Weight loss during pegylated interferon and ribavirin treatment of chronic hepatitis C

Journal of Viral Hepatitis

Volumn 12, Issue 5, 2005, Pages 531-535

  Seyam, M S ^a   Freshwater, D A ^a   O'Donnell, K ^a   Mutimer, David J ^a  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Hepatitis C virus; Pegylated interferon; Ribavirin; Weight loss

Indexed keywords

PEGINTERFERON; PEGINTERFERON ALPHA2B; RIBAVIRIN;

ADULT; AGE; AGED; ARTICLE; BODY WEIGHT; ETHNIC GROUP; FEMALE; GENDER; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SIDE EFFECT; TREATMENT OUTCOME; VIRUS GENE; WEIGHT REDUCTION;

ADULT; AGED; ANTIVIRAL AGENTS; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; HEALTH STATUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERONS; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS; RIBAVIRIN; WEIGHT LOSS;

EID: 24044471632     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2005.00637.x     Document Type: Article

References (20)

1. Fried MW. Side effects of therapy of hepatitis C and their management. Hepatology 2002; 36(5) (Suppl 1): S237-S244.
2. Schering Corporation. Package Information for PEG-Intron. Kenilworth, New Jersey: Schering Corporation, 2001.
3. Anonymous. Schering PEG-INTRON Phase IV trial to study African Americans. The Pink Sheet 2001; 63(16).
4. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358(9286): 958-965.
5. Fried MW, Shiffman ML, Reddy KR et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347(13): 975-982.
6. Heathcote EJ, Shiffman ML, Cooksley WG et al. Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis. N Engl J Med 2000; 343(23): 1673-1680.
7. Zeuzem S, Feinman SV, Rasenack J et al. Peginterferon alfa-2a in patients with chronic hepatitis C. N Engl J Med 2000; 343(23): 1666-1672.
8. Ishak K, Baptista A, Bianchi L et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22(6): 696-699.
9. Gottrand F, Michaud L, Guimber D et al. Influence of recombinant interferon alpha on nutritional status and growth pattern in children with chronic viral hepatitis. Eur J Pediatr 1996; 155(12): 1031-1034.
10. Cotler SJ, Reddy KR, McCone J et al. An analysis of acute changes in interleukin-6 levels after treatment of hepatitis C with consensus interferon. J Interferon Cytokine Res 2001; 21(12): 1011-1019.
11. Kallinowski B, Haseroth K, Marinos G et al. Induction of tumour necrosis factor (TNF) receptor type p55 and p75 in patients with chronic hepatitis C virus (HCV) infection. Clin Exp Immunol 1998; 111(2): 269-277.
12. Tilg H, Vogel W, Dinarello CA. Interferon-alpha induces circulating tumor necrosis factor receptor p55 in humans. Blood 1995; 85(2): 433-435.
13. Matarese G, La Cava A. The intricate interface between immune system and metabolism. Trends Immunol 2004; 25(4): 193-200.
14. Enjoji M, Nakamuta M, Iwao M et al. Leptin response in patients undergoing interferon therapy. J Clin Gastroenterol 2002; 34(3): 287-288.
15. Widjaja A, Wedemeyer H, Tillmann HL et al. Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy. Scand J Gastroenterol 2001; 36(4): 426-431.
16. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402(6762): 656-660.
17. Wren AM, Seal LJ, Cohen MA et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001; 86(12): 5992.
18. Wren AM, Small CJ, Abbott CR et al. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001; 50(11): 2540-2547.
19. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000; 407(6806): 908-913.
20. Nakazato M, Murakami N, Date Y et al. A role for ghrelin in the central regulation of feeding. Nature 2001; 409(6817): 194-198.