Engineering Conference, 82-85.
22. Kunzelman, K. S., Cochran, R. P., Murphree, S. S., Ring, W. S., Verrier, E. D., and Eberhart, R. C., 1993, Differential collagen distribution in the mitral valve and its influence on biomechanical behavior. J. Heart Valve Dis., 2, pp. 236-244.
23. May-Newman, K., and Yin, F. C., 1998, A constitutive law for mitral valve tissue. J. Biomech. Eng., 120, pp. 38-47.
24. Downs, J., Halperin, H. R., Humphery, J., and Yin, F. C. P., 1990, An improved video-based computer tracking system for soft biomaterial testing. IEEE Trans. Biomed. Eng., 37, pp. 903-907.
25. Humphrey, J. D., Vawter, D. L., and Vito, R. P., 1987, Quantification of strains in biaxially tested soft tissues. J. Biomech., 20, pp. 59-65.
26. Humphrey, J. D., and Yin, F. C., 1989, Biomechanical experiments on excised myocardium: theoretical considerations. J. Biomech., 22, pp. 377-383.
27. Ghista, D. N., and Rao, A. P., 1973, Mitral-valve mechanics-stress-strain characteristics of excised leaflets, analysis of its functional mechanics and its medical application. Med. Biol. Eng., 11, pp. 691-702.
28. Kunzelman, K. S., and Cochran, R. P., 1992, Stress/strain characteristics of porcine mitral valve tissue: parallel versus perpendicular collagen orientation. J. Card. Surg., 7, pp. 71-78.
29. Lim, K. O., and Boughner, D. R., 1976, Morphology and relationship to extensibility curves of human mitral valve chordae tendineae. Circ. Res., 39, pp. 580-585.
30. Sacks, M. S., He, Z., Baijens, L., Wanant, S., Shan, P., Sugimoto, H., and Yoganathan, A. P., 2002, Surface strains in the anterior leaflet of the functioning mitral valve. Ann. Biomed. Eng., pp. 1281-1290.
31. Smith, A., and Brunton, J., 1977, Color atlas of histological staining techniques. Chicago, Year Book Publishers Inc.
32. May-Newman, K., 1999, Effect of left ventricular pressure on deformation in the mitral valve (Abstract). Proceedings of the First Joint BMES/EMBS Conference.
33. Karlon, W. J., McCulloch, A. D., Covell, J. W., Hunter, J. J., and Omen, J. H., 2000, Regional dysfunction correlates with myofiber disarray in transgenic mice with ventricular expression of ras. Am. J. Cardiol., 278, pp. H898-H906.
34. Millington, S., Meir, C. A., Lawrance, L., and Stolinski, C., 1998, Structure of chordae tendineae in the left ventricle of the human heart. J. Anat., 192, pp. 573-581.
35. Clark, R. E., 1973, Stress-strain characteristics of fresh and frozen human aortic and mitral leaflets and chordae tendineae. Implications for clinical use. J. Thorac. Cardiovasc. Surg., 66, pp. 202-208.
36. Lim, K. O., and Boughner, D. R., 1975, Mechanical properties of human mitral valve chordae tendineae: variation with size and strain rate. Can. J. Physiol. Pharmacol., 53, pp. 330-339.
37. Kunzelman, K. S., 1991, Engineering analysis of mitral valve structure and function [dissertation]. Dallas, TX, University of Texas-Southwestern Medical Center.
38. Chuong, C. J., Sacks, M. S., and Johnson, R. L., 1991, On the anisotropy of the canine diaphragmatic central tendon. J. Biomech., 24(7), pp. 563-576.
39. Kronick, P. L., and Sacks, M. S., 1991, Quantification of vertical-fiber defect in cattle hide by small-angle light scattering. Connect. Tissue Res., 27(1), pp. 1-13.
40. Sacks, M. S., and Chuong, C. J., 1992, Characterization of collagen fiber architecture in the canine diaphragmatic central tendon. Biomech Eng., 114(2), pp. 183-190.
41. Sacks, M. S., Smith, D. B., and Chuong, C. J., 1995, Collagen architecture of the porcine aortic valve leaflet. ASAIO 1995 Abstracts, 41(1), pp. 29.