In vitro and in vivo effects of soluble, monovalent globotriose on bacterial attachment and colonization

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 9, 2005, Pages 3842-3846

  Leach, James L ^a   Garber, Stacey A ^a   Marcon, Andrea A ^a   Prieto, Pedro A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; GLOBOTRIOSE; GLYCOLIPID; OLIGOSACCHARIDE; TRIOSE; TRISACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIUM ADHERENCE; BOLUS INJECTION; CELL AGGLUTINATION; CELL IMMORTALIZATION; COLON MUCOSA; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXCRETION; DRUG HALF LIFE; ERYTHROCYTE; ESCHERICHIA COLI; FEMALE; FIMBRIA; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TARGET CELL; URINARY TRACT INFECTION; UROTHELIUM;

AGGLUTINATION TESTS; ANIMALS; ATTACHMENT SITES, MICROBIOLOGICAL; BACTERIA; BIOLOGICAL AVAILABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; ESCHERICHIA COLI; FEMALE; FLOW CYTOMETRY; HALF-LIFE; HUMANS; MICE; MICE, INBRED BALB C; SOLUBILITY; TRISACCHARIDES;

EID: 24144451770     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.9.3842-3846.2005     Document Type: Article

References (18)

1. Ferry, S., L. G. Burman, and S. E. Holm. 1998. Clinical and bacteriological effects of therapy of urinary tract infection in primary health care: relation to in vitro sensitivity testing. Scand. J. Infect. Dis. 20:535-544.
2. Hopkins, W. J., J. A. Hall, B. P. Conway, and D. T. Uehling. 1995. Induction of urinary tract infection by intraurethral inoculation with Escherichia coli: refining the murine model. J. Infect. Dis. 171:462-465.
3. Hultgren, S. J., S. Abraham, M. Caparon, P. Falk, J. W. St. Geme, and S. Normark. 1993. Pilus and nonpilus bacterial adhesins: assembly and function in cell recognition. Cell 73:887-901.
4. Kihlberg, J., S. J. Hultgren, S. Mormark, and G. Magnusson. 1989. Probing of the combining site of the PapG adhesin of uropathogenic Escherichia col bacteria by synthetic analogues of galabiose. J. Am. Chem. Soc. 111:6364-6368.
5. Kitov, P. I., J. M. Sadowska, G. Mulvey, G. D. Armstrong, H. Ling, N. J. Pannu, R. J. Read, and D. R. Bundle. 2000. Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands. Nature 403:669-672.
6. Koizumi, S., T. Endo, K. Tabata, and A. Ozaki. 1998. Large-scale production of UDP-galactose and globotriose by coupling metabolically engineered bacteria. Nat. Biotechnol. 16:847-850.
7. Newburg, D. S. 1997. Do the binding properties of oligosaccharides in milk protect human infants from gastrointestinal bacteria? J. Nutr. 127:980S-984S.
8. Paton, A. W., R. Morona, and J. C. Paton. 2000. A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nat. Med. 6:265-270.
9. Prieto, P. A., and K. M. Kleman-Leyer. Aug. 1999. Process for synthesizing oligosaccharides. U.S. patent 5,945,314.
10. Prieto, P. A. 2004. Modern biotechnolgy for the production of dairy products, p. 25-49 In J.-R. Nesser and J. B. German (ed.), Bioprocesses and biotechnology for functional foods and nutraceuticals. Marcel Dekker, Inc., New York, N.Y.
11. Roberts, J. A., K. Hardaway, B. Kaack, E. N. Fussell, and G. Baskin. 1984. Prevention of pyelonephritis by immunization with P-fimbriae. J. Urol. 131:602-607.
12. Roberts, J. A., B. Marklund, D. Ilver, D. Haslam, M. B. Kaack, G. Baskin, M. Louis, R. Möllby, J. Winberg, and S. Normark. 1994. The Gal(α1-4)Gal-specific tip adhesin of Escherichia coli P-fimbriae is needed for pyelonephritis to occur in the normal urinary tract. Proc. Natl. Acad. Sci. USA 91:11889-11893.
13. Sandberg, T., B. Kaijser, G. Lidin-Janson, K. Lincoln, F. Orskov, I. Orskov, E., Stokland, and C. Svanborg-Eden. 1988. Virulence of Escherichia coli in relation to host factors in women with symptomatic urinary tract infection. J. Clin. Microbiol. 26:1471-1476.
14. Sharon, N., and I. Ofek. 2000. Safe as mother's milk: carbohydrates as future anti-adhesion drugs for bacterial diseases. Glycoconj. J. 17:659-664.
15. Sharon, N., and H. Lis. 1993. Carbohydrates in cell recognition. Sci. Am. 268:82-89.
16. Stromberg, N., B. I. Marklund, B. Lund, D. Ilver, A. Hamers, W. Gaastra, K. A., Karlsson, and S. Normark. 1990. Host-specificity of uropathogenic Escherichia coli depends on differences in binding specificity to Gal alpha 1-4Gal-containing isoreceptors. EMBO J. 9:2001-2010.
17. Svanborg-Eden, C., R. Freter, L., Hagberg R. Hull, S. Hull, H. Leffler, and G. Schoolnik. 1982. Inhibition of experimental ascending urinary tract infection by an epithelial cell-surface receptor analogue. Nature 298:560-562.
18. Warren, J. W. 1996. Virulence determinants of uropathogenic Escherichia coli, p. 135-174. In H. L. Mobley and J. W. Warren (ed.), Urinary tract infections: molecular pathogenesis and clinical management. ASM Press, Washington, D.C.