Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast

Aquatic Toxicology

Volumn 74, Issue 4, 2005, Pages 294-306

  Selheim, Frode ^a   Herfindal, Lars ^a   Martins, Rosario ^b,c   Vasconcelos, Vitor ^b,c   Døskeland, Stein Ove ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b UNIVERSITY OF PORTO   (Portugal)

^c Departamento de Zoologia e Antropologia   (Portugal)

Author keywords

Aphanothece sp.; Benthic cyanobacteria; Blood platelets; Neuroblastoma; Toxic cyanobacteria

Indexed keywords

BACTERIAL TOXIN; PADGEM PROTEIN; PHOSPHOTYROSINE; THROMBIN;

APOPTOSIS; CYANOBACTERIUM; TOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTERIUM ISOLATION; BENTHOS; BLEEDING; CELL SURFACE; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; CYANOBACTERIUM; FIBROBLAST; GENUS; HUMAN; HUMAN CELL; INHIBITION KINETICS; KIDNEY CELL; LETHALITY; LETHARGY; LIVER CELL; MALE; MARINE ENVIRONMENT; MICROBIAL ACTIVITY; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PORTUGAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEASHORE; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; TOXICITY;

ANIMALS; APOPTOSIS; ATLANTIC OCEAN; BACTERIAL TOXINS; BIOLOGICAL ASSAY; CELL EXTRACTS; CELLS, CULTURED; CYANOBACTERIA; MARINE TOXINS; MICE; PLATELET ACTIVATION; PORTUGAL; SPECIES SPECIFICITY;

EASTERN HEMISPHERE; EURASIA; EUROPE; PORTUGAL; SOUTHERN EUROPE; WORLD;

APHANOTHECE; APHANOTHECE SP.; CYANOBACTERIA; MAMMALIA;

EID: 24044549646     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquatox.2005.06.005     Document Type: Article

References (44)

1. C. Ananth, S. Thameem Dheen, P. Gopalakrishnakone, and C. Kaur Domoic acid-induced neuronal damage in the rat hippocampus: changes in apoptosis related genes (bcl-2, bax, caspase-3) and microglial response J. Neurosci. Res. 66 2001 177 190
2. S. Antonopoulou, A. Oikonomou, H.C. Karantonis, E. Fragopoulou, and A. Pantazidou Isolation and structural elucidation of biologically active phospholipids from Scytonema julianum (cyanobacteria) Biochem. J. 367 2002 287 293
3. G.W. Chacko, J.T. Brandt, K.M. Coggeshall, and C.L. Anderson Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides J. Biol. Chem. 271 1996 10775 10781
4. E.A. Clark, S.J. Shattil, M.H. Ginsberg, J. Bolen, and J.S. Brugge Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3 J. Biol. Chem. 269 1994 28859 28864
5. J.E. Ferrell Jr., and G.S. Martin Platelet tyrosine-specific protein phosphorylation is regulated by thrombin Mol. Cell Biol. 8 1988 3603 3610
6. K.E. Fladmark, O.T. Brustugun, R. Hovland, R. Boe, B.T. Gjertsen, B. Zhivotovsky, and S.O. Døskeland Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors Cell Death Differ. 6 1999 1099 1108
7. 2+/calmodulin- dependent protein kinase II is required for microcystin-induced apoptosis J. Biol. Chem. 277 2002 2804 2811
8. K.E. Fladmark, M.H. Serres, N.L. Larsen, T. Yasumoto, T. Aune, and S.O. Døskeland Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes Toxicon 36 1998 1101 1114
9. S.M. Froscio, A.R. Humpage, P.C. Burcham, and I.R. Falconer Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes Environ. Toxicol. 18 2003 243 251
10. J. Geiger Inhibitors of platelet signal transduction as anti-aggregatory drugs Expert Opin. Investig. Drugs 10 2001 865 890
11. A. Golden, and J.S. Brugge Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets Proc. Natl. Acad. Sci. U.S.A. 86 1989 901 905
12. G.G. Harrigan, W.Y. Yoshida, R.E. Moore, D.G. Nagle, P.U. Park, J. Biggs, V.J. Paul, S.L. Mooberry, T.H. Corbett, and F.A. Valeriote Isolation, structure determination, and biological activity of dolastatin 12 and lyngbyastatin 1 from Lyngbya majuscula/Schizothrix calcicola cyanobacterial assemblages J. Nat. Prod. 61 1998 1221 1225
13. H. Holmsen Platelet secretion and energy metabolism R.W. Colman J. Hirsh V. Marder E.W. Salzman Platelet secretion and energy metabolism 1993 Lippincott Philadelphia pp. 524-545
14. S. Hsu-Lin, C.L. Berman, B.C. Furie, D. August, and B. Furie A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets J. Biol. Chem. 259 1984 9121 9126
15. M.-M. Huang, Z. Indik, L.F. Brass, J.A. Hoxie, A.D. Schreiber, and J.S. Brugge Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII J. Biol. Chem. 267 1992 5467 5473
16. B.O. Jensen, F. Selheim, S.O. Døskeland, A.R.L. Gear, and H. Holmsen Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide Blood 104 2004 2775 2782
17. P.V. Lakshmana Rao, R. Bhattacharya, N. Gupta, M.M. Parida, A.S. Bhaskar, and R. Dubey Involvement of caspase and reactive oxygen species in cyanobacterial toxin anatoxin-a-induced cytotoxicity and apoptosis in rat thymocytes and Vero cells Arch. Toxicol. 76 2002 227 235
18. R.J. Ludwig, J.E. Schultz, W.-H. Boehncke, M. Podda, C. Tandi, F. Krombach, H. Baatz, R. Kaufmann, U.H. von Andrian, and T.M. Zollner Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules J. Invest. Dermatol. 122 2004 830 836
19. C. MacKintosh, K.A. Beattie, S. Klumpp, P. Cohen, and G.A. Codd Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants FEBS Lett. 264 1990 187 192
20. P.B. Maguire, K.J. Wynne, D.F. Harney, N.M. O'Donoghue, G. Stephens, and D.J. Fitzgerald Identification of the phosphotyrosine proteome from thrombin activated platelets Proteomics 2 2002 642 648
21. G. Mellgren, O.K. Vintermyr, and S.O. Døskeland Okadaic acid, cAMP, and selected nutrients inhibit hepatocyte proliferation at different stages in G1: modulation of the cAMP effect by phosphatase inhibitors and nutrients J. Cell Physiol. 163 1995 232 240
22. M. Merten, T. Chow, J.D. Hellums, and P. Thiagarajan A new role for P-selectin in shear-induced platelet aggregation Circulation 102 2000 2045 2050
23. J.J. Michiels, Z.N. Berneman, W. Schroyens, and H.H.M. Van Vliet Pathophysiology and treatment of platelet-mediated microvascular disturbances, major thrombosis and bleeding complications in essential thrombocythaemia and polycythaemia vera Platelets 15 2004 67 84
24. 2 in porcine platelets and phosphorylates GTPase activating protein on tyrosine residue(s) J. Biochem. 116 1994 1176 1181
25. S. Nakamura, and H. Yamamura Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets J. Biol. Chem. 264 1989 7089 7091
26. W. Nicklas, P. Baneux, R. Boot, T. Decelle, A.A. Deeny, M. Fumanelli, and B. Illgen-Wilcke Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units Lab. Anim. 36 2002 20 42
27. K. Prabhakaran, D.A. Sampson, and J.C. Hoehner Neuroblastoma survival and death: an in vitro model of hypoxia and metabolic stress J. Surg. Res. 116 2004 288 296
28. S.P. Presgraves, T. Ahmed, S. Borwege, and J.N. Joyce Terminally differentiated SH-SY5Y cells provide a model system for studying neuroprotective effects of dopamine agonists Neurotox. Res. 5 2004 579 598
29. G. Radau, J. Gebel, and D. Rauh New cyanopeptide-derived low molecular weight thrombin inhibitors Arch. Pharm. (Weinheim) 336 2003 372 380
30. M.T. Runnegar, I.R. Falconer, T. Buckley, and A.R. Jackson Lethal potency and tissue distribution of 125I-labelled toxic peptides from the blue-green alga Microcystis aeruginosa Toxicon 24 1986 506 509
31. M.T. Runnegar, S.-M. Kong, Y.-Z. Zhong, and S.C. Lu Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes Biochem. Pharmacol. 49 1995 219 225
32. A. Ryningen, and H. Holmsen Thrombin per se does not induce tyrosine protein phosphorylation in human platelets as judged by western blotting, while collagen does: the significance of synergistic, autocrine stimulation Biochem. Biophys. Res. Commun. 245 1998 757 763
33. T. Sandal, L. Aumo, L. Hedin, B.T. Gjertsen, and S.O. Døskeland Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis Mol. Biol. Cell 14 2003 3292 3304
34. F. Selheim, M.H. Fukami, H. Holmsen, and F.S. Vassbotn Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activation Biochem. J. 350 2000 469 475
35. F. Selheim, H. Holmsen, and F.S. Vassbotn Platelet-derived growth factor inhibits platelet activation in heparinized whole blood Thromb. Res. 95 1999 185 196
36. M.H. Serres, K.E. Fladmark, and S.O. Døskeland An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases Toxicon 38 2000 347 360
37. S.J. Shattil, and P.J. Newman Integrins: dynamic scaffolds for adhesion and signaling in platelets Blood 104 2004 1606 1615
38. K. Sivonen, and G. Jones Cyanobacterial toxins I. Chorus J. Bartram Cyanobacterial toxins 1999 E & FN Spon London pp. 41-111
39. 2+ mobilization in platelets J. Biol. Chem. 268 1993 2277 2279
40. D.M. Toivola, J.E. Eriksson, and D.L. Brautigan Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates FEBS Lett. 344 1994 175 180
41. K. Whittle, and S. Gallacher Marine toxins Br. Med. Bull. 56 2000 236 253
42. C. Wiegand, and S. Pflugmacher Ecotoxicological effects of selected cyanobacterial secondary metabolites: a short review Toxicol. Appl. Pharmacol. 203 2005 201 218
43. S. Yanagi, K. Sada, Y. Tohyama, M. Tsubokawa, K. Nagai, K. Yonezawa, and H. Yamamura Translocation, activation and association of protein-tyrosine kinase (p72syk) with phosphatidylinositol 3-kinase are early events during platelet activation Eur. J. Biochem. 224 1994 329 333
44. S. Zolnierowicz Type 2A protein phosphatase, the complex regulator of numerous signaling pathways Biochem. Pharmacol. 60 2000 1225 1235