Clozapine in the treatment of obsessive-compulsive symptoms in schizophrenia patients: A case series study

Pharmacopsychiatry

Volumn 37, Issue 2, 2004, Pages 52-56

  Reznik, I ^a,b,c,d   Yavin, I ^a   Stryjer, R ^b   Spivak, B ^a,c   Gonen, N ^a,c   Strous, R ^b,c   Mester, R ^a,c   Weizman, A ^c   Kotler, M ^b,c  

^a NESS ZIONA MENTAL HEALTH CENTER   (Israel)

^b BEER YAAKOV MENTAL HEALTH CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d Clalit Health Services   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BIPERIDEN; CLOMIPRAMINE; CLONAZEPAM; CLOZAPINE; FLUOXETINE; FLUVOXAMINE; OXAZEPAM; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; TRIHEXYPHENIDYL;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; FEMALE; HUMAN; MALE; MONOTHERAPY; OBSESSIVE COMPULSIVE DISORDER; PREDICTION; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; ANTIPSYCHOTIC AGENTS; CLOZAPINE; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; OBSESSIVE-COMPULSIVE DISORDER; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SEX CHARACTERISTICS; TREATMENT OUTCOME;

EID: 2442449061     PISSN: 01763679     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-815525     Document Type: Article

References (41)

1. Allen L, Tejera C. Treatment of clozapine-induced obsessive-compulsive symptoms with sertraline (letter). Am J Psychiat 1994; 151: 1096-1097
2. Baker RW, Ames D, Umbricht DS, Chengappa KN, Schooler NR. Obsessive-compulsive symptoms in schizophrenia: a comparison of olanzapine and placebo. Psychopharmacol Bull 1996; 32: 89-93
3. Baker RW, Bermanzohn PC, Wirshing DA, Chengappa KNR. Obsessions, compulsions, clozapine, and risperidone. CNS Spectrums. 1997; 2: 26-36
4. Baker RW, Chengappa KN, Baird JW, Steingard S, Christ MA, Schooler NR. Emergence of obsessive compulsive symptoms during treatment with clozapine. J Clin Psychiat 1992; 53: 439-442
5. Berman I, Chang HH, Klegon DA. Is there a distinct subtype of obsessive-compulsive schizophrenia? Psychiatric Ann 1999; 30: 652-649
6. Berman I, Merson A, Viegner B, Losonczy MF, Pappas D, Green AI. Obsessions and compulsions as a distinct cluster of symptoms in schizophrenia: a neuropsychological study. J Nerv Ment Dis 1998; 186: 150-156
7. Bermanzohn PC, Porto L, Arlow P, Pollack S, Stronger R, Siris SG. Are some neuroleptic-refractory symptoms in schizophrenia really obsessions?. CNS Spectrums 1997; 2: 51-57
8. Biondi M, Fedele L, Arcangeli T, Pancheri P. Development of obsessive-compulsive symptoms during clozapine treatment in schizophrenia and its positive response to clomipramine (letter). Psychother Psychosom 1999; 68: 111-112
9. Bland RC, Newman SC, Orn H. Schizophrenia: lifetime comorbidity in a community sample. Acta Psychiat Scand 1987; 75: 383-391
10. Buckley PF, Sajatovic M, Meltzer HY. Treatment of delusional disorders with clozapine (letter). Am J Psychiat 1994; 151: 1394-1395
11. Burgy M. Clozapine and obsessive-compulsive symptoms in schizophrenia. A case history of one patient. Nervenarzt 1999; 70: 64-67
12. Cassady SL, Thaker GK. Addition of fluoxetine to clozapine) letter). Am J Psychiatry 1992; 149: 27
13. Centorrino F, Baldessarini RJ, Frankenburg FR, Kando J, Volpicelli SA, Flood JG. Serum levels of clozapine and norclozapine in patients treated with selective serotonin reuptake inhibitors. Am J Psychiat 1996; 153: 820-822
14. Chang HH, Berman I. Treatment issues for patients with schizophrenia who have obsessive-compulsive symptoms. Psychiatric Ann, 1999: 529-532
15. de Haan L, Linszen DH, Gorsira R. Clozapine and obsessions in patients with recent-onset schizophrenia and other psychotic disorders. J Clin Psychiat 1999; 60: 364-365
16. Eales MJ, Layeni AO. Exacerbation of obsessive-compulsive symptoms associated with clozapine) letter). Br J Psychiat 1994; 164: 687-688
17. Fenton WS, McGlashan TH. The prognostic significance of obsessive-compulsive symptoms in schizophreni. Am J Psychiat 1986; 143: 437-441
18. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). New York: New York State Psychiatric Institute, Biometrics Research, 1995
19. Ghaemi SN, Zarate CA, Popli AP, Pillay SS, Cole JO. Is there a relationship between clozapine and obsessive-compulsive disorder. A retrospective chart review? Compr Psychiat 1995; 36: 267-270
20. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleismann RL, Hill CL, Heninger GR, Charney DS. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS), I: development, use and reliability. Arch Gen Psychiat 1989; 46: 1006-1011
21. Hwang MY, Hollander E. Schizo-obsessive disorders. Psychiatr Ann 1993; 23: 396-401
22. Karno M, Golding JM, Sorenson SB, Burnbaum RA. The epidemiology of obsessive compulsive disorder in 5 U.S. communities. Arch Gen Psych 1988; 45: 1094-1099
23. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261-276
24. La Porta LD. More on obsessive-compulsive symptoms and clozapine. J Clin Psychiat 1994; 55: 312
25. Patel B, Tandon R. Development of obsessive-compulsive symptoms during clozapine treatment) letter). Am J Psychiat 1993; 150: 836
26. Patil VJ. Development of transient obsessive-compulsive symptoms during treatment with clozapine (letter). Am J Psychiat 1992; 149: 272
27. Poyurovsky M, Dorfman-Etrog P, Hermesh H, Munitz H, Tollefson GD, Weizman A. Beneficial effect of olanzapine in schizophrenic patients with obsessive-compulsive symptoms. Int Clin Psychopharmacol 2000; 15: 169-173
28. Poyurovsky M, Hermesh H, Weizman A. Fluvoxamine treatment in clozapine-induced obsessive-compulsive symptoms in schizophrenic patients. Clin Neuropharmacol 1996; 19: 305-313
29. Poyurovsky M, Hramenkov S, Isakov V, Rauchverger B, Modai I, Schneidman M, Fuchs C, Weizman A. Obsessive-compulsive disorder in hospitalized patients with chronic schizophrenia. Psychiatry Res 2001; 102: 49-57
30. Poyurovsky M, Weizman A. Beneficial effect of clozapine in schizophrenic patients with comorbid obsessive-compulsive symptoms (abstract. (Presented at the 150-th Annual Meeting of the APA. 1997 San Diego, Ca, USA, (b): 136:
31. Reznik I, Sirota P. Obsessive-compulsive symptoms in schizophrenia: a randomized controlled trial with SSRI's and neuroleptics. J Clin Psychopharmacol 2000; 20: 410-416
32. Reznik I, Mester R, Kotler M, Weizman A. Obsessive-compulsive schizophrenia: a new diagnostic entity. J Neuropsychiat Clin Neurosci 2001; 13: 115-116
33. Robinson S, Winnik HZ, Weiss AA. "Obsessive psychosis": justification for a separate clinical entity. Isr Ann Psychiatr Relat Discip 1976; 14: 39-48
34. Strous RD, Patel JK, Zimmet S, Green AI. Clozapine and paroxetine in the treatment of schizophrenia with obsessive-compulsive features (letter). Am J Psychiat 1999; 156: 973-974
35. Taflinsky T. Obsessive-compulsive symptoms in schizophrenic patients treated with clozapine (abstract). Eur Neuropsychopharmacol 2000; 36 (suppl): P.2.074
36. Tibbo P, Gendemann K. Improvement of obsessions and compulsions with clozapine in an individual with schizophrenia (letter). Can J Psychiatry 1999; 44: 1049-1050
37. Tibbo P, Warneke L. Obsessive-compulsive disorder in schizophrenia: epidemiologic and biologic overlap. J Psychiatry Neurosci 1999; 24: 15-24
38. Voruganti LNP, Tremblay C, Awad AG. A prospective study of obsessive-compulsive symptoms during clozapine therapy. [poster NR 504]. Presented at the 154-th Annual Meeting of APA. 2001 New Orleans, La., USA
39. Wetzel H, Anghelescu I, Szegedi A, Wiesner J, Weigmann H, Harter S, Hiemke C. Pharmacokinetic interactions of clozapine with selective serotonin reuptake inhibitors: differential effects of fluvoxamine and paroxetine in a prospective study. J Clin Psychopharmacol 1998; 18: 2-9
40. Young CR, Bostic JQ, McDonald CL. Clozapine and refractory obsessive-compulsive disorder: a case report. J Clin Psychopharmacol 1994; 14: 209-211
41. Zohar J. Is there room for a new diagnostic subtype - the schizo-obsessive subtype? CNS Spectrums 1997; 2: 49-50