Prenatal nicotine exposure recruits an excitatory pathway to brainstem parasympathetic cardioinhibitory neurons during hypoxia/hypercapnia in the rat: Implications for sudden infant death syndrome

Pediatric Research

Volumn 58, Issue 3, 2005, Pages 562-567

  Huang, Zheng Gui ^a   Wang, Xin ^a   Dergacheva, Olga ^a   Mendelowitz, David ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENT DYE; NICOTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APNEA; ARTICLE; BRADYCARDIA; BRAIN STEM; CHOLINERGIC SYSTEM; CIGARETTE SMOKING; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROPHYSIOLOGY; FATALITY; HEART RATE; HYPERCAPNIA; HYPOGLOSSAL NERVE; HYPOXIA; NERVE CELL EXCITABILITY; NEUROCHEMISTRY; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PATCH CLAMP; PREGNANT WOMAN; PRENATAL EXPOSURE; PREVALENCE; PRIORITY JOURNAL; RAT; SUDDEN INFANT DEATH SYNDROME; SYNAPSE; SYNAPTIC TRANSMISSION; TOBACCO; VAGUS NERVE;

ANIMALS; ANOXIA; BRAIN STEM; FEMALE; HEART; HUMANS; HYPERCAPNIA; INFANT, NEWBORN; NEURONS; NICOTINE; PARASYMPATHETIC NERVOUS SYSTEM; PATCH-CLAMP TECHNIQUES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; SUDDEN INFANT DEATH;

EID: 24344499536     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000179380.41355.FC     Document Type: Article

References (40)

1. Hathorn MK 1987 Respiratory sinus arrhythmia in new-born infants. J Physiol 385:1-12
2. Hirsch JA, Bishop B 1981 Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate. Am J Physiol 241:H620-H629
3. Bouairi E, Neff R, Evans C, Gold A, Andresen MC, Mendelowitz D 2004 Respiratory sinus arrhythmia in freely moving and anesthetized rats. J Appl Physiol 97:1431-1436
4. Anrep G, Pascual W, Rossler R 1936 Respiratory variations of the heart rate. II. The central mechanism of the respiratory sinus arrhythmia and the inter-relations between the central and the reflex mechanisms. Proc R Soc 119:218-232
5. Anrep G, Pascual W, Rossler R 1936 Respiratory variations of the heart rate. I. The mechanism of respiratory arrhythmia reflex. Proc R Soc 119:119-217
6. Daly MD 1991 Some reflex cardioinhibitory responses in the cat and their modulation by central inspiratory neuronal activity. J Physiol 439:559-577
7. Shykoff BE, Naqvi SS, Menon AS, Slutsky AS 1991 Respiratory sinus arrhythmia in dogs. Eifects of phasic aiferents and chemostimulation. J Clin Invest 87:1621-1627
8. Inoue K, Miyake S, Kumashiro M, Ogata H, Yoshimura O 1990 Power spectral analysis of heart rate variability in traumatic quadriplegic humans. Am J Physiol 258:H1722-H1726
9. Warner MR, deTarnowsky JM, Whitson CC, Loeb JM 1986 Beat-by-beat modulation of AV conduction. II. Autonomic neural mechanisms. Am J Physiol 251:H1134-H1142
10. Guntheroth WG, Kawabori I 1975 Hypoxic apnea and gasping. J Clin Invest 56:1371-1377
11. Gozal D, Gozal E, Reeves SR, Lipton AJ 2002 Gasping and autoresuscitation in the developing rat: effect of antecedent intermittent hypoxia. J Appl Physiol 92:1141-1144
12. Guntheroth WG, Kawabori I 1975 Hypoxia apnea and gasping. J Clin Invest 56:1371-1377
13. Deshpande P, Khurana A, Hansen P, Wilkins D, Thach BT 1999 Failure of autoresuscitation in weanling mice: significance of cardiac glycogen and heart rate regulation. J Appl Physiol 87:203-210
14. Schuen JN, Barnford OS, Carroll JL 1997 The cardiorespiratory response to anoxia: normal development and the effect of nicotine. Respir Physiol 109:231-239
15. Schuen JN, Bamford OS, Carroll JL 1997 The cardiorespiratory response to anoxia: normal development and the effect of nicotine. Respir Physiol 109:231-239
16. Anderson RN 2002 Deaths: leading causes for 2000. Natl Vital Stat Rep 50:1-85
17. Hunt CE 2001 Sudden infant death syndrome and other causes of infant mortality: diagnosis, mechanisms, and risk for recurrence in siblings. Am J Respir Crit Care Med 164:346-357
18. Meny RG, Carroll JL, Carbone MT, Kelly DH 1994 Cardiorespiratory recordings from infants dying suddenly and unexpectedly at home. Pediatrics 93:44-49
19. Mitchell EA, Ford RP, Stewart AW, Taylor BJ, Becroft DM, Thompson JM, Scragg R, Hassall IB, Barry DM, Allen EM, et al 1993 Smoking and the sudden infant death syndrome. Pediatrics 91:893-896
20. Haglund B, Cnattingius S 1990 Cigarette smoking as a risk factor for sudden infant death syndrome: a population-based study. Am J Public Health 80:29-32
21. Slotkin TA, Epps TA, Stenger ML, Sawyer KJ, Seidler FJ 1999 Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality. Brain Res Dev Brain Res 113:1-12
22. Slotkin TA, Saleh JL, McCook EC, Seidler FJ 1997 Impaired cardiac function during postnatal hypoxia in rats exposed to nicotine prenatally: implications for perinatal morbidity and mortality, and for sudden infant death syndrome. Teratology 55: 177-184
23. Smith JC, Ellenberger HH, Ballanyi K, Richter DW, Feldman JL 1991 Pre-Botzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254:726-729
24. Mendelowitz D, Kunze DL 1991 Identification and dissociation of cardiovascular neurons from the medulla for patch clamp analysis. Neurosci Lett 132:217-221
25. Wang J, Iraaten M, Venkatesan P, Evans C, Baxi S, Mendelowitz D 2002 Synaptic activation of hypoglossal respiratory motoraeurons during inspiration in rats. Neurosci Lett 332:195-199
26. Telgkamp P, Ramirez JM 1999 Differential responses of respiratory nuclei to anoxia in rhythmic brain stem slices of mice. J Neurophysiol 82:2163-2170
27. Lieske SP, Thoby-Brisson M, Telgkamp P, Ramirez JM 2000 Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs, and gasps. Nat Neurosci 3:600-607
28. Bamford OS, Schuen JN, Carroll JL 1996 Effect of nicotine exposure on postnatal ventilatory responses to hypoxia and hypercapnia. Respir Physiol 106:1-11
29. Simakajoraboon N, Vlasic V, Li H, Sawnani H 2004 Effect of prenatal nicotine exposure on biphasic hypoxic ventilatory response and protein kinase C expression in caudal brain stem of developing rats. J Appl Physiol 96:2213-2219
30. Lewis KW, Bosque EM 1995 Deficient hypoxia awakening response in infants of smoking mothers: possible relationship to sudden infant death syndrome. J Pediatr 127:691-699
31. Ueda Y, Stick SM, Hall G, Sly PD 1999 Control of breathing in infants born to smoking mothers. J Pediatr 135:226-232
32. Gilbey MP, Jordan D, Richter DW, Spyer KM 1984 Synaptic mechanisms involved in the inspiratory modulation of vagal cardio-inhibitory neurones in the cat. J Physiol 356:65-78
33. Neff RA, Wang J, Baxi S, Evans C, Mendelowitz D 2003 Respiratory sinus arrhythmia: endogenous activation of nicotinic receptors mediates respiratory modulation of brainstem cardioinhibitory parasympathetic neurons. Circ Res 93:565-572
34. Garrigue S, Bordier P, Jais P, Shah DC, Hocini M, Raherison C, Tunon De Lara M, Haissaguerre M, Clementy J 2002 Benefit of atrial pacing in sleep apnea syndrome. N Engl J Med 346:404-412
35. Tilkian AG, Guilleminault C, Schroeder JS, Lehrman KL, Simmons FB, Dement WC 1977 Sleep-induced apnea syndrome. Prevalence of cardiac arrhythmias and their reversal after tracheostomy. Am J Med 63:348-358
36. Fewell JE, Smith FG, Ng VK, Wong VH, Wang Y 2000 Postnatal age influences the ability of rats to autoresuscitate from hypoxic-induced apnea. Am J Physiol 279:R39-R46
37. Neff RA, Simmens SJ, Evans C, Mendelowitz D 2004 Prenatal nicotine exposure-alters central cardiorespiratory responses to hypoxia in rats: implications for sudden infant death syndrome. J Neurosci 24:9261-9268
38. Poets CF, Meny RG, Chobanian MR, Bonofiglo RE 1999 Gasping and other cardiorespiratory patterns during sudden infant deaths. Pediatr Res 45: 350-354
39. Huang ZG, Wang X, Evans C, Gold A, Bouairi E, Mendelowitz D 2004 Prenatal nicotine exposure alters the types of nicotinic receptors that facilitate excitatory inputs to cardiac vagal neurons. J Neurophysiol 92:2548-2554
40. Buisson B, Bertrand D 2001 Chronic exposure to nicotine upregulates the human (alpha)4(beta)2 nicotinic acetylcholine receptor function. J Neurosci 21:1819-1829