The effects of the antiresorptive agents calcitonin and pamidronate on spine fusion in a rabbit model

Spine Journal

Volumn 5, Issue 5, 2005, Pages 542-547

  Babat, L Brett ^a   McLain, Robert ^a   Milks, Ryan ^a   Ferrara, Lisa ^a   Sohn, Moon Jun ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Animal model; Bisphosphonate; Calcitonin; Spine fusion

Indexed keywords

CALCITONIN; PAMIDRONIC ACID;

AGING; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRODESIS; ARTICLE; BONE GRAFT; BONE REMODELING; CONTROLLED STUDY; DRUG SAFETY; FISHER EXACT TEST; ILIAC CREST; INFUSION PUMP; LUMBAR SPINE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PEROPERATIVE CARE; POSTOPERATIVE CARE; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RABBIT; RIGIDITY; SPINE FUSION;

ANIMALS; BIOMECHANICS; BONE DENSITY CONSERVATION AGENTS; BONE REMODELING; CALCITONIN; DIPHOSPHONATES; LUMBAR VERTEBRAE; RABBITS; SPINAL FUSION; TENSILE STRENGTH;

EID: 24344483491     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2005.01.008     Document Type: Article

References (23)

1. D. Black S. Cummings D. Karpf et al. Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures Lancet 348 1996 1535-1541
2. U. Leiberman S. Weiss J. Broll et al. Effect of oral alendronate on bone mineral density and the incidence of fracture in postmenopausal oateoporotic women N Engl J Med 333 1995 1437-1443
3. J. Lane Osteoporosis: Medical prevention and treatment Spine 22 24S 1997 32S-37S
4. C. Li S. Mori J. Li et al. Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats J Bone Min Res 16 3 2001 429-436
5. C. Li S. Mori Y. Kaji et al. Effect of bisphosphonate (incadronate) on fracture healing of long-bones in rats J Bone Min Res 14 6 1999 969-979
6. T. Lenehan M. Balligand D. Nunamaker et al. Effect of EHDP on fracture healing in dogs J Orthop Res 3 1985 499-507
7. C. Peter W. Cook D. Nunamaker et al. Effect of alendronate on fracture healing and bone remodeling in dogs J Orthop Res 14 1 1996 74-79
8. A. Fitton D. McTavish Pamidronate: A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease Drugs 41 1991 289-318
9. J. Schatzger M. Chapman G. Ha'Eri et al. The effect of calcitonin on fracture healing Clin Orthop 141 1979 303-306
10. P. Paavolainen T. Taivainen J. Michelsson et al. Calcitonin and fracture healing: An experimental study on rats Orthop Res 7 1989 100-106
11. J. Lane M. Nydick Osteoporosis: Current modes of prevention and treatment J Am Acad Orthop Surg 7 1 1999 19-31
12. S. Boden J. Schimandle W. Hutton An experimental lumbar intertransverse process spinal fusion model: Radiographic, histologic, and biomechanical healing characteristics Spine 20 4 1995 412-420
13. C.H. Chesnut M.R. McClung K.E. Ensrud et al. Alendronate treatment of the postmenopausal osteoporotic woman: Effect of multiple dosages on bone mass and bone remodelling Am J Med 99 1995 144-152
14. U.A. Liberman S.R. Weiss J. Broll et al. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis N Engl J Med 333 1995 1437-1443
15. V.V. Povoroznjuk E.I. Bayandina P.I. Nikonenko et al. Alendronate treatment of the postmenopausal osteoporotic woman with vertebral fractures Bone 22 1998 B68
16. D.M. Black S.R. Cummings D.B. Karpf et al. Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures Lancet 348 1996 1535-1541
17. H.A.P. Pols D. Felsenberg D.A. Hanley Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: Results of the FOSIT study Osteoporosis Int 9 1999 461
18. D.B. Karpf D.R. Shapiro E. Seeman et al. Prevention of non-vertebral fractures by alendronate: A meta-analysis JAMA 277 1997 1159-1164
19. D.R. Shapiro D.E. Thompson D.B. Karpf et al. Non-vertebral fracture incidence in patients treated with alendronate J Bone Min Res 10 1995 A150
20. Osteoporosis prevention, diagnosis, and therapy. National Institutes of Health Consensus Statement, March 27-29, 2000;17(1).
21. R. Lehman T. Kuklo B. Freedman et al. The effect of alendronate sodium on spinal fusion: A rabbit model Spine J 4 2004 36-43
22. G. Martin S. Boden L. Titus Recombinant human bone morphogenetic protein-2 overcomes the inhibitory effect of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), on posterolateral lumbar intertransverse process spine fusion Spine 24 21 1999 2188-2194
23. Bae H, Yee A, Friess D, et al, Alendronate influences bone volume in rabbit posterolateral spine fusion. Paper presented at: 17th Annual North American Spine Society Meeting; October 30-November 2, 2002; Montreal, Quebec, Canada.