A liquid chromatographic-tandem mass spectrometric method for the determination of two selective thymidylate synthase inhibitors, BGC945 and BGC638, in mouse plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 824, Issue 1-2, 2005, Pages 181-188

  Wood, Nadya ^a   Gibbs, David D ^a   Jackman, Ann L ^a   Henley, Alan ^a   Workman, Paul ^a   Raynaud, Florence ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

BGC638; BGC945; Liquid chromatography tandem mass spectrometry; Validation

Indexed keywords

ACETONITRILE; BIOASSAY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMAS; PRECIPITATION (CHEMICAL); PROTEINS; QUALITY CONTROL;

BGC638; BGC945; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; VALIDATION;

ENZYMES;

ACETONITRILE; BGC 638; BGC 945; PROTEIN; QUINAZOLINE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DETERMINATION; FLOW RATE; HALF LIFE TIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PLASMA; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; SAMPLE; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, LIQUID; ENZYME INHIBITORS; HUMANS; INJECTIONS, INTRAVENOUS; KB CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; QUINAZOLINES; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THYMIDYLATE SYNTHASE;

EID: 24044552007     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.07.025     Document Type: Article

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