Structure and morphology of the Alzheimer's amyloid fibril

Microscopy Research and Technique

Volumn 67, Issue 3-4, 2005, Pages 210-217

  Stromer, Thusnelda ^a   Serpell, Louise C ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Alzheimer's disease; Amyloid; Cross structure; Fiber diffraction; Protofilament

Indexed keywords

AGGREGATES; DIFFRACTION; ELECTRON MICROSCOPES; ELECTRON MICROSCOPY; GLYCOPROTEINS; IMAGE ENHANCEMENT; NEURODEGENERATIVE DISEASES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

ALZHEIMER AMYLOID; ALZHEIMERS DISEASE; AMYLOID; AMYLOID FIBRIL; CROSS-Β STRUCTURE; FIBER DIFFRACTION; PROTOFILAMENTS; SPONGIFORM ENCEPHALOPATHIES; STRUCTURE AND MORPHOLOGY; TYPE-2 DIABETES;

ELECTRONS;

AMYLOID;

ALZHEIMER DISEASE; BETA SHEET; ELECTRON MICROSCOPY; HUMAN; IMAGE ANALYSIS; IMAGE ENHANCEMENT; IMAGE PROCESSING; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; REVIEW; SOLID STATE; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

EID: 24144438172     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.20190     Document Type: Review

References (43)

1. Antzutkin ON, Leapman RD, Balbach JJ, Tycko R. 2002. Supramolecular structural constraints on Alzheimer's β-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance. Biochemistry 41:15436-15450.
2. Benzinger TLS, Gregory DM, Burkoth TS, Miller-Auer H, Lynn DG, Botto RE, Meredith SC. 2000. Two-dimensional structure of β-amyloid(10-35) fibrils. Biochemistry 39:3491-3499.
3. Blackley HKL, Patel N, Davies MC, Roberts CJ, Tendler SJB, Wilkinson MJ, Williams PM. 1999. Morphological development of β(1-40) amyloid fibrils. Exp Neurol 158:437-443.
4. Chamberlain AK, MacPhee CE, Zurdo J, Morozova-Roche LA, Hill HAO, Dobson CM, Davis JJ. 2000. Ultrastructural organization of amyloid fibrils by atomic force microscopy. Biophys J 79:3282-3293.
5. Choo L, Wetzel D, Halliday W, Jackson M, LeVine S, Mantsch H. 1996. In situ characterization of β-amyloid in Alzheimer's disease tissue by synchrotron fourier transform infrared microspectroscopy. Biophys J 71:1672-1679.
6. Clark A, Cooper G, Lewis C, Morris J, Willis A, Reid K, Turner R. 1987. Islet amyloid formed from diabetes associated peptide may be pathogenic in type-2 diabetes. Lancet 2:231-234.
7. Cohen AS, Calkins E. 1959. Electron microscopic observation on a fibrous component in amyloid of diverse origins. Nature 183:1202-1203.
8. Cooper G, Day A, Willis A, Roberts A, Reid K, Leighton B. 1989. Amylin and the amylin gene: structure function and relationship to islet amyloid and diabetes mellitus. Biochim Biophys Acta 1014:247-258.
9. Eanes ED, Glenner GG. 1968. X-ray diffraction studies on amyloid filaments. J Histochem Cytochem 16:673-677.
10. Goldsbury CS, Cooper GJS, Goldie KN, Muller SA, Saafi EL, Gruijters WTM, Misur MP. 1997. Polymorphic fibrillar assembly of human amylin. J Struct Biol 119:17-27.
11. Goldsbury C, Kistler J, Aebi U, Arvinte T, Cooper G. 1998. Watching amyloid fibrils grow by atomic force microscopy (AFM). Mol Biol Cell 9:2640.
12. Goldsbury C, Kistler J, Aebi U, Arvinte T, Cooper G. 1999. Watching amyloid fibrils grow by time-lapse atomic force microscopy. J Mol Biol 285:33-39.
13. Goldsbury CS, Wirtz S, Muller SA, Sunderji S, Wicki P, Aebi U, Frey P. 2000. Studies on the in vitro assembly of Aβ1-40: implications for the search for Abeta fibril formation inhibitors. J Struct Biol 130: 217-231.
14. Green J, Goldsbury C, Mini T, Sunderji S, Frey P, Kistler J, Cooper G, Aebi U. 2003. Full-length rat amylin forms fibrils following substitution of single residues from human amylin. J Mol Biol 326:1147-1156.
15. Harper J, Wong S, Lieber C, Lansbury P. 1997. Observation of metastable Aβ amyloid protofibrils by atomic force microscopy. Chem Biol 6:119-125.
16. Harris JR. 2002. In vitro fibrillogenesis of the amyloid β1-42 peptide: cholesterol potentiation and aspirin inhibition. Micron 33:609-626.
17. Inouye H, Fraser P, Kirschner D. 1993. Structure of β-crystallite assemblies by Alzheimer β amyloid protein analogues: analysis by x-ray diffraction. Biophys J 64:502-519.
18. Jimenez JL, Guijarro JI, Orlova E, Zurdo J, Dobson C, Sunde M, Saibil H. 1999. Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing. EMBO J 18: 815-821.
19. Jimenez JL, Tennent G, Pepys MB, Saibil HR. 2001. Structural diversity of ex vivo amyloid fibrils studied by cryo-electron microscopy. J Mol Biol 311:241-247.
20. Jimenez JL, Nettleton EJ, Bouchard M, Robinson CV, Dobson CM, Saibil HR. 2002. The protofilament structure of insulin amyloid fibrils. Proc Natl Acad Sci U S A 99:9196-9201.
21. Kirschner D, Abraham C, Selkoe D. 1986. X-ray diffraction from intraneuronal paired helical filaments and extra-neuronal amyloid fibers in Alzheimers disease indicates cross β conformation. Proc Natl Acad Sci U S A 83:503-507.
22. Kirschner DA, Inouye H, Duffy LK, Sinclair A, Lind M, Selkoe DJ. 1987. Synthetic peptide homologous to β-protein from Alzheimer's disease forms amyloid-like fibrils in vitro. Proc Natl Acad Sci U S A 84:6953-6957.
23. Makin OS, Serpell LC. 2004. Structural characterisation of islet amyloid polypeptide fibrils. J Mol Biol 335:1279-1288.
24. Malinchik S, Inouye H, Szumowski K, Kirschner D. 1998. Structural analysis of Alzheimer's β(1-40) amyloid: protofilament assembly of tubular fibrils. Biophys J 74:537-545.
25. Nichols MR, Moss MA, Reed DK, Lin WL, Mukhopadhyay R, Hoh JH, Rosenberry TL. 2002. Growth of β(1-40) protofibrils by monomer elongation and lateral association. Characterization of distinct products by light scattering and atomic force microscopy. Biochemistry 41:6115-6127.
26. Petkova AT, Ishii Y, Balbach JJ, Antzutkin ON, Leapman RD, Delaglio F, Tycko R. 2002. A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR. Proc Natl Acad Sci U S A 99:16742-16747.
27. Petkova AT, Buntkowsky G, Dyda F, Leapman RD, Yau WM, Tycko R. 2004. Solid state NMR reveals a pH-dependent antiparallel beta-sheet registry in fibrils formed by a β-amyloid peptide. J Mol Biol 335:247-260.
28. Puchtler H, Sweat F, Levine M. 1961. On the binding of Congo red by amyloid. J Histochem Cytochem 10:355-364.
29. Selkoe DJ. 1991. The molecular pathology of Alzheimer's disease. Neuron 6:487-498.
30. Serpell L. 2000. Alzheimer's amyloid fibrils: structure and assembly. Biochim Biophys Acta 1502:16-30.
31. Serpell L, Smith J. 2000. Direct visualisation of the β-sheet structure of synthetic Alzheimer's amyloid. J Mol Biol 299:225-231.
32. Serpell LC, Sunde M, Fraser PE, Luther PK, Morris E, Sandgren O, Lundgren E, Blake CCF. 1995. The examination of the structure of the transthyretin amyloid fibril by image reconstruction from electron micrographs. J Mol Biol 254:113-118.
33. Serpell L, Sunde M, Benson M, Tennent G, Pepys M, Fraser P. 2000. The protofilament substructure of amyloid fibrils. J Mol Biol 300:1033-1039.
34. Shirahama T, Cohen AS. 1967. High resolution electron microscopic analysis of the amyloid fibril. J Cell Biol 33:679-706.
35. Sikorski P, Atkins EDT, Serpell LC. 2003. Structure and textures of fibrous crystals of the Aβ(11-25) fragment from Alzheimer's Aβ-amyloid protein. Structure 11:915-926.
36. Sipe JD. 1992. Amyloidosis. Annu Rev Biochem 61:947-975.
37. Stine W, Snyder S, Ladror U, Wade W, Miller M, Perun T, Holzman T, Krafft G. 1996. The nanometer-scale structure of amyloid-β visualized by atomic force microscopy. J Prot Chem 15: 193-203.
38. Sunde M, Blake C. 1998. From the globular to the fibrous state: protein structure and structural conversion in amyloid formation. Q Rev Biophys 31:1-39.
39. Sunde M, Serpell L, Bartlam M, Fraser P, Pepys M, Blake C. 1997. Common core structure of amyloid fibrils by synchrotron X-ray diffraction. J Mol Biol 273:729-739.
40. Tycko R. 2003. Insights into the amyloid folding problem from solid-state NMR. Biochemistry 42:3151-3159.
41. Walsh D, Lomakin A, Benedek G, Condron M, Teplow D. 1997. Amyloid β-protein fibrillogenesis. J Biol Chem 272:22364-22372.
42. Wolfe MS. 2003. The secretases of Alzheimer's disease. Curr Top Dev Biol 54:233-261.
43. Wood SJ, Maleeff B, Hart T, Wetzel R. 1996. Physical, morphological and functional differences between pH 5.8 and 7.4 aggregates of the Alzheimer's amyloid peptide Aβ. J Mol Biol 256:870-877.