2,4-Diaminopteridine-based compounds as precursors for de novo synthesis of antifolates: A novel class of antimalarials

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 9, 2005, Pages 3652-3657

  Nduati, Eunice ^a   Hunt, Sonya ^d   Kamau, Eddy M ^a   Nzila, Alexis ^a,b,c  

^a KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 6 HYDROXYMETHYLPTERIDINE; 2,4 DIAMINO N10 METHYLPTEROIC ACID; 2,4 DIAMINOPTERIDINE DERIVATIVE; 2,4 DIAMINOPTEROIC ACID; AMINOPTERIN; ANTIMALARIAL AGENT; CHLORCYCLOGUANIL; DAPSONE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; METHOTREXATE; PTERIDINE DERIVATIVE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; FUNGAL STRAIN; HYPOTHESIS; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ANIMALS; ANTIMALARIALS; DAPSONE; DIHYDROPTEROATE SYNTHASE; DRUG COMBINATIONS; DRUG SYNERGISM; FOLIC ACID ANTAGONISTS; PLASMODIUM; PTERIDINES; SACCHAROMYCES CEREVISIAE; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

EID: 24144466520     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.9.3652-3657.2005     Document Type: Article

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