Identification of nitrated proteins in the normal rat brain using a proteomics approach

Neurological Research

Volumn 27, Issue 6, 2005, Pages 630-633

  Suzuki, Yoko ^a   Tanaka, Makoto ^a   Sohmiya, Makoto ^a   Ichinose, Sachiyo ^b   Omori, Akira ^b   Okamoto, Koichi ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

Author keywords

Clathrin heavy chain; Nitrated protein; Proteomics; Rat brain; T complex polypeptide 1 subunit

Indexed keywords

CLATHRIN HEAVY CHAIN; GLIAL FIBRILLARY ACIDIC PROTEIN; NITRATED PROTEIN; PROTEIN; PROTEIN SUBUNIT; T COMPLEX POLYPEPTIDE 1ALPHA SUBUNIT; UNCLASSIFIED DRUG;

AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; NEUROFILAMENT; NITRATION; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; PROTEOMICS; RAT;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; BRAIN CHEMISTRY; CEREBRAL CORTEX; CHAPERONINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLATHRIN HEAVY CHAINS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; NEUROFILAMENT PROTEINS; NITRATES; PROTEOMICS; RATS; RATS, WISTAR;

EID: 24144487120     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164105X22039     Document Type: Article

References (15)

1. Shin CM, Chung YH, Kim MJ, et al. Age-related changes in the distribution of nitrotyrosine in the cerebral cortex and hippocampus of rats. Brain Res 2002; 931: 194-199
2. Bruijn LI, Beal MF, Becher MW, et al. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proc Natl Acad Sci USA 1997; 94: 7606-7611
3. Beal MF, Ferrante RJ, Browne SE, et al. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol 1997; 42: 644-654
4. Good PF, Hsu A, Werner P, et al. Protein nitration in Parkinson's disease. J Neuropathol Exp Neurol 1998; 57: 338-342
5. Castegna A, Thongboonkerd V, Klein JB, et al. Proteomic identification of nitrated proteins in Alzheimer's disease brain. J Neurochem 2003; 856: 1394-1401
6. Tohgi H, Abe T, Yamazaki K, et al. Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease. Neurosci Lett 1999; 269: 52-54
7. Beal MF. Oxidatively modified proteins in aging and disease. Free Radic Biol Med 2002; 32: 797-803
8. Greenacre SA, Ischiropoulos H. Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction. Free Radic Res 2001; 34: 541-581
9. Gole MD, Souza JM, Choi I, et al. Plasma proteins modified by tyrosine nitration in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2000; 278: L961-967
10. Omori A, Ichinose S, Kitajima S, et al. Gerbils of a seizure-sensitive strain have a mitochondrial inner membrane protein with different isoelectric points from those of a seizure-resistant strain. Electrophoresis 2002; 23: 4167-4174
11. Ikezono T, Omori A, Ichinose S, et al. Identification of the protein product of the Coch gene (hereditary deafness gene) as the major component of bovine inner ear protein. Biochim Biophys Acta 2001; 1535: 258-265
12. Schuller E, Gulesserian T, Seidl R, et al. Brain t-complex polypeptide 1 (TCP-1) related to its natural substrate betal tubulin is decreased in Alzheimer's disease. Life Sci 2001; 69: 263-270
13. Ihara Y, Yasuoka C, Kageyama K, et al. Tyrosine phosphorylation of clathrin heavy chain under oxidative stress. Biochem Biophys Res Commun 2002; 297: 353-360
14. Nakamura Y, Hasimoto R, Kashiwagi Y, et al. Abnormal distribution of neurofilament L in neurons with Alzheimer's disease. Neurosci Lett 1997; 225: 201-204
15. Strong MJ. Neurofilament metabolism in sporadic amyotrophic lateral sclerosis. J Neurol Sci 1999; 169: 170-177