Prevention of Hypoxic-Ischemic Encephalopathy with High-Dose, Early Phenobarbital Therapy;Prevención de la Encefalopatía Hipóxico-Isqué mica Mediante Fenobarbital en forma Temprana y a Dosis Alta

Gaceta Medica de Mexico

Volumn 140, Issue 2, 2004, Pages 147-153

  Vargas Origel, Arturo ^a,d   Espinosa García, J Oscar G ^b   Muñiz Quezada, Esmeralda ^b   Vargas Nieto, Martín Arturo ^b   Aguilar García, Gilberto ^c  

^a U de Invest en Epidemiologia Clin   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c Hospital Aranda de la Parra   (Mexico)

^d NONE   (Mexico)

Author keywords

Infant newborns; Perinatal asphyxia; Phenobarbital

Indexed keywords

PHENOBARBITAL;

ARTICLE; BIRTH WEIGHT; BLOOD PH; BRAIN DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE CLASSIFICATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; FEMALE; FISHER EXACT TEST; GESTATIONAL AGE; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INCIDENCE; INFANT; INFORMED CONSENT; MALE; NEWBORN CARE; PERINATAL ASPHYXIA; PREVENTIVE MEDICINE; RANDOMIZED CONTROLLED TRIAL; RANK SUM TEST; SIDE EFFECT; STATISTICAL ANALYSIS; STUDENT T TEST; UMBILICAL CORD BLOOD;

EID: 2442543394     PISSN: 00163813     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Vanucci RC, Perlman JM. Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics 1997;100:1004-1014.
2. Ruth V, Virkola D, Paetau R, Raivio K. Early high-dose phenobarbital treatment for prevention of hypoxic-ischemic brain damage in very low birth weight infants. J Pediatr 1988;112:81-816.
3. Hall RT, Hall FK, Daily DK. High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: a randomized, prospective study with three-year follow-up. J Pediatr 1998;132:345-348
4. Aldana VC, Romero MS, Vargas OA, Hernández AJ. Complicaciones agudas en neonatos de término con asfixia perinatal severa. Gin Obstet Mex 1995;63:123-127.
5. Van den Berg PP, Nelen WLDM, Jongsma HW, et al. Neonatal complications in newborns with an umbilical artery pH < 7.00. Am J Obstet Gynecol 1996;175: 1152-1157.
6. Hammerman C, Kaplan M. Ischemia and reperfusion injury. The ultimate pathophysiologic paradox. Clin Perinatol 1998;25:757-777.
7. Tan S, Parks DA. Preserving brain function during neonatal asphyxia. Clin Perinatol 1999;26:733-747.
8. de Haan HH, Gunn AJ, Williams CE, Heymann MA, Gluckman PD. Magnesium sulfate therapy during asphyxia in near-term fetal lambs does not compromise the fetus but does not reduce cerebral injury. Am J Obstet Gynecol 1997;176:18-27.
9. Goldberg RN, Moscoso P, Bauer CR, ety al. Use of barbiturate therapy in severe perinatal asphyxia: a randomized controlled trial. J Pediatr 1986;109:851-856.
10. Donn SM, Grasela TH, Goldstein GW. Safety of a higher loading dose of phenobarbital in the term newborn. Pediatrics 1985;75:1061-1064.
11. Saugstad OD. Role of xanthine oxidase and its inhibitor in hypoxia: reoxygenation injury. Pediatrics 1996;98:103-107.
12. Ekert P, Perlman M, Steinlin M, Hao Y. Predicting the outcome of postasphyxial hypoxic-ischemic encephalopathy within 4 hours of birth. J Pediatr 1997;131:613-617.
13. a ed. México: El Manual Moderno; 1995. p. 86.
14. Caballero S, Vázquez P, Moreno M, Gómez-Pellico M, Castro P. Encefalopatía hipóxico-isquémica. Medicine 1995;6:11-24.
15. Saunders GH, Penry JK. Phenobarbital/primidone: therapeutic use and serum concentration monitoring. In: Taylor WJ, Finn AL, editores. Individualizing drug therapy: practical applications of drug monitoring, New York: Gross, Townsend, Frank. Inc; 1981. p. 49-62.
16. Dawson-Saunders B. Bioestadística médica. México: El Manual Moderno; 1993. p. 115-41, 165-86.
17. st ed. Baltimore, MD, USA: William and Wilkins; 1993. p. 232.
18. st ed. Philadelphia, PA, USA: Lippincott; 1999. p. 1231-1252.
19. Ajayi OA, Oyaniyi OT, Chike-Obi UD, Ugonna D. Adverse effects of early phenobarbital administration in term newborns with perinatal asphyxia. Trop Med Int Health 1998;3:592-595.
20. Evans DJ, Levene MI. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. The Cochrane Library 2001;1:1-14.
21. Perlman JM, Riser R. Can asphyxiated infants at risk for with neonatal seizures be rapidly identified by current high risk markers?. Pediatrics 1996;97:456-462.