TGF-β1, FGF-2, and receptor mRNA expression in suture mesenchyme and dura versus underlying brain in fusing and nonfusing mouse cranial sutures

Plastic and Reconstructive Surgery

Volumn 113, Issue 6, 2004, Pages 1675-1684

  Gosain, Arun K ^a,b   Recinos, René F ^a,b   Agresti, Michael ^a,b   Khanna, Ashwani K ^a,b  

^a Medical College of Wisconsin ^*

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 2; GROWTH FACTOR RECEPTOR; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ACTIN; ACTIVIN RECEPTOR 1; FGF2 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TGFB1 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRANIAL SUTURE; CYTOKINE PRODUCTION; DURA MATER; MALE; MESENCHYME; MOUSE; MOUSE STRAIN; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKULL SUTURE; TIME; ANIMAL; BRAIN; CRANIOFACIAL SYNOSTOSIS; FRONTAL BONE; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; UPREGULATION;

ACTINS; ACTIVIN RECEPTORS, TYPE I; ANIMALS; BRAIN; CRANIAL SUTURES; CRANIOSYNOSTOSES; DURA MATER; FIBROBLAST GROWTH FACTOR 2; FRONTAL BONE; MALE; MICE; MICE, INBRED STRAINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 2442421937     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PRS.0000117362.33347.43     Document Type: Article

References (28)

1. Lin, K., Nolen, A., Gampper, T. J., Jane, J. A., Opperman, L. A., and Ogle, R. C. Elevated levels of transforming growth factors beta 2 and beta 3 in lambdoid sutures from children with persistent plagiocephaly. Cleft Palate Craniofac. J. 34: 331, 1997.
2. Roth, D. A., Gold, L. I., Han, V. K., et al. Immunolocalization of transforming growth factor β1, β2, and β3 and insulin-like growth factor I in premature cranial suture fusion. Plast. Reconstr. Surg. 99: 300, 1997.
3. Cohen, M. M. Differential expression of fibroblast growth factor receptors in human digital development suggests common pathogenesis in complex acrosyndactyly and craniosynostosis (Discussion). Plast. Reconstr. Surg. 107: 1339, 2001.
4. Yu, P., Gosain, A. K., and Khanna, A. The role of transforming growth factor-beta in the modulation of mouse cranial suture fusion. Plast. Reconstr. Surg. 108: 916, 2001.
5. Greenwald, J. A., Mehrara, B. J., Spector, J. A., et al. In vivo modulation of FGF biological activity alters cranial suture fate. Am. J. Pathol. 158: 441, 2001.
6. Warren, S. M., Brunet, L. J., Economides, A. N., Harland, R. M., Fong, K. D., and Longaker, M. T. Apert and Crouzon fibroblast growth factor receptor gain-of-function mutations suppress noggin: A mechanism for FGF-2-mediated cranial suture fusion. Presented at the 47th Annual Meeting of the Plastic Surgery Research Council, Boston, Mass., April 2002.
7. Bradley, J. P., Levine, J. P., Roth, D. A., McCarthy, J. G., and Longaker, M. T. Studies in cranial suture biology IV: Temporal sequence of posterior frontal cranial suture fusion in the mouse. Plast. Reconstr. Surg. 98: 1039, 1996.
8. Moss, M. L. Fusion of the frontal suture in the rat. Am. J. Anat. 102: 141, 1958.
9. Moss, M. L. Inhibition and stimulation of sutural fusion in the rat calvaria. Anat. Rec. 136: 457, 1960.
10. Levine, J. P., Bradley, J. P., Roth, D. A., McCarthy, J. G., and Longaker, M. T. Studies in cranial suture biology: Regional dura mater determines overlying suture biology. Plast. Reconstr. Surg. 101: 1441, 1998.
11. Most, D., Levine, J., Chang, J., et al. Studies in cranial suture biology: Up-regulation of transforming growth factor-beta1 and basic fibroblast growth factor mRNA correlates with posterior frontal cranial suture fusion in the rat. Plast. Reconstr. Surg. 101: 1431, 1998.
12. Opperman, L. A., Nolen, A. A., and Ogle, R. C. TGF-beta 1, TGF-beta 2 and TGF-beta 3 exhibit distinct patterns of expression during cranial suture formation and obliteration in vivo and in vitro. J. Bone Miner. Res. 12: 301, 1997.
13. Frenkel, S. R., Herskovits, M. S., and Singh, I. J. Fibroblast growth factor: Effect on osteogenesis and chondrogenesis in the chick embryo. Acta Anat. (Basel) 145: 265, 1992.
14. Mayahara, H., Ito, T., Nagai, H., et al. In vivo stimulation of endosteal bone formation by basic fibroblast growth factor in rats. Growth Fact. 9: 73, 1993.
15. Kasperk, C. H., Wergedal, J. E., Mohan, S., Long, D. L., Lau, K. H., and Baylink, D. J. Interactions of growth factors present in bone matrix with bone cells: Effects on DNA synthesis and alkaline phosphatase. Growth Fact. 3: 147, 1990.
16. Spector, J. A., Greenwald, J. A., Warren, S. M., et al. Dura mater biology: Autocrine and paracrine effects of fibroblast growth factor 2. Plast. Reconstr. Surg. 109: 645, 2002.
17. Merino, R., Ganan, Y., Macias, D., Economides, A. N., Sampath, K. T., and Hurle, J. M. Morphogenesis of digits in the avian limb is controlled by FGFs, TGFfβs, and noggin through BMP signaling. Dev. Biol. 200: 35, 1998.
18. Centrella, M., Horowitz, M. C., Wozney, J. M., and McCarthy, T. L. Transforming growth factor-beta gene family members and bone. Endocrinol. Rev. 15: 27, 1994.
19. Mehrara, B. J., Mackool, R. J., McCarthy, J. G., Gittes, G. K., and Longaker, M. T. Immunolocalization of basic fibroblast growth factor and fibroblast growth factor receptor-1 and receptor-2 in rat cranial sutures. Plast. Reconstr. Surg. 102: 1805, 1998.
20. Hunenko, O., Karmacharya, J. Ong, G., and Kirschner, R. E. Toward an understanding of nonsyndromic craniosynostosis: Altered patterns of TGF-β receptor and FGF receptor expression induced by intrauterine head constraint. Ann. Plast. Surg. 46: 546, 2001.
21. Mehrara, B. J., Steinbrech, D. S., Saadeh, P. B., Gittes, G. K., and Longaker, M. T. Expression of high-affinity receptors for TGF-beta during rat cranial suture fusion. Ann. Plast. Surg. 42: 502, 1999.
22. Suzuki, T., Higgins, P. J., and Crawford, D. R. Control selection for RNA quantitation. Biotechniques 29: 332, 2000.
23. Sagiroglu, J. S., Mehrara, B. J., Chau, D., Saadeh, P. B., Gittes, G. K., and Longaker, M. T. Analysis of TGF-β production by fusing and nonfusing mouse cranial sutures in vitro. Ann. Plast. Surg. 42: 496, 1999.
24. Iseki, S., Wilke, A. O., Heath, J. K., et al. FGFR2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2. Development 124: 3375, 1997.
25. Iseki, S., Wilkie, A. O., and Morriss-Kay, G. M. FGFR1 and FGFR2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Development 126: 5611, 1999.
26. Recinos, R. F., Agresti, M., and Gosain, A. K. Real-time reverse transcriptase PCR is a sensitive, rapid, and reproducible means to detect mRNA levels in mouse cranial tissue. Presented at the 47th Annual Meeting of the Plastic Surgery Research Council, Boston, Mass., April 2002.
27. Opperman, L. A., Chhabra, A., Cho, R. W., and Ogle, R. C. Cranial suture obliteration is induced by removal of transforming growth factor (TGF)-beta 3 activity and prevented by removal of TGF-beta 2 activity from fetal rat calvaria in vitro. J. Craniofac. Genet. Dev. Biol. 19: 164, 1999.
28. Mehrara, B., Fernandez, et al. Adenovirus-mediated transmission of a dominant negative truncated transforming growth factor beta receptor inhibits in vitro mouse cranial suture fusion. Surg. Forum 49: 492, 1998.