Methotrexate-induced status epileticus

American Journal of Hematology

Volumn 80, Issue 1, 2005, Pages 35-37

  Naing, Aung ^a   Luong, Don ^a   Extermann, Martine ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Central nervous system; Leukemia; Methotrexate; Seizure; Status epilepticus; Toxicity

Indexed keywords

AMINOPHYLLINE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; HYDROCORTISONE; LORAZEPAM; METHOTREXATE; MITOXANTRONE; PHENYTOIN; PROPOFOL; SODIUM CHLORIDE; TOPOTECAN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE TOXICITY; ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ANTICONVULSANT THERAPY; ARACHNOIDITIS; ARTICLE; BRAIN DYSFUNCTION; BRAIN NECROSIS; CANCER RADIOTHERAPY; CASE REPORT; CENTRAL NERVOUS SYSTEM METASTASIS; COMPUTER ASSISTED TOMOGRAPHY; CRANIAL NERVE PARALYSIS; DROWSINESS; DRUG DELIVERY SYSTEM; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; HEMIPARESIS; HEMIPLEGIA; HUMAN; INTRACRANIAL HYPERTENSION; INTUBATION; LEUKEMIC MENINGITIS; LEUKOENCEPHALOPATHY; MALE; NAUSEA; NEUROTOXICITY; PRIORITY JOURNAL; SEIZURE; SOMNOLENCE; VOMITING;

ANTIMETABOLITES, ANTINEOPLASTIC; CYTARABINE; HUMANS; INJECTIONS, INTRAVENTRICULAR; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; METHOTREXATE; MIDDLE AGED; STATUS EPILEPTICUS; TREATMENT OUTCOME;

EID: 24344481230     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20365     Document Type: Article

References (20)

1. Castagnola C, Nozza A, Corso A, Bernasconi C. The value of combination therapy in adult acute myeloid leukemia with central nervous system involvement. Haematologia 1977;82:577.
2. Sullivan MP, Vietti TJ, Fernbach DJ, Griffith KM, Haddy TB, Watkins WL. Clinical investigations in the treatment of meningeal leukemia: radiation regimens vs. conventional intrathecal methotrexate. Blood 1969;34:301-319.
3. Pochedly C. Prophylactic CNS therapy in childhood acute leukemia. Review of methods used. Am J Pediatr Hematol Oncol 1979;1:119-126.
4. Bleyer WA. Neurologic sequelae of methotrexate and ionizing radiation: a new classification. Cancer Treat Rep 1981;65(Suppl 1):89-98.
5. Ravid R, Swanson JW, Dejesus RS, Hunt CH, Tefferi A. Methotrexate-induced seizure associated with acute reversible magnetic resonance imaging changes in a patient with acute lymphoblastic leukemia. Leuk Lymphoma 2002;43:1333-1336.
6. Johnson LF, Fuhrman CL, Albert HT. Resistance of resting 3T6 mouse fibroblasts to methotrexate cytotoxicity. Cancer Res 1978;38:2408-2412.
7. Gregorios JB, Soucy D. Effects of methotrexate on astrocytes in primary culture: light and electron microscopic studies. Brain Res 1990;516:20-30.
8. Phillips PC, Dhawan V, Strother SC, et al. Reduced cerebral glucose metabolism and increased brain capillary permeability following high-dose methotrexate chemotherapy: a positron emission tomographic study. Ann Neurol 1987;21:59-63.
9. Nakagaki H, Brunhart G, Kemper TL, et al. Monkey brain damage from radiation in the therapeutic range. J Neurosurg 1976;44:3-11.
10. Duttera MJ, Bleyer WA, Pomeroy TC, Leventhal CM, Leventhal BG. Irradiation, methotrexate toxicity, the treatment of meningeal leukemia. Lancet 1973(Sep 29);2(7831):703-707.
11. Bleyer WA, Drake JC, Chabner BA. Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in meningeal leukemia. New Engl J Med 1973;289:770-774.
12. Phillips PC, Thaler HT, Berger CA, et al. Acute high-dose methotrexate toxicity in the rat. Ann Neurol 1986;20:583-589.
13. Millot F, Chastagner P, Dhondt J, Sommelet D. Substitute therapy in a case of methotrexate neurotoxicity. Eur J Cancer 1992;28(11):1935.
14. Cronstein BN. The pharmacology of the anti-inflammatory agents. A new paradigm. Mt Sinai J Med 1993;60:209-217.
15. Bernini JC, Fort DW, Griener JC, Kane BJ, Chappell WB, Kamen BA. Aminophylline for methotrexate-induced neurotoxicity. Lancet 1995;345:544-554.
16. Abelson AT. Methotrexate and central nervous system toxicity. Cancer Treat Rep 1978;12:1999-2001.
17. Kishi S, Griener J, Cheng C, et al. Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia. J Clin Oncol 2003;21:3084-3091.
18. Finkelstein Y, Zevin S, Heyd J, Bentur Y, Zigelman Y, Hersch M. Emergency treatment of life-threatening intrathecal methotrexate overdose. Neurotoxicology 2004;25:407-410.
19. Rao RD, Swanson JW, Dejesus RS, Hunt CH, Tefferi A. Methotrexate induced seizures associated with acute reversible magnetic resonance imaging (MRI) changes in a patient with acute lymphoblastic leukemia. Leuk Lymphoma 2002;43:1333-1336.
20. Ochs JJ, Bowman WP, Pui CH, Abromowitch M, Mason C, Simone JV. Seizures in childhood lymphoblastic leukemia patients. Lancet 1984;22(8417-8418):1422- 1424.