Aromatic L-amino acid decarboxylase turnover in vivo in rhesus macaque striatum: A microPET study

Brain Research

Volumn 1054, Issue 1, 2005, Pages 55-60

  DeJesus, O T ^a   Flores, L G ^a   Murali, D ^a   Converse, A K ^b   Bartlett, R M ^a   Barnhart, T E ^a   Oakes, T R ^b   Nickles, R J ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Aromatic L amino acid decarboxylase; MicroPET imaging; Parkinson's disease; Protein turnover

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE;

ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; ENZYME INHIBITION; MACACA; MALE; MOTOR PERFORMANCE; NEUROTRANSMISSION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ANIMALS; AROMATIC-L-AMINO-ACID DECARBOXYLASES; CORPUS STRIATUM; MACACA MULATTA; MAGNETIC RESONANCE IMAGING; MALE; POSITRON-EMISSION TOMOGRAPHY; TIME FACTORS; TYROSINE;

EID: 23944517275     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.06.086     Document Type: Article

References (30)

1. F.W. Alexander, E. Sandmeier, P.K. Mehta, and P. Christen Evolutionary relationships among pyridoxal-5′-phosphate-dependent enzymes. Regio-specific alpha, beta and gamma families Eur. J. Biochem. 219 1994 953 960
2. 11C]deprenyl J. Neurochem. 49 1987 522 527
3. P. Bey, J.P. Vevert, V. Van Dorsselaer, and M. Kolb Direct synthesis of α-halogenomethyl-α-amino acids from the parent α-amino acids J. Org. Chem. 44 1979 2732 2742
4. P. Bey, M.J. Jung, J. Koch-Weser, M.G. Palfreyman, A. Sjoerdsma, J. Wagner, and M. Zraika Further studies on the inhibition of monoamine synthesis by α-monofluoromethyldopa Br. J. Pharmacol. 70 1980 571 576
5. P. Burkhard, P. Dominici, C. Borri-Voltattorni, J.N. Jansonius, and V.N. Malashkevich Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase Nat. Struct. Biol. 8 2001 963 967
6. S. Cho, N.H. Neff, and M. Hadjiconstantinou Regulation of tyrosine hydroxylase and aromatic l-amino acid decarboxylase by dopaminergic drugs Eur. J. Pharmacol. 323 1997 149 157
7. G.C. Cotzias, M.H. Van Woert, and L.M. Schiffer Aromatic amino acids and modification of parkinsonism N. Engl. J. Med. 276 1967 374 379
8. O.T. DeJesus, C.J. Endres, S.E. Shelton, R.J. Nickles, and J.E. Holden Evaluation of fluorinated m-tyrosine analogs as PET imaging agents of dopamine nerve terminals: comparison with 6-fluoroDOPA J. Nucl. Med. 38 1997 630 636
9. O.T. DeJesus, C.J. Endres, S.E. Shelton, R.J. Nickles, and J.E. Holden Noninvasive assessment of aromatic l-amino acid decarboxylase activity in aging rhesus monkey brain in vivo Synapse 39 2001 58 63
10. P.R. Dunkley, L. Bobrovskaya, M.E. Graham, E.I. von Nagy-Felsobuki, and P.W. Dickson Tyrosine hydroxylase phosphorylation: regulation and consequences J. Neurochem. 91 2004 1025 1043
11. 11C-labeled suicide inactivators and PET Science 235 1987 481 485
12. C.R. Gardner CR, and M.H. Richards Use of d,l-alpha-monofluoromethyldopa to distinguish subcellular pools of aromatic amino acid decarboxylase in mouse brain Brain Res. 216 1981 291 298
13. O. Hornykiewicz Biochemical aspects of Parkinson's disease Neurology 51 1998 S2 S9
14. M.J. Jung, M.G. Palfreyman, J. Wagner, P. Bey, G. Ribereau-Gayon, M. Zraika, and J. Koch-Weser Inhibition of monoamine synthesis by irreversible blockade of aromatic amino acid decarboxylase with alpha-monofluoromethyldopa Life Sci. 24 1979 1037 1042
15. D.S. Kim, M.S. Szczypka, and R.D. Palmiter Dopamine-deficient mice are hypersensitive to dopamine receptor agonists J. Neurosci. 20 2000 4013 4405
16. C.S. Lee, A. Samii, V. Sossi, T.J. Ruth, M. Schulzer, J.E. Holden, J. Wudel, P.K. Pal, R. de la Fuente-Fernandez, D.B. Calne, and A.J. Stoessl In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease Ann. Neurol. 47 2000 493 503
17. X.M. Li, A.V. Juorio, and A.A. Boulton NSD-1015 alters the gene expression of aromatic l-amino acid decarboxylase in rat PC12 pheochromocytoma cells Neurochem. Res. 18 1993 915 919
18. A.L. Maycock, S.D. Aster, and A.A. Patchett Inactivation of 3-(3,4 dihydroxyphenyl) alanine decarboxylase by 2-(fluoromethyl)-3-(3,4- dihydroxyphenyl)alanine Biochemistry 19 1980 709 718
19. D. Murali, L.G. Flores, A.D. Roberts, R.J. Nickles, and O.T. DeJesus Aromatic l-amino acid decarboxylase (AAAD) inhibitors as carcinoid tumor-imaging agents: synthesis of 18F-labeled alpha-fluoromethyl-6-fluoro-m-tyrosine (FM-6-FmT) Appl. Radiat. Isot. 59 2003 237 243
20. M. Namavari, N. Satyamurthy, M.E. Phelps, and J.R. Barrio Synthesis of 6-[18F] and 4-[18F]fluoro-l-m-tyrosines via regioselective radiofluorodestannylation Appl. Radiat. Isot. 44 1993 527 536
21. N.H. Neff, and M. Hadjiconstantinou Aromatic l-amino acid decarboxylase modulation and Parkinson's disease Prog. Brain. Res. 106 1995 91 97
22. T.R. Oakes, (http://www.keck.waisman.wisc.edu/∼oakes/spam/ spam_frames.htm).
23. C.S. Patlak, and R.G. Blasberg Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations J. Cereb. Blood Flow Metab. 5 1985 584 590
24. 18F]F2 production Appl. Radiat. Isot. 46 1995 87 91
25. P. Seeman, D. Weinshenker, R. Quirion, L.K. Srivastava, S.K. Bhardwaj, D.K. Grandy, R.T. Premont, T.D. Sotnikova, P. Boksa, M. El-Ghundi, B.F. O'Dowd, S.R. George, M.L. Perreault, P.T. Mannisto, S. Robinson, R.D. Palmiter, and T. Tallerico Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis Proc. Natl. Acad. Sci. U. S. A. 102 2005 3513 3518
26. M.S. Szczypka, M.A. Rainey, D.S. Kim, W.A. Alaynick, B.T. Marck, A.M. Matsumoto, and R.D. Palmiter Feeding behavior in dopamine-deficient mice Proc. Natl. Acad. Sci. U. S. A. 1999 12138 12143
27. C. Tai, A. Chatziioannou, S. Siegel, J. Young, D. Newport, R.N. Goble, R.E. Nutt, and S.R. Cherry Performance evaluation of the microPET P4: a PET system dedicated to animal imaging Phys. Med. Biol. 46 2001 1845 1862
28. U. Ungerstedt Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system Acta Physiol. Scand., Suppl. 367 1971 69 93
29. M.Y. Zhu, A.V. Juorio, I.A. Paterson, and A.A. Boulton Regulation of striatal aromatic l-amino acid decarboxylase: effects of blockade or activation of dopamine receptors Eur. J. Pharmacol. 238 1993 157 164
30. M.J. Zigmond Do compensatory processes underlie the preclinical phase of neurodegenerative disease? Insights from an animal model of parkinsonism Neurobiol. Dis. 4 1997 247 253