메뉴 건너뛰기




Volumn 36, Issue 3, 2005, Pages 513-537

Integrating research and development: The emergence of rational drug design in the pharmaceutical industry

Author keywords

Biomedicine; Corporate research; Experiment; Interaction model; Pharmacology; Sir James Black

Indexed keywords

CAPTOPRIL; LOSARTAN; PROPRANOLOL;

EID: 24144498743     PISSN: 13698486     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.shpsc.2005.07.003     Document Type: Article
Times cited : (28)

References (61)
  • 1
  • 3
    • 24144440304 scopus 로고
    • The predictive value of animal tests in relation to drugs affecting the cardiovascular system in man
    • G. Wolstenholme & R. Porter (Eds.) Churchill London
    • J.W. Black The predictive value of animal tests in relation to drugs affecting the cardiovascular system in man In G. Wolstenholme & R. Porter (Eds.) Drug responses in man 1967 Churchill London pp 111-124
    • (1967) Drug Responses in Man , pp. 111-124
    • Black, J.W.1
  • 4
    • 0017073993 scopus 로고
    • Ahlquist and the development of beta-adrenoreceptor antagonists
    • J.W. Black Ahlquist and the development of beta-adrenoreceptor antagonists Postgraduate Medical Journal 52 Suppl. 4 1976 11-13
    • (1976) Postgraduate Medical Journal , vol.52 , Issue.SUPPL. 4 , pp. 11-13
    • Black, J.W.1
  • 5
    • 0024396459 scopus 로고
    • Drugs from emasculated hormones: The principle of syntopic antagonism
    • J.W. Black Drugs from emasculated hormones: The principle of syntopic antagonism Science 245 1989 486-493
    • (1989) Science , vol.245 , pp. 486-493
    • Black, J.W.1
  • 8
    • 0004113802 scopus 로고
    • Washington, D.C.: United States Government Printing Office
    • V. Bush Science: The endless frontier 1945 United States Government Printing Office Washington, D.C.
    • (1945) Science: The Endless Frontier
    • Bush, V.1
  • 9
    • 0015932710 scopus 로고
    • Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A
    • L.D. Byers & R. Wolfenden Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A Biochemistry 12 1973 2070-2078
    • (1973) Biochemistry , vol.12 , pp. 2070-2078
    • Byers, L.D.1    Wolfenden, R.2
  • 12
    • 24144484573 scopus 로고
    • (repr. ed.) Berlin: Springer. (First published 1937)
    • A.J. Clark General pharmacology repr. ed. 1970 Springer Berlin (First published 1937)
    • (1970) General Pharmacology
    • Clark, A.J.1
  • 13
    • 0038005668 scopus 로고    scopus 로고
    • The diffusion of science driven drug discovery: Organizational change in pharmaceutical research
    • National Bureau of Economic Research Working Paper, 7359 (Last accessed 5 May 2004)
    • Cockburn, I. M., Henderson, R., & Stern, S. (1999). The diffusion of science driven drug discovery: Organizational change in pharmaceutical research. National Bureau of Economic Research Working Paper, 7359. http://www.nber.org/papers/w7359. (Last accessed 5 May 2004).
    • (1999)
    • Cockburn, I.M.1    Henderson, R.2    Stern, S.3
  • 14
    • 0017584729 scopus 로고
    • Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids
    • D.W. Cushman H.S. Cheung E.F. Sabo et al. Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids Biochemistry 16 1977 5484-5491
    • (1977) Biochemistry , vol.16 , pp. 5484-5491
    • Cushman, D.W.1    Cheung, H.S.2    Sabo, E.F.3
  • 16
    • 0019994445 scopus 로고
    • Development and design of specific inhibitors of angiotensin-converting enzyme
    • D.W. Cushman H.S. Cheung E.F. Sabo et al. Development and design of specific inhibitors of angiotensin-converting enzyme American Journal of Cardiology 49 1982 1390-1394
    • (1982) American Journal of Cardiology , vol.49 , pp. 1390-1394
    • Cushman, D.W.1    Cheung, H.S.2    Sabo, E.F.3
  • 17
    • 0025881724 scopus 로고
    • History of the design of captopril and related inhibitors of angiotensin converting enzyme
    • D.W. Cushman & M.A. Ondetti History of the design of captopril and related inhibitors of angiotensin converting enzyme Hypertension 17 1991 589-592
    • (1991) Hypertension , vol.17 , pp. 589-592
    • Cushman, D.W.1    Ondetti, M.A.2
  • 18
    • 0015693946 scopus 로고
    • Inhibition of angiotensin-converting enzyme by analogs of peptides from Bothrops jararaca venom
    • D.W. Cushman J. Pluščec N.J. Williams Inhibition of angiotensin-converting enzyme by analogs of peptides from Bothrops jararaca venom Experientia 29 1973 1032-1035
    • (1973) Experientia , vol.29 , pp. 1032-1035
    • Cushman, D.W.1    Pluščec, J.2    Williams, N.J.3
  • 19
    • 0007372655 scopus 로고    scopus 로고
    • The endless transition: A 'triple helix' of university-industry-government relations
    • H. Etzkowitz & L. Leydesdorff The endless transition: A 'triple helix' of university-industry-government relations Minerva 36 1998 203-208
    • (1998) Minerva , vol.36 , pp. 203-208
    • Etzkowitz, H.1    Leydesdorff, L.2
  • 20
    • 0014959663 scopus 로고
    • Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom
    • S.H. Ferreira D.C. Bartelt & L.J. Greene Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom Biochemistry 9 1970 2583-2593
    • (1970) Biochemistry , vol.9 , pp. 2583-2593
    • Ferreira, S.H.1    Bartelt, D.C.2    Greene, L.J.3
  • 21
    • 0014960193 scopus 로고
    • Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzyme
    • S.H. Ferreira L.J. Greene V.A. Alabaster Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzyme Nature 225 1970 379-380
    • (1970) Nature , vol.225 , pp. 379-380
    • Ferreira, S.H.1    Greene, L.J.2    Alabaster, V.A.3
  • 22
    • 0013848094 scopus 로고
    • Potentiation of bradykinin and eledoisin by BPF (bradykinin potentiating factor) from Bothrops jararaca venom
    • S.H. Ferreira & M. Rocha e Silva Potentiation of bradykinin and eledoisin by BPF (bradykinin potentiating factor) from Bothrops jararaca venom Experientia 21 1965 347-349
    • (1965) Experientia , vol.21 , pp. 347-349
    • Ferreira, S.H.1    Rocha e Silva, M.2
  • 23
    • 6844242100 scopus 로고
    • Side effects associated with inhibitors of angiotensin-converting enzyme
    • J.I. Robertson & M.G. Nicholls (Eds.) Mosby London
    • A.E. Fletcher & C.T. Dollery Side effects associated with inhibitors of angiotensin-converting enzyme In J.I. Robertson & M.G. Nicholls (Eds.) The renin-angiotensin system 1993 Mosby London pp 99.1-99.15
    • (1993) The Renin-Angiotensin System
    • Fletcher, A.E.1    Dollery, C.T.2
  • 25
    • 0004026556 scopus 로고
    • The new production of knowledge. The dynamics of science and research in contemporary societies
    • London: Sage
    • M. Gibbons C. Limoges H. et al. Nowotny The new production of knowledge. The dynamics of science and research in contemporary societies 1994 Sage London
    • (1994)
    • Gibbons, M.1    Limoges, C.2    Nowotny, H.3
  • 26
    • 0013112994 scopus 로고    scopus 로고
    • Rethinking mechanistic explanation
    • S. Glennan Rethinking mechanistic explanation Philosophy of Science 69 Suppl. 2002 S342-S353
    • (2002) Philosophy of Science , vol.69 , Issue.SUPPL.
    • Glennan, S.1
  • 27
    • 0034581968 scopus 로고    scopus 로고
    • High-throughput and virtual screening: Core lead discovery technologies move towards integration
    • A. Good S.R. Krystek & J.S. Mason High-throughput and virtual screening: Core lead discovery technologies move towards integration Drug Discovery Today 5 12, Suppl. 2000 S61-S69
    • (2000) Drug Discovery Today , vol.5 , Issue.12 SUPPL.
    • Good, A.1    Krystek, S.R.2    Mason, J.S.3
  • 28
    • 84857636390 scopus 로고    scopus 로고
    • Can it ever be pure science? Pharmaceuticals, the pharmaceutical industry and biomedical research in the twentieth century
    • J.-P. Gaudillière & I. Löwy (Eds.) Macmillan London
    • J. Goodman Can it ever be pure science? Pharmaceuticals, the pharmaceutical industry and biomedical research in the twentieth century In J.-P. Gaudillière & I. Löwy (Eds.) The invisible industrialist 1998 Macmillan London pp 143-166
    • (1998) The Invisible Industrialist , pp. 143-166
    • Goodman, J.1
  • 31
    • 0001267367 scopus 로고
    • Angiotensin-converting enzyme inhibitors
    • J.I. Robertson & M.G. Nicholls (Eds.) Mosby London
    • C.I. Johnston Angiotensin-converting enzyme inhibitors In J.I. Robertson & M.G. Nicholls (Eds.) The renin-angiotensin system 1993 Mosby London pp 87.1-87.15
    • (1993) The Renin-Angiotensin System
    • Johnston, C.I.1
  • 34
    • 0010582621 scopus 로고    scopus 로고
    • The technoeconomic network: A socioeconomic approach to intervention in innovation
    • R. Coombs A. Richards & P.P. Saviotti (Eds.) Elgar Cheltenham
    • P. Larédo & P. Mustar The technoeconomic network: A socioeconomic approach to intervention in innovation In R. Coombs A. Richards P.P. Saviotti (Eds.) Technological innovation. The dynamics of cooperation in industrial innovation 1996 Elgar Cheltenham pp 143-164
    • (1996) Technological Innovation. The Dynamics of Cooperation in Industrial Innovation , pp. 143-164
    • Larédo, P.1    Mustar, P.2
  • 35
    • 0347349496 scopus 로고
    • Chemistry and biomedicine in an industrial setting: The invention of the sulfa drugs
    • S.H. Mauskopf (Ed.) University of Pennsylvania Press Philadelphia
    • J.E. Lesch Chemistry and biomedicine in an industrial setting: The invention of the sulfa drugs In S.H. Mauskopf (Ed.), Chemical sciences in the modern world 1993 University of Pennsylvania Press Philadelphia pp 158-215
    • (1993) Chemical Sciences in the Modern World , pp. 158-215
    • Lesch, J.E.1
  • 36
    • 0021258349 scopus 로고
    • The state of the art of the science of drug discovery - An opinion
    • R.A. Maxwell The state of the art of the science of drug discovery - an opinion Drug Development Research 4 1984 375-389
    • (1984) Drug Development Research , vol.4 , pp. 375-389
    • Maxwell, R.A.1
  • 39
    • 0028792103 scopus 로고
    • Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist
    • M. Mizuno T. Sada M. Ikeda et al. Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist European Journal of Pharmacology 285 1995 181-188
    • (1995) European Journal of Pharmacology , vol.285 , pp. 181-188
    • Mizuno, M.1    Sada, T.2    Ikeda, M.3
  • 41
    • 0014412538 scopus 로고
    • Fate of angiotensin I in the circulation
    • K.K.F. Ng & J.R. Vane Fate of angiotensin I in the circulation Nature 218 1968 144-150
    • (1968) Nature , vol.218 , pp. 144-150
    • Ng, K.K.F.1    Vane, J.R.2
  • 43
    • 84857635697 scopus 로고
    • Press Release: The 1988 Nobel Prize in physiology or medicine
    • Nobel Assembly (Last accessed 5 May 2004)
    • Nobel Assembly (1988). Press Release: The 1988 Nobel Prize in physiology or medicine. Nobel Assembly at the Karolinska Institute, http://www.nobel.se/medicine/laureates/1988/press.html. (Last accessed 5 May 2004).
    • (1988) Nobel Assembly at the Karolinska Institute
  • 44
    • 0015241466 scopus 로고
    • Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesis
    • M.A. Ondetti N. Williams E.F. Sabo et al. Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesis Biochemistry 10 1971 4033-4039
    • (1971) Biochemistry , vol.10 , pp. 4033-4039
    • Ondetti, M.A.1    Williams, N.2    Sabo, E.F.3
  • 47
    • 79958703927 scopus 로고    scopus 로고
    • Black, James White (Last accessed 5 May 2004)
    • Quirke, V. (2001). Black, James White. In Encyclopedia of Life Sciences. http://www.els.net. (Last accessed 5 May 2004).
    • (2001) Encyclopedia of Life Sciences
    • Quirke, V.1
  • 48
    • 24144446889 scopus 로고
    • Myocardial metabolism in the pathogenesis and treatment of angina pectoris
    • W. Raab Myocardial metabolism in the pathogenesis and treatment of angina pectoris Cardiologia 22 1953 291-303
    • (1953) Cardiologia , vol.22 , pp. 291-303
    • Raab, W.1
  • 49
    • 0001824005 scopus 로고
    • Renin and angiotensin: A historical review
    • J.I. Robertson & M.G. (Eds.) Nicholls Mosby London
    • J.I. Robertson Renin and angiotensin: A historical review In J.I. Robertson & M.G. Nicholls (Eds.) The renin-angiotensin system 1993 Mosby London pp 1.1-1.18
    • (1993) The Renin-Angiotensin System
    • Robertson, J.I.1
  • 50
    • 84936103687 scopus 로고
    • Critical issues in science policy research
    • N. Rosenberg Critical issues in science policy research Science and Public Policy 18 1991 335-346
    • (1991) Science and Public Policy , vol.18 , pp. 335-346
    • Rosenberg, N.1
  • 51
    • 2042485983 scopus 로고
    • The discovery of beta adrenoreceptor blocking drugs
    • M.J. Parnham & J. Bruinvels (Eds.) Elsevier Amsterdam
    • R.G. Shanks The discovery of beta adrenoreceptor blocking drugs In M.J. Parnham & J. Bruinvels (Eds.), Discoveries in pharmacology Haemodynamics, hormones & inflammation Vol.2 1984 Elsevier Amsterdam pp 37-72
    • (1984) Discoveries in Pharmacology. Haemodynamics, Hormones & Inflammation , vol.2 , pp. 37-72
    • Shanks, R.G.1
  • 53
    • 0037699010 scopus 로고    scopus 로고
    • The Discovery of Captopril
    • C.G. Smith & J.R. Vane The Discovery of Captopril FASEB Journal 17 2003 788-789
    • (2003) FASEB Journal , vol.17 , pp. 788-789
    • Smith, C.G.1    Vane, J.R.2
  • 57
    • 0028862783 scopus 로고
    • Discovery of losartan, the first angiotensin II receptor antagonist
    • P.B. Timmermans J.V. Duncia D.J. et al. Carini Discovery of losartan, the first angiotensin II receptor antagonist Journal of Human Hypertension 9 Suppl. 5 1995 S3-S18
    • (1995) Journal of Human Hypertension , vol.9 , Issue.SUPPL. 5
    • Timmermans, P.B.1    Duncia, J.V.2    Carini, D.J.3
  • 58
    • 0003621404 scopus 로고
    • Drugs looking for diseases. Innovative drug research and the development of the beta blockers and the calcium antagonists
    • Dordrecht: Kluwer
    • R. Vos Drugs looking for diseases. Innovative drug research and the development of the beta blockers and the calcium antagonists 1991 Kluwer Dordrecht
    • (1991)
    • Vos, R.1
  • 59
    • 0012428310 scopus 로고    scopus 로고
    • Industrial R&D and its influence on the organization and management of the production of knowledge in the public sector
    • J.-P. Gaudillière & I. Löwy (Eds.) Macmillan London
    • V. Walsh Industrial R&D and its influence on the organization and management of the production of knowledge in the public sector In J.-P. Gaudillière I. Löwy (Eds.), The invisible industrialist 1998 Macmillan London pp 301-344
    • (1998) The Invisible Industrialist , pp. 301-344
    • Walsh, V.1
  • 61
    • 0024421343 scopus 로고
    • Preliminary biochemical characterization of two angiotensin II receptor subtypes
    • White, S., Mele, M., Kamber, et al. (1989). Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochemical and Biophysical Research Communication, 163, 284-291.
    • (1989) Biochemical and Biophysical Research Communication , vol.163 , pp. 284-291
    • White, S.1    Mele, M.2    Kamber3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.