Differential activation and inhibition of human platelet thrombin receptors by structurally distinct α-, β- and γ-thrombin

Platelets

Volumn 15, Issue 3, 2004, Pages 155-166

  Soslau, Gerald ^a   Goldenberg, Seth J ^a,b   Class, Reiner ^a   Jameson, Bradford ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; ANTICOAGULANT AGENT; BETA THROMBIN; ENZYME; GAMMA THROMBIN; HIRUDIN; HISTONE H1; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; PROTEINASE INHIBITOR; PROTHROMBIN; THROMBIN; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE; TRYPSIN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; IN VITRO STUDY; PH; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION;

ALPHA 1-ANTITRYPSIN; FACTOR XA; HIRUDINS; HISTONES; HUMANS; HYDROLYSIS; KINETICS; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, THROMBIN; THROMBIN; TRYPSIN;

RICKETTSIA SP. PAR;

EID: 2442486445     PISSN: 09537104     EISSN: None     Source Type: Journal    
DOI: 10.1080/0953710042000199848     Document Type: Article

References (40)

1. Bezeaud A, Guillin M C. Enzymatic and nonemzymatic properties of human β-thrombin. J Biol Chem 1988; 263: 3576-81.
2. Brezniak D V, Brower M S, Witting J I, Walz D A, Fenton J W II. Human α- to ζ-thrombin cleavage occurs with neutrophil cathepsin G or chymotrypsin while fibrinogen clotting activity is retained. Biochemistry 1990; 29: 3536-42.
3. Soslau G, Class R, Morgan D A, Foster C, Lord S T, Marchese P, Ruggeri Z M. Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib. J Biol Chem 2001; 276: 21173-83.
4. Fujikawa K, Coan M H, Legaz M E, Davie E W. The mechanism of activation of bovine factor X (Stuart factor) by intrinsic and extrinsic pathways. Biochemistry 1974; 13: 5290-9.
5. Hultin M, Nemerson Y. Activation of factor X by factors IXa and VIII; a specific assay for factor IXa in the presence of thrombin-activated factor VIII. Blood 1978; 52: 928-40.
6. Silverberg S A, Nemerson Y, Zur M. J Biol Chem 1977; 252: 8481-8.
7. Stenflo J, Dahlback B. Vitamin K-dependent proteins in blood coagulation. In: Stamatoyannopoulos G, Majerus P W, Perlmutter R M, Varmus H, eds. The Molecular Basis of Blood Diseases, 3rd edn. Philadelphia, PA: W.B. Saunders Co., 2001: 579-613.
8. Fenton J W II, Landis B H, Walz D A, Finlayson J S. In: Lundblad R L, Fenton J W II, Mann K G, eds. Chemistry and Biology of Thrombin. Ann Arbor. MI: Ann Arbor Science Publishers; 1977; 43-70.
9. Boissel J P, Le Bonniec B, Rabiet M J, Labie D, Elion J. Covalent structures of beta and gamma autolytic derivatives of human alpha-thrombin. J Biol Chem 1984; 259: 5691-7.
10. Chang J Y. The structures and proteolytic specificities of autolysed human thrombin. Biochem J 1986; 240: 797-802.
11. Stone S R, Hofsteenge J. Basis for the reduced affinity of βT-and γT-thrombin for hirudin. Biochemistry 1991; 30: 3950-5.
12. Hofsteenge J, Braun P J, Stone S R. Enzymatic properties of proteolytic derivatives of human alpha-thrombin. Biochemistry 1988; 27: 2144-51.
13. Jackson C M. Mechanims of prothrombin activation. In: Colman R W, Hirsh J, Marder V J, Salzman E W, eds. Hemostasis and Thrombosis. Philadelphia, PA: JB Lippincott, 1987; 135-137.
14. Brower M S, Walz D A, Garry E E, Fenton J W II. Human neutrophil elastase alters human alpha-thrombin function: limited proteolysis near the gamma-cleavage site results in decreased fibrinogen clotting and platelet-stimulatory activity. Blood 1987; 69: 813-9.
15. Broze G J Jr, Tollefsen D M. Regulation of blood coagulation by protease inhibitors. In: Stamatoyannopoulos G, Majerus P W, Perlmutter, R M, Varmus H, eds. The Molecular Basis of Blood Diseases. 3rd edn. Philadelphia, PA: W.B. Saunders, 2001: 657-79.
16. Harpel P C. Blood proteolytic enzyme inbihibitors: their role in modulating blood coagulation and fibrinolytic enzyme pathways. In: Colman R W, Hirsh J, Marder V J, Salzman E W, eds. Hemostasis and Thrombosis. Philadelphia, PA: JB Lippincott, 1987: 219-34.
17. Hogg P J, Bock P E. Modulation of thrombin and heparin activities by fibrin. Thromb Haemost 1997; 77: 424-33.
18. Jandrot-Perrus M, Didry D, Guillin, M C, Nurden A T. Cross-linking of alpha and gamma-thrombin to distinct binding sites on human platelets. Eur J Biochem 1988; 174: 359-67.
19. Church F C, Pratt C W, Noyes C M, Kalayanamit T, Sherrill G B, Tobin R B, Meade J B. Structural and functional properties of human alpha-thrombin, phosphopyridoxylated α-thrombin, and γT-thrombin. Identification of lysyl residues in alpha-thrombin that are critical for heparin and fibrin(ogen) interactions. J Biol Chem 1989; 264: 18419-25.
20. Villanueva G B. Conformational differences between high clotting human α-thrombin and nonclotting γ-thrombin. Biochemistry 1981; 20: 6519-25.
21. Fasco M J, Fenton J W II. Human α-, β(T)-, γ(T)-thrombins. Fed Proc 1975; 34: 355.
22. Takahashi K, Aiken M, Fenton J W II, Walz D A. Thrombospondin fragmentation by α-thrombin and resistance to γ-thrombin. Biochem J 1984; 224: 673-6.
23. Vu T K, Hung D T, Wheaton V I, Coughlin S R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-68.
24. Kahn M L, Zheng Y W, Huang W, Bigornia V, Zheng D, Moff S, Farese R V, Tam C, Coughlin S R. A dual thrombin receptor system for platelet activation. Nature 1998; 394: 690-4.
25. Soslau G, Goldenberg S J, Class R. The three thrombin receptors on human platelets respond differentially to alpha-, beta-, and gamma-thrombin. FASEB J 2001; 15: A896.
26. Cardigan R, Williamson L M. The quality of platelets after storage for 7 days. Transfusion Med 2003; 13: 173-87.
27. Harlow E, Lane D. Antibodies: a Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1988: 471-510.
28. Chu N M, Janckila A J, Wallace J H, Yam L T. Assessment of a method for immunochemical detection of antigen on nitrocellulose membranes. J Histochem Cytochem 1989; 37: 257-63.
29. Walsh P N, Schmaier A H. Platelet-coagulation protein interactions. In: Colman R W, Hirsh J, Marder V J, Salzman E W, eds. Hemostasis and Thrombosis. Philadelphia, PA: JB Lippincott, 1987: 689-709.
30. Magnusson S. Thrombin and prothrombin. In: Boyer P D, ed. The Enzymes. New York, NY: Academic Press, 1971; 3: 277-321.
31. Fenton J W II. Thrombin Specificity. Ann NY Acad Sci 1981; 370: 468-95.
32. Xu W F, Anderson H, Whitmore T E, Presnell S R, Yee D P, Ching A, Gilbert T, Davie E W, Foster D C. Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci USA 1998; 95: 6642-6.
33. Bode W, Turk D, Karshikov A. The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci 1992; 1: 426-71.
34. Nystedt S, Emilsson K, Wahlestedt C, Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci USA 1994; 91: 9208-12.
35. Zwaal R F A, Comfurius P, Bevers E M. Platelet procoagulant activity and microvesicle formation. Its putative role in hemostasis and thrombosis. Biochim Biophys Acta 1992; 1180: 1-8.
36. Mann K G, Krishnaswamy S, Lawson J H. Surface-dependent hemostasis. Semin Hematol 1992; 29: 213-26.
37. Bouchard B A, Catcher C S, Thrash B R. Effector cell protease receptor-1, a platelet activation-dependent membrane protein, regulates prothrombinase-catalyzed thrombin generation. J Biol Chem 1997; 272: 9244-51.
38. Zhai X, Srivastava A, Drummond D C, Daleke D, Lentz B R. Phosphatidylserine binding alters the conformation and specifically enhances the cofactor activity of bovine factor Va. Biochemistry 2002; 41: 5675-84.
39. Wilkinson F H, Ahmad S S, Walsh P N. The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating complex. J Biol Chem 2002; 277: 5734-41.
40. Ascenzi P, Amiconi G, Coletta M, Lupidi G, Menegatti E, Onesti S, Bolognesi M. Binding of hirudin to human α-, β- and γ-thrombin. A comparative kinetic and thermodynamic study. J Mol Biol 1992; 225: 177-84.