Antihypertensive and endothelium-dependent vasodilator effects of Alpinia zerumbet, a medicinal plant

Journal of Cardiovascular Pharmacology

Volumn 46, Issue 3, 2005, Pages 288-294

  Soares De Moura, R ^a   Emiliano, A F ^a   Marins De Carvalho, L C R ^a   Souza, M A V ^a   Guedes, D C ^a   Tano, T ^a   Resende, A C ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Alpinia zerumbet; Antihypertensive; Endothelium; Vasodilation

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINOPYRIDINE; ACETYLCHOLINE; ALPINIA ZERUMBET EXTRACT; APAMIN; BRADYKININ RECEPTOR; CHARYBDOTOXIN; CLONIDINE; CYCLIC GMP; DEOXYCORTICOSTERONE ACETATE; GLIBENCLAMIDE; GUANYLATE CYCLASE; HISTAMINE; ICATIBANT; INDOMETACIN; MEPYRAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NORADRENALIN; PLANT EXTRACT; POTASSIUM CHANNEL; UNCLASSIFIED DRUG; YOHIMBINE;

ALPINIA; ALPINIA ZERUMBET; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; MALE; MEDICINAL PLANT; MESENTERY BLOOD VESSEL; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

ACETYLCHOLINE; ALPINIA; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DESOXYCORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENDOTHELIUM, VASCULAR; HYPERTENSION; MALE; MESENTERIC ARTERIES; PLANT EXTRACTS; RATS; VASODILATOR AGENTS;

EID: 24344494861     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000175239.26326.47     Document Type: Article

References (25)

1. Correia MP. Dicionário de Plantas Uteis do Brasil, vols 3-4. Rio de Janeiro, Brazil: Ministério da Agricultura IBDF, 1978.
2. Matos FJA. Farmáçias vivas. In: Matos FJA, ed. Colônia. Fortaleza, Ceará, Brazil: Imprensa Universitária, 2001:206-207.
3. Mendonça VLM, Oliveira CLA, Craveiro AA, et al. Pharmacological and toxicological evaluation of Alpinia speciosa. Mem Inst Oswaldo Cruz. 1991;86:93-97.
4. Mpalatinos MA, Soares de M, Parente JP, et al. Biologically active flavonoids and kava pyrones from the aqueous extract of Alpinia zerumbet. Phytother Res. 1998;12:442-444.
5. Stoclet J-C, Chataigneau T, Ndiaye M, et al. Vascular protection by dietary polyphenols. Eur J Pharmacol. 2004;500:299-313.
6. Soares de Moura R, Miranda DZ, Pinto ACA, et al. Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilan red wine. J Cardiovasc Pharmacol. 2004;44:302-309.
7. Soares de Moura R, Costa Viana FS, Souza MAV et al. Antihypertensive, vasodilator and antioxidant effects of a vinifera grape skin extract. J Pharm Pharmacol. 2002;54:1515-1520.
8. Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enot Vitic. 1965;16:144-158.
9. McGregor DD. The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric blood vessels of the rat. J Physiol. 1965;177:21-30.
10. G-Nitro arginine (L-Noarg), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br J Pharmacol. 1990;99:408-412.
11. SJW, Hill A, Waldron GJ, et al. The relative importance of nitric oxide and nitric oxide-independent mechanisms in acetylcholine-evoked dilatation of the rat mesenteric bed. Br J Pharmacol. 1994;113:1275-1280.
12. Shibata T, Ogawa K, Ito T, et al. Role of cyclic GMP of canine vascular smooth muscle in relaxation by organic nitrates. Jpn Circ J. 1986;50: 1091-1099.
13. Khan MT, Jothiaanandan D, Matsunaga, et al. Vasodilation induced by acetylcholine and by glyceryl trinitrate in rat aortic and mesenteric vasculature. J Vasc Res. 1992;29:20-28.
14. Yamawaki H, Sato K, Hori M, et al. Platelet-derived growth factor causes endothelium-independent relaxation of rabbit mesenteric artery via release of a prostanoid. Br J Pharmacol. 2000;131:1546-1552.
15. Peredo HA, Adler-Graschinsky E. Effects of eicosanoids and nitric oxide on the noradrenaline-induced contractions in the rat mesenteric bed. J Auton Pharmacol. 2000;20:162-170.
16. Vanhoutte PM. Endothelial dysfunction and vascular disease. In: Panza JA, Cannon RO III, eds. Endothelium, Nitric Oxide, and Atherosclerosis. Armonk, NY: Futura Publishing Co. Inc. 1999:79-95.
17. Vanhoutte PM, Mombouli JV Vascular endothelium: vasoactive mediators. Prog Cardiovasc Dis. 1996;39:229-238.
18. Rees DD, Palmer RMJ, Hodson HF, et al. A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol. 1989;96:418-424.
19. Nadiaye M, Chataigneau M, Lobysheva I, et al. Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J. 2005;19: 455-457.
20. Murad F. Cyclic GMP synthesis and function. Pharmacol Rev. 1987;39: 163-196.
21. Tare M, Parkington HC, Coleman HA, et al. Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from endothelium. Nature. 1990;346:69-71.
22. Wallerath T, Witte K, Schäfer SC, et al. Down-regulation of the expression of endotheloal NO synthase is likely to contribute to glucocorticoid-mediated hypertension. Proc Natl Acad Sci USA. 1999;96:13357-13362.
23. Pinto YM, Paul M, Ganten D. Lessons from rat models of hypertension: from Goldblatt to genetic engineering. Cardiovasc Res. 1998;39: 77-88.
24. Lahlou S, Interaminense LF, Leal-Cardoso JH, et al. Antihypertensive effects of the essential oil of Alpinia zerumbet and its main constituint, terpinem-4-ol, in DOCA-salt hypertensive conscious rats. Fundam Clin Pharmacol. 2003;17:323-330.
25. Waterhouse AL. Wine phenolics. Ann N Y Acad Sci. 2002;957:21-36.