Melanocytic nevi are associated with neurofibromas in neurofibromatosis, type I, but not sporadic neurofibromas. A study of 226 cases

Journal of Cutaneous Pathology

Volumn 32, Issue 8, 2005, Pages 523-532

  Ball, Nigel J ^a,c   Kho, Grace T ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ROYAL JUBILEE HOSPITAL   (Canada)

^c VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

KERATIN;

ADULT; AGED; CANADA; CASE CONTROL STUDY; CELL HYPERPLASIA; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; ELASTOSIS; FEMALE; FOLLICULITIS; GRANULOMA; HISTOLOGY; HUMAN; HUMAN TISSUE; HYPERPLASIA; LIPOMA; MAJOR CLINICAL STUDY; MALE; MELANOCYTE; MELANOCYTIC NEVUS; MELANOSOME; NEUROFIBROMA; NEUROFIBROMATOSIS; RETROSPECTIVE STUDY; SEBACEOUS GLAND; SKIN PIGMENTATION;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CELL PROLIFERATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; MALE; MELANOCYTES; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; NEUROFIBROMA; NEUROFIBROMATOSIS 1; NEVUS, PIGMENTED; RETROSPECTIVE STUDIES; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 24044482915     PISSN: 03036987     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0303-6987.2005.00376.x     Document Type: Conference Paper

References (62)

1. National Institutes of Health Consensus Development Conference. Neurofibromatosis: conference statement. Arch Neurol 1988; 45: 575.
2. Riccardi VM. The pathophysiology of neurofibromatosis. IV. Dermatologic insights in to heterogeneity and pathogenesis. J Am Acad Dermatol 1980; 3: 157.
3. Mar WA, Bangert J, Hansen RC. Enlarging congenital pigmented plaque. Unusual, continuous, plaque-type neurofibroma in segmental neurofibromatosis simulating a giant congenital nevus. Arch Dermatol 2004; 140: 751.
4. Crowe FW, Schull WJ, Neel JV. A Clinical, Pathological, and Genetic Study of Multiple Neurofibromatosis. Springfield, IL: Charles C. Thomas, 1956; 181.
5. Mastrangelo MF, Goepp CE, Patel YA, Clark WH Jr. Cutaneous melanoma in a patient with neurofibromatosis. Arch Dermatol 1979; 115: 864.
6. Johnson BL, Charneco DR. Café au lait spot in neurofibromatosis and in normal individuals. Arch Dermatol 1970; 102: 442.
7. Xu GF, O'Connell P, Viskochil D, et al. The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell 1990; 62: 599.
8. Pollock PM, Harper UL, Hansen KS, et al. High frequency of BRAF mutations in nevi. Nat Genet 2003; 33: 19.
9. Ball NF, Yohn JJ, Morelli JG, Norris DA, Golitz LE, Hoeffler JP. Ras mutations in human melanoma: a marker of malignant progression. J Invest Dermatol 1994; 102: 285.
10. Val-Bernal JF, Dehesa J, Garijo MF, Val D. Cutaneous lipomatous neurofibroma. Am J Dermatopathol 2002; 24: 246.
11. Ahn SK, Ahn HJ, Kim TH, Hwang SM, Choi EH, Lee SH. Intratumoral fat in neurofibroma. Am J Dermatopathol 2002; 24: 326.
12. Petronic-Rosic V, Shea CR. Lipomatous neurofibroma - a report of three cases. Am J Dermatopathol 2004; 26: 137 [Abstract].
13. Conlin PA, Jimenez-Quintero LP, Rapini RP. Osteomas of the skin revisited. A cliniclpathologic review of 74 cases. Am J Dermatopathol 2002; 24: 479.
14. Del Rio E, Yus ES, Simon P, Veiga HAV. Stimulation of folliculo-sebaceous proliferations by neurofibromas: a report of two cases. J Cutan Pathol 1998; 25: 228.
15. Eng W, Cohen PR. Nevus with fat: clinical characteristics of 100 nevi containing mature adipose cells. J Am Acad Dermatol 1998; 39: 704.
16. Weedon D. Unusual features of nevocellular nevi. J Cutan Pathol 1982; 9: 284.
17. Mehregan AH, Staricco RG. Elastic fibers in pigmented nevi. J Invest Dermatol 1962; 38: 271.
18. Cohen PR, Rapini RP. Nevus with cyst. A report of 93 cases. Am J Dermatopathol 1993; 15: 229.
19. Knox WF, McWilliam LJ, Benbow EW, McMahon RFT, Wilkinson N, Bonshek R. Foreign body giant cell reactions and ossification associated with benign melanocytic naevi. J Clin Pathol 1993; 46: 72.
20. Hutcheson ACS, Nietert PJ, Maize JC. Incidental epidermolytic hyperkeratosis and focal acantholytic dyskeratosis in common acquired melanocytic nevi and atypical melanocytic lesions. J Am Acad Dermatol 2004; 50: 388.
21. Fallowfield ME, Curley RK, Cook MG. Melanocytic lesions and melanocytic populations in human epidermis. Br J Dermatol 1991; 124: 130.
22. Jimbow K, Horikoshi T. The nature and significance of macromelanosomes in pigmented skin lesions. Their morphological characteristics, specificity for their occurrence, and possible mechanisms for their formation. Am J Dermatopathol 1982; 4: 413 [review].
23. Requena L, Sangüeza OP. Benign neoplasms with neural differentiation: a review. Am J Dermatopathol 1995; 17: 75 [review].
24. Requena L, Yus ES, Pilar S, del Rio E. Induction of cutaneous hyperplasias by altered stroma. Am J Dermatopathol 1996; 18: 248.
25. Carr NJ, Warren AY. Mast cell numbers in melanocytic naevi and cutaneous neurofibromas. J Clin Pathol 1993; 46: 86.
26. Gray MH, Smoller BR, McNutt NS, Hsu A. Neurofibromas and neurotized melanocytic nevi are immunohistochemically distinct neoplasms. Am J Dermatopathol 1990; 12: 234.
27. Kroumpouzos G, Cohen LM. Intradermal melanocytic nevus with prominent Schwannian differentiation. Am J Dermatopathol 2002; 24: 39.
28. Misago N. The relationship between melanocytes and peripheral nerve sheath cells (part I): melanocytic nevus (excluding so-called 'blue nevus') with peripheral nerve sheath differentiation. Am J Dermatopathol 2000; 22: 217.
29. Pennys NS, Mogollon R, Kowalczyk A, Nadji M, Adachi K. A survey of cutaneous neural lesions for the presence of myelin basic protein. An immunohistochemical study. Arch Dermatol 1984; 120: 210.
30. Maize JC Jr, Resneck JS Jr, Shapiro PE, McCalmont TH, LeBoit PE. Ducking stray 'magic bullets': a Melan-A alert. Am J Dermatopathol 2003; 25: 162.
31. El Shabrawi-Caelen L, Kerl H, Cerroni L. Melan-A: not a helpful marker in distinction between melanoma in situ on sun damaged skin and pigmented actinic keratosis. Am J Dermatopathol 2004; 26: 364.
32. Boyd AS, Rapini RP. Cutaneous collision tumors. An analysis of 69 cases and review of the literature. Am J Dermatopathol 1994; 16: 253.
33. Williamson TH, Garner A, Moore AT. Structure of Lisch nodules in neurofibromatosis type 1. Ophthalmal Paediatr Genet 1991; 12: 11.
34. Karvonen SL, Kallioinen M, Ylä-Outinen H, Pöyhönen M, Oikarinen A, Peltonen J. Occult neurofibroma and increased S100 protein in the skin of patients with neurofibromatosis type 1. New insights to the etiopathomechanism of neurofibromas. Arch Dermatol 2000; 136: 1207.
35. Jimbow K, Quevedo WC Jr, Fitzpatrick TB, Szabo G. Some aspects of melanin biology. J Invest Dermatol 1976; 67: 72 [review].
36. Okamura JM, Barr RJ, Cantos KA. Benign atypical melanocytic hyperplasia associated with intradermal nevi: a common finding that may be confused with melanoma in situ. Mod Pathol 2000; 13: 857.
37. Zimarowski MJ, Harrist TJ, Crowson CM, Clark WH. Atypical melanocytic hyperplasia in fibrous papules mimicking lentigo maligna. Mod Pathol 1994; 7: 51A [Abstract].
38. Florell SR, Boucher KM, Leachman SA, et al. Histopathologic recognition of involved margins of lentigo maligna excised by staged excision. An interobserver comparison study. Arch Dermatol 2003; 139: 595.
39. Mitchell RE. The effect of prolonged solar radiation on melanocytes of the human epidermis. J Invest Dermatol 1963; 41: 199.
40. Rhodes AR, Harrist TJ, Momtaz TK. The PUVA-induced pigmented macule: a lentiginous proliferation of large, sometimes cytologically atypical, melanocytes. J Am Acad Dermatol 1984; 9: 47.
41. Peter RU, Gottlöber P, Nadeshina N, Krähn G, Plewig G, Kind P. Radiation lentigo: a distinct cutaneous lesion after accidental radiation exposure. Arch Dermatol 1997; 133: 209.
42. Tosti A, Piraccini BM, Misciali C, Vincenzi C. Lentiginous eruption due to topical immunotherapy. Arch Dermatol 2003; 139: 544 (letter).
43. Botella-Estrada R, Sanmartin O, Sevila A, Escudero A, Guillén C. Melanotic pigmentation in excision scars of melanocytic and non-melanocytic skin tumors. J Cutan Pathol 1999; 26: 137.
44. Cheng L, Amini SB, Zaim T. Follicular basal cell hyperplasia overlying dermatofibroma. Am J Surg Pathol 1997; 21: 711.
45. Barr RJ, Goodman MM. Neurofollicular hamartoma: a light microscopic and immunohistochemical study. J Cutan Pathol 1989; 16: 336.
46. Weyers W, Bonczkowitz M, Weyers I, Bittinger A, Schill WB. Melanoma in situ versus melanocytic hyperplasia in sun-damaged skin: assessment of the significance of histopathologic criteria for differential diagnosis. Am J Dermatopathol 1996; 18: 560.
47. Riccardi VM. Of mass and men: neurofibromas and histogenesis. Arch Dermatol 2000; 136: 1257 [comment].
48. Maitra A, Gazdar AF, Moore TO, Moore AY. Loss of heterozygosity analysis of cutaneous melanoma and benign melanocytic nevi: laser capture microdissection demonstrates clonal genetic changes in acquired nevocellular nevi. Hum Pathol 2002; 33: 191.
49. Hui P, Perkins AS, Glusac EJ. Assessment of clonality in melanocytic nevi. J Cutan Pathol 2001; 28: 140.
50. Ackerman AB, Ragaz A. The lives of lesions: Chronology in Dermatology. New York: Masson Publishing USA, 1984; 203.
51. Trejo O, Reed JA, Prieto VG. Atypical cells in human cutaneous re-excision scars for melanoma express p75NGFR, C56/N-CAM and GAP-43: evidence of early Schwann cell differentiation. J Cutan Pathol 2002; 29: 397.
52. Ward K, O'Connell P, Carey JC, et al. Diagnosis of neurofibromatosis I by using tightly linked, flanking DNA markers. Am J Hum Genet 1990; 46: 943.
53. Korf BR. Malignancy in neurofibromatosis type 1. Oncologist 2000; 5: 477 [review].
54. Slater C, Hayes MM, Saxe N, Temple-Camp C, Beighton P. Macromelanosomes in the early diagnosis of neurofibromatosis. Am J Dermatopathol 1986; 8: 284.
55. Kaufmann D, Wiandt S, Veser J, Krone W. Increased melanogenesis in cultured epidermal melanocytes from patients with neurofibromatosis 1 (NF 1). Hum Genet 1991; 87: 144.
56. Maize JC, Foster G. Age-relate changes in melanocytic nevi. Clin Exp Dermatol 1979; 4: 49.
57. Megahed M. Histopathological variants of neurofibroma. A study of 114 lesions. Am J Dermatopathol 1994; 16: 486.
58. Winkelmann RK, Rocha G. The dermal nevus and statistics. Arch Dermatol 1962; 86: 310.
59. Zwarthoff EC. Neurofibromatosis and associated tumour suppressor genes. Pathol Res Pract 1996; 192: 647 [review].
60. Horikoshi T, Jimbow K, Sugiyama S. Ultrastructural comparison of giant pigment granules (large melanosome complexes) with macromelanosomes in various cutaneous pigmented lesions. In Seiji M, ed. Pigment Cell. Tokyo: University of Tokyo Press, 1981; 313.
61. Freeman RG, Knox JM. Epidermal cysts associated with pigmented nevi. Arch Dermatol 1962; 85: 72.
62. Williams BT, Barr RJ. Epidermolytic hyperkeratosis in nevi. A possible marker for atypia. Am J Dermatopathol 1996; 18: 156.