Molecular detection of EWS-Ets fusion transcripts and their clinicopathologic significance in Ewing's sarcoma/peripheral primative neuroectodermal tumor

Chinese Medical Journal

Volumn 118, Issue 16, 2005, Pages 1323-1329

  Wang, Hua ^a   Zheng, Jie ^a   Wang, Yu Ping ^a   Yang, Yu ^a   You, Jiang Feng ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Ewing's sarcoma peripheral primitive neuroectodermal tumor; Gene fusion; Reverse transcriptase polymerase chain reaction

Indexed keywords

BETA 2 MICROGLOBULIN; BETA ACTIN; CD99 ANTIGEN; HYBRID PROTEIN; MOLECULAR MARKER; PARAFFIN; RNA BINDING PROTEIN EWS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR FLI1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; CHILD; CHIMERA; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DESMOPLASTIC SMALL ROUND CELL TUMOR; DIAGNOSTIC PROCEDURE; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; EWING SARCOMA; EXON; FEASIBILITY STUDY; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFORMATION PROCESSING; LYMPHOMA; MALE; NEUROBLASTOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; SMALL CELL CARCINOMA;

ADOLESCENT; ADULT; CHILD; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL; ONCOGENE PROTEINS, FUSION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEIN C-FLI-1; RNA, MESSENGER; SARCOMA, EWING'S; TRANSCRIPTION FACTORS;

EID: 24044538524     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Weiss SW, Goldblum JR. Primitive Neuroectodermal Tumors and Related Lesions. In: Enzinger and Weiss' s Soft tissue tumors, 4th ed. St. Louis: Mosby-Year Book; 2002:1265-1321.
2. Aurias A, Rimbaut C, Buffe D, et al. Chromosomal translocations in Ewing's sarcoma. N Engl J Med 1983;309:496-497.
3. Delattre O, Zucman J, Melot T, et al. The Ewing family of tumors-a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 1994;331:294-299.
4. Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992;359:162-165.
5. Zucman J, Melot T, Desmaze C, et al. Combinatorial generation of variable fusion proteins in the Ewing family of tumours. EMBO J 1993;12:4481-4487:
6. Sorensen PH, Lessnick SL, Lopez-Terrada D, et al. A second Ewing' s sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 1994;6:146-151.
7. Argani P, Zakowski MF, Klimstra DS, et al. Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic cases. Mod Pathol 1998;11:65-71.
8. Ambros IM, Ambros PF, Strehl S, et al. MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 1991;67:1886-1893.
9. Devoe K, Weidner N. Immunohistochemistry of small round-cell tumors. Semin Diagn Pathol 2000;17:216-224.
10. Ladanyi M, Lewis R, Garin-Chesa P, et al. EWS rearrangement in Ewing's sarcoma and peripheral neuroectodermal tumor. Molecular detection and correlation with cytogenetic analysis and MIC2 expression. Diagn Mol Pathol 1993;2:141-146.
11. Jeon IS, Davis JN, Braun BS, et al. A variant Ewing' s sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene 1995;10:1229-1234.
12. Urano F, Umezawa A, Hong W, et al. A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma. Biochem Biophys Res Commun 1996;219:608-612.
13. Peter M, Couturier J, Pacquement H, et al. A new member of the ETS family fused to EWS in Ewing tumors. Oncogene 1997;14:1159-1164.
14. Sreekantaiah C, Ladanyi M, Rodriguez E, et al. Chromosomal aberrations in soft tissue tumors. Relevance to diagnosis, classification, and molecular mechanisms. Am J Pathol 1994;144:1121-1134.
15. Adams V, Hany MA, Schmid M, et al. Detection of t(11;22) (q24;q12) translocation breakpoint in paraffin-embedded tissue of the Ewing's sarcoma family by nested reverse transcription-polymerase chain reaction. Diagn Mol Pathol 1996;5:107-113.
16. O'Sullivan MJ, Perlman EJ, Furman J, et al. Visceral primitive peripheral neuroectodermal tumors: a clinicopathologic and molecular study. Hum Pathol 2001;32:1109-1115.
17. de Alava E, Kawai A, Healey JH, et al. EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma. J Clin Oncol 1998; 16:1248-1255.
18. Bailly RA, Bosselut R, Zucman J, et al. DNA-binding and transcriptional activation properties of the EWS-FLI1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol Cell Biol 1994;14:3230-3241.
19. Zoubek A, Dockhorn-Dworniczak B, Delattre O, et al. Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients? J Clin Oncol 1996;14:1245-1251.
20. Lin PP, Brody RI, Hamelin AC, et al. Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma. Cancer Res 1999;59:1428-1432.
21. de Alava, E, Panizo A, Antonescu CR, et al. Association of EWS-FLI1 type 1 fusion with lower proliferative rate in Ewing's sarcoma. Am J Pathol 2000;156:849-855.
22. Aryee DN, Sommergruber W, Muehlbacher K, et al. Variability in gene expression patterns of Ewing tumor cell lines differing in EWS-FLI1 fusion type. Lab Invest 2000;80:1833-1844.