Synthesis and pharmacological evaluation of piperidinoalkanoyl-1,2,3,4- tetrahydroisoquinoline derivatives as novel specific bradycardic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3049-3052

  Kubota, Hideki ^a   Watanabe, Toshihiro ^a   Kakefuda, Akio ^a   Masuda, Noriyuki ^a   Wada, Kouichi ^a   Ishii, Noe ^a   Sakamoto, Shuichi ^a   Tsukamoto, Shin Ichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Bradycardic agent; Cardiac disease; Myocardial ischemia; Zatebradine

Indexed keywords

TETRAHYDROISOQUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONSCIOUSNESS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GUINEA PIG; HEART RIGHT ATRIUM; ISOLATED HEART; MEAN ARTERIAL PRESSURE; NONHUMAN; RAT;

ANIMALS; BRADYCARDIA; CARDIOTONIC AGENTS; DRUG EVALUATION, PRECLINICAL; PIPERIDONES; RATS; TETRAHYDROISOQUINOLINES;

CAVIA;

EID: 2442457606     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.031     Document Type: Article

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