Epinephrine overdose-associated hypokalemia and rhabdomyolysis in a newborn

Pharmacotherapy

Volumn 25, Issue 9, 2005, Pages 1266-1270

  Fang, Wen ^a   Chen, Ju Yi ^b   Fang, Yun ^c   Huang, Jing Long ^a,b,d  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d CHANG GUNG CHILDREN S HOSPITAL   (Taiwan)

Author keywords

Epinephrine; Hypokalemia; Medication error; Newborn; Rhabdomyolysis

Indexed keywords

ADRENALIN; BICARBONATE; CREATINE KINASE; FUROSEMIDE; POTASSIUM CHLORIDE;

ANEMIA; ARTICLE; ARTIFICIAL VENTILATION; CASE REPORT; CREATINE KINASE BLOOD LEVEL; DRUG OVERDOSE; EARLY DIAGNOSIS; ELECTROLYTE BALANCE; ERYTHROCYTE TRANSFUSION; FEMALE; HOSPITAL PATIENT; HUMAN; HYDRATION; HYPOKALEMIA; LABORATORY TEST; MEDICATION ERROR; METABOLIC ACIDOSIS; MUSCLE INJURY; NEWBORN; NEWBORN INTENSIVE CARE; NURSE; PATHOPHYSIOLOGY; RHABDOMYOLYSIS; TACHYCARDIA; TREATMENT OUTCOME;

ADRENERGIC AGONISTS; EPINEPHRINE; FEMALE; HUMANS; HYPOKALEMIA; INFANT, NEWBORN; MEDICATION ERRORS; OVERDOSE; RHABDOMYOLYSIS;

EID: 24144489491     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.2005.25.9.1266     Document Type: Article

References (27)

1. Ved SA, Pinosky M, Nicodemus H. Ventricular tachycardia and brief cardiovascular collapse in two infants after caudal anesthesia using a bupivacaine-epinephrine solution. Anesthesiology 1993;79:1121-3.
2. Caldwell CC, Levkoff AH, Purohit DM. Paroxysmal supraventricular tachycardia in a neonate: a complication of racemic epinephrine inhalation for post-extubation stridor. Clin Pediatr 1977;16:579-80.
3. Levine DH, Levkoff AH, Pappu LD, Purohit DM. Renal failure and other serious sequelae of epinephrine toxicity in neonates. South Med J 1985;78:874-7.
4. Demon J, Schreiner RL, Pearson J. Circumcision complication reaction to treatment of local hemorrhage with topical epinephrine in high concentration. Clin Pediatr 1978;17:285-6.
5. Davis CO, Wax PM. Prehospital epinephrine overdose in a child resulting in ventricular dysrhythmias and myocardial ischemia. Pediatr Emerg Care 1999;15:116-18.
6. Liu HP, Wu KC, Lu PP, et al. Delayed-onset epinephrine-induced pulmonary edema. Anesthesiology 1999;91:1169-70.
7. Solomon SL, Wallace EM, Ford-Jones EL, et al. Medication errors with inhalant epinephrine mimicking an epidemic of neonatal sepsis. N Engl J Med 1984;310:166-70.
8. Germanakis I, Bender C, Hentschel R, Braun K, Dittrich S, Kececioglu D. Hypercontractile heart failure caused by catecholamine therapy in premature neonates. Acta Paediatr 2003;92:836-8.
9. Woodard ML, Brent LD. Acute renal failure, anterior myocardial infarction, and atrial fibrillation complicating epinephrine abuse. Pharmacotherapy 1998;18:656-8.
10. Brunjes S, Castner E, Hodgman J. Catecholamine metabolism in newborn infants [abstr]. Clin Res 1964;12:88.
11. 2- receptor stimulation by circulating epinephrine. N Engl J Med 1983;309:1414-19.
12. 2-receptor stimulation by circulating epinephrine. Am J Cardiol 1985;58:3D-9.
13. Reid JL, Whyte KF, Struthers AD. Epinephrine-induced hypokalemia: the role of β adrenoceptors. Am J Cardiol 1986;57:23F-7.
14. Connell JM, Cook GM, McInnes GT. Metabolic consequences of salbutamol poisoning reversed by propranolol. Br Med J 1982;285:779.
15. + transport in skeletal muscles. Physiol Rev 1986;66:542-80.
16. Sterns RH, Spital A. Disorders of internal potassium balance. Semin Nephrol 1987;7:399-415.
17. Bradberry SM, Vale JA. Disturbances of potassium homeostasis in poisoning. J Toxicol Clin Toxicol 1995;33:295-310.
18. Gabow PA, Kaehny WD, Kelleher SP. The spectrum of rhabdomyolysis. Medicine 1982;61:141-52.
19. Warren JD, Blumbergs PC, Thompson PD. Rhabdomyolysis: a review. Muscle Nerve 2002;25:332-47.
20. Visweswaran P, Guntupalli J. Rhabdomyolysis. Crit Care Clin 1999;15:415-28.
21. Singhal PC, Abramovici M, Venkatesan J, Mattana J. Hypokalemia and rhabdomyolysis. Miner Electrolyte Metab 1991;17:335-9.
22. Allison RC, Bedsole DL. The other medical causes of rhabdomyolysis. Am J Med Sci 2003;326:79-88.
23. Dybvik T, Halvorsen P, Steen PA. Accidental intravenous administration of 50 mg of racemic adrenaline in a 2-year-old boy. Eur J Anaesthesiol 1995;12:181-3.
24. Kaushal R, Bates DW, Landrigan C, et al. Medication errors and adverse drug events in pediatric inpatients. JAMA 2001;285:2114-20.
25. Bates DW, Boyle DL, Vander Vliet MB, Schneider J, Leape L. Relationship between medication errors and adverse drug events. J Gen Intern Med 1995;10:199-205.
26. Folli HL, Poole RL, Benitz WE, Russo JC. Medication error prevention by clinical pharmacists in two children's hospitals. Pediatrics 1987;79:718-22.
27. Simpson JH, Lynch R, Grant J, Alroomi L. Reducing medication errors in the neonatal intensive care unit. Arch Dis Child Fetal Neonatal Ed 2004;89:F480-2.