Lung transplantation: Donor and recipient critical care aspects

Current Opinion in Critical Care

Volumn 11, Issue 4, 2005, Pages 339-344

  Pierre, Andrew F ^a   Keshavjee, Shaf ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Donor care; Extracorporeal membrane oxygenation; Lung transplantation; Non heart beating donor; Recipient care

Indexed keywords

DONOR; EXTRACORPOREAL OXYGENATION; GRAFT DYSFUNCTION; HUMAN; INTENSIVE CARE; LUNG TRANSPLANTATION; MORBIDITY; ORGAN PRESERVATION; POSTOPERATIVE CARE; POSTOPERATIVE PERIOD; RECIPIENT; REPERFUSION INJURY; REVIEW; RISK ASSESSMENT; TREATMENT OUTCOME;

BODY SIZE; CRITICAL CARE; DELAYED GRAFT FUNCTION; DONOR SELECTION; EXTRACORPOREAL MEMBRANE OXYGENATION; HUMANS; LIVING DONORS; LUNG TRANSPLANTATION; ORGAN PRESERVATION; PATIENT SELECTION; PERIOPERATIVE CARE; REPERFUSION INJURY; RISK ASSESSMENT; TISSUE DONORS;

EID: 24344434218     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/01.ccx.0000170507.55443.90     Document Type: Review

References (46)

1. Toronto Lung Transplant Group. Unilateral lung transplantation for pulmonary fibrosis. N Engl J Med 1986; 314:1140-1145.
2. Trulock EP, Edwards LB, Taylor DO, et al. The Registry of the International Society for Heart and Lung Transplantation: twenty-first official adult lung and heart-lung transplant report- 2004. J Heart Lung Transplant 2004; 23:804-815. This report documents indications and outcomes for lung transplantation from the entire international experience. It serves as an excellent overview of outcomes and morbidity spanning more than 20 years.
3. Sundaresan S, Trachiotis GD, Aoe M, et al. Donor lung procurement: assessment and operative technique. Ann Thorac Surg 1993; 56:1409-1413.
4. Sundaresan S, Semenkovich J, Ochoa L, et al. Successful outcome of lung transplantation is not compromised by the use of marginal donor lungs. J Thorac Cardiovasc Surg 1995; 109:1075-1079.
5. Kawut SM, Reyentovich A, Wilt JS, et al. Outcomes of extended donor lung recipients after lung transplantation. Transplantation 2005; (3)79:310-316. This paper is further evidence that the use of extended donor lungs may not affect survival but may affect morbidity.
6. Pierre AF, Sekine Y, Hutcheon MA, et al. Marginal donor lungs: a reassessment. J Thorac Cardiovasc Surg 2002; 123:421-427.
7. de Perrot M, Snell GI, Babcock WD, et al. Strategies to optimize the use of currently available lung donors. J Heart Lung Transplant 2004; 23:1127-1134. This excellent review details the treatment of the multiorgan donor for lung transplant and discusses how to select extended or marginal donor lungs.
8. Orens JB, Boehler A, de Perrot M, et al. A review of lung transplant donor acceptability criteria. J Heart Lung Transplant 2003; 22:1183-1200.
9. Couetil JP, Tolan MJ, Loulmet DF, et al. Pulmonary bipartitioning and lobar transplantation: a new approach to donor organ shortage. J Thorac Cardiovasc Surg 1997; 113:529-537.
10. Aigner C, Mazhar S, Jaksch P, et al. Lobar transplantation, split lung transplantation and peripheral segmental resection: reliable procedures for downsizing donor lungs. Eur J Cardiothorac Surg 2004; 25:179-183.
11. Aigner C, Winkler G, Jaksch P, et al. Size-reduced lung transplantation: an advanced operative strategy to alleviate donor organ shortage. Transplant Proc 2004; 36:2801-2805.
12. Starnes VA, Barr ML, Cohen RG. Lobar transplantation: indications, technique, and outcome. J Thorac Cardiovasc Surg 1994; 108:403-410.
13. Date H, Aoe M, Sano Y, et al. Improved survival after living-donor lobar lung transplantation. J Thorac Cardiovasc Surg 2004; 128:933-940. This paper describes the Japanese experience with live-donor lung transplantation. No deaths during follow-up care suggest improved survival, but the follow-up time was relatively short.
14. Starnes VA, Bowdish ME, Woo MS, et al. A decade of living lobar lung transplantation: recipient outcomes. J Thorac Cardiovasc Surg 2004; 127:114-122. This paper describes the largest experience with live-donor lung transplantation. Outcomes with long-term follow-up are reported.
15. Meyers BF, Lynch J, Trulock EP, et al. Lung transplantation: a decade of experience. Ann Surg 1999; 230:362-370.
16. Bowdish ME, Pessotto R, Barbers RG, et al. Long-term pulmonary function after living-donor lobar lung transplantation in adults. Ann Thorac Surg 2005; 79:418-425. This paper shows that lung function of lobar transplants is essentially equivalent to that of whole cadaveric lungs.
17. Bowdish ME, Barr ML, Schenkel FA, et al. A decade of living lobar lung transplantation: perioperative complications after 253 donor lobectomies. Am J Transplant 2004; 4:1283-1288. Donor risks are carefully documented in this report on live-donor lung procurement.
18. Patterson GA. Living lobar lung transplantation: is it a necessary option? Am J Transplant 2004; 4:1213-1214.
19. Egan TM. Non-heart-beating donors in thoracic transplantation. J Heart Lung Transplant 2004; 23:3-10. This paper provides a comprehensive discussion of the rationale behind NHBD lung donation and a review of the experimental work to date.
20. Hennington MH, D'Armini AM, Lemasters JJ, Egan TM. Cadaver lungs for transplantation: effect of ventilation with alveolar gas. Transplantation 1996; 61:1009-1014.
21. Rega FR, Jannis NC, Verleden GM, et al. Should we ventilate or cool the pulmonary graft inside the non-heart-beating donor? J Heart Lung Transplant 2003; 22:1226-1233.
22. Steen S, Ingemansson R, Budrikis A, et al. Successful transplantation of lungs topically cooled in the non-heart-beating donor for 6 hours. Ann Thorac Surg 1997; 63:345-351.
23. Steen S, Sjoberg T, Pierre L, et al. Transplantation of lungs from a non-heart-beating donor. Lancet 2001; 357:825-829.
24. Rega FR, Jannis NC, Verleden GM, et al. Long-term preservation with interim evaluation of lungs from a non-heart-beating donor after a warm ischemic interval of 90 minutes. Ann Surg 2003; 238:782-792.
25. Fischer S, Matte-Martyn A, De Perrot M, et al. Low-potassium dextran preservation solution improves lung function after human lung transplantation. J Thorac Cardiovasc Surg 2001; 121:594-596.
26. Gamez P, Cordoba M, Millan I, et al. Improvements in lung preservation: 3 years' experience with a low-potassium dextran solution. Arch Bronconeumol 2005; 41:16-19. This is one of many papers over the years to suggest that the extracellular solution low-potassium dextran is superior to the intracellular solutions for lung preservation.
27. Sommer SP, Warnecke G, Hohlfeld JM, et al. Pulmonary preservation with LPD and celsior solution in porcine lung transplantation after 24 h of cold ischemia. Eur J Cardiothorac Surg 2004; 26:151-157.
28. Maurer JR, Frost AE, Estenne M, et al. International guidelines for the selection of lung transplant candidates. The International Society for Heart and Lung Transplantation, the American Thoracic Society, the American Society of Transplant Physicians, the European Respiratory Society. Transplantation 1998; 66:951-956.
29. de Perrot M, Keshavjee S. Everting mattress running suture: an improved technique of atrial anastomosis in human lung transplantation. Ann Thorac Surg 2002; 73:1663-1664.
30. Pierre AF, DeCampos KN, Liu M, et al. Rapid reperfusion causes stress failure in ischemic rat lungs. J Thorac Cardiovasc Surg 1998; 116:932-942.
31. Christie JD, Bavaria JE, Palevsky HI, et al. Primary graft failure following lung transplantation. Chest 1998; 114:51-60.
32. King RC, Binns OA, Rodriguez F, et al. Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation. Ann Thorac Surg 2000; 69:1681-1685.
33. de Perrot M, Liu M, Waddell TK, Keshavjee S. Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 2003; 167:490-511.
34. Shargall Y, Guenther G, Ahyan V, et al. Treatment of primary graft failure (PGF) after lung transplantation. J Heart Lung Transplant 2005 (in press).
35. Keshavjee S, Davis RD, Zamora MR, et al. A randomized, placebo-controlled trial of complement inhibition in ischemia-reperfusion injury after lung transplantation in human beings. J Thorac Cardiovasc Surg 2005; 129:423-428. This paper reports one of only a few randomized multicenter studies on reperfusion lung injury. Some benefit was seen with complement inhibition.
36. Meade MO, Granton JT, Matte-Martyn A, et al. A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation. Am J Respir Crit Care Med 2003; 167:1483-1489.
37. Aoe M, Trachiotis GD, Okabayashi K, et al. Administration of prostaglandin E1 after lung transplantation improves early graft function. Ann Thorac Surg 1994; 58:655-661.
38. DeCampos KN, Keshavjee S, Liu M, Slutsky AS. Prevention of rapid reperfusion-induced lung injury with prostaglandin E1 during the initial period of reperfusion. J Heart Lung Transplant 1998; 17:1121-1128.
39. Matsuzaki Y, Waddell TK, Puskas JD, et al. Amelioration of post-ischemic lung reperfusion injury by prostaglandin E1. Am Rev Respir Dis 1993; 148:882-889.
40. de Perrot M, Fischer S, Liu M, et al. Prostaglandin E1 protects lung transplants from ischemia-reperfusion injury: a shift from pro- to anti-inflammatory cytokines. Transplantation 2001; 72:1505-1512.
41. de Perrot M, Imai Y, Volgyesi GA, et al. Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model. J Thorac Cardiovasc Surg 2002; 124:1137-1144.
42. Dahlberg PS, Prekker ME, Herrington CS, et al. Medium-term results of extracorporeal membrane oxygenation for severe acute lung injury after lung transplantation. J Heart Lung Transplant 2004; 23:979-984. Although this paper reports a relatively small number of cases, it adds to the growing experience with ECMO for lung transplant primary graft failure and shows acceptable outcomes in selected patients.
43. Fiser SM, Kron IL, McLendon Long S, et al. Early intervention after severe oxygenation index elevation improves survival following lung transplantation. J Heart Lung Transplant 2001; 20:631-636.
44. Meyers BF, Sundt TM 3rd, Henry S, et al. Selective use of extracorporeal membrane oxygenation is warranted after lung transplantation. J Thorac Cardiovasc Surg 2000; 120:20-26.
45. Oto T, Rosenfeldt F, Rowland M, et al. Extracorporeal membrane oxygenation after lung transplantation: evolving technique improves outcomes. Ann Thorac Surg 2004; 78:1230-1235. This study highlights the importance of early intervention if ECMO is going to be successful in primary graft failure.
46. Sekine Y, Waddell TK, Matte-Martyn A, et al. Risk quantification of early outcome after lung transplantation: donor, recipient, operative, and posttransplant parameters. J Heart Lung Transplant 2004; 23:96-104. This paper identifies multiple preoperative and postoperative factors that are then used to calculate a risk index score, which may be helpful in treating lung transplant patients and in comparing results from center to center.