Different proportions of aneusomic cells in ovarian inclusion cysts associated with serous borderline tumours and serous high-grade carcinomas support different pathogenetic pathways

Journal of Pathology

Volumn 207, Issue 1, 2005, Pages 20-26

  Körner, Meike ^a   Burckhardt, Elisabeth ^a   Mazzucchelli, Luca ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b INSTITUTE OF PATHOLOGY   (Switzerland)

Author keywords

Aneusomy; Fluorescence in situ hybridization (FISH); Ovarian cortical inclusion cyst; Ovarian serous tumour; Ovarian surface epithelium

Indexed keywords

ARTICLE; CANCER GRADING; CANCER PATIENT; CARCINOGENESIS; CELL CLONING; CELL INCLUSION; CENTROMERE; CHROMOSOMAL INSTABILITY; CHROMOSOME 1; CHROMOSOME 6; CHROMOSOME 7; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EPITHELIUM CELL; FEMALE; FEMALE GENITAL TRACT TUMOR; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC DIFFERENCE; GENETIC DISORDER; HUMAN; HUMAN CELL; HUMAN TISSUE; INVASIVE CARCINOMA; MONOSOMY X; OVARY CARCINOMA; OVARY CYST; OVARY TUMOR; PRIORITY JOURNAL; TRISOMY 7; X CHROMOSOME;

ANEUPLOIDY; CHROMOSOME ABERRATIONS; CYSTADENOCARCINOMA, SEROUS; DISEASE PROGRESSION; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; OVARIAN CYSTS; OVARIAN NEOPLASMS; PRECANCEROUS CONDITIONS;

EID: 23944513826     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1817     Document Type: Article

References (32)

1. Auersperg N, Wong AS, Choi KC, Kang SK, Leung PC. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr Rev 2001;22:255-288.
2. Bell DA, Scully RE. Early de novo ovarian carcinoma. Cancer 1994;73:1859-1864.
3. Mittal KR, Zeleniuch-Jacquotte A, Cooper JL, Demopoulos RI. Contralateral ovary in unilateral ovarian carcinoma: a search for preneoplastic lesions. Int J Gynecol Pathol 1993;21:59-63.
4. Werness BA, Afify AM, Bielat KL, Eltabbakh GH, Piver MS, Paterson JM. Altered surface and cyst epithelium of ovaries removed prophylactically from women with a family history of ovarian cancer. Hum Pathol 1999;30:151-157.
5. Resta L, Russo S, Colucci GA, Prat J. Morphologic precursors of ovarian epithelial tumors. Obstet Gynecol 1999; 82:181-186.
6. Singer G, Oldt R 3rd, Cohen Y, Wang BG, Sidransky D, Kurman RJ, et al. Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 2003; 95:484-486.
7. Shih IM, Kurman RJ. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol 2004;164:1511-1518.
8. Puls LE, Powell DE, DePriest PD, Gallion HH, Hunter JE, Kryscio RJ, et al. Transition from benign to malignant epithelium in mucinous and serous ovarian cystadenocarcinoma. Gynecol Oncol 1992;47:53-57.
9. Evans MF, McDicken IW, Herrington CS. Numerical abnormalities of chromosomes 1, 11, 17, and X are associated with stromal invasion in serous and mucinous epithelial ovarian tumors. J Pathol 1999; 189:53-59.
10. Diebold J, Deisenhofer I, Baretton GB, Blasenbreu S, Suchy B, Schneiderbanger K, et al. Interphase cytogenetic analysis of serous ovarian tumors of low malignant potential: comparison with serous cystadenomas and invasive serous carcinomas. Lab Invest 1996; 75:473-485.
11. Caduff RF, Svoboda-Newman SM, Ferguson AW, Johnston CM, Frank TS. Comparison of mutations of Ki-RAS and p53 immunoreactivity in borderline and malignant epithelial ovarian tumors. Am J Surg Pathol 1999;23:323-328.
12. Tangir J, Loughridge NS, Berkowitz RS, Muto MG, Bell DA, Welch WR, et al. Frequent microsatellite instability in epithelial borderline ovarian tumors. Cancer Res 1996;56:2501-2505.
13. Zheng J, Benedict WF, Xu HJ, Hu SX, Kim TM, Velicescu M, et al. Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas. J Natl Cancer Inst 1995;87:1146-1153.
14. Singer G, Stohr R, Cope L, Dehari R, Hartmann A, Cao DF, et al. Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation. Am J Surg Pathol 2005; 29:218-224.
15. Prat J, De Nictolis M. Serous borderline tumors of the ovary: a long-term follow-up study of 137 cases, including 18 with a micropapillary and 20 with microinvasion. Am J Surg Pathol 2002; 26:1111-1128.
16. Nguyen HN, Averette HE, Hoskins W, Sevin BU, Penalver M, Steren A. National survey of ovarian carcinoma. VI. Critical assessment of current International Federation of Gynecology and Obstetrics staging system. Cancer 1993;72:3007-3011.
17. Soldini D, Gugger M, Burckhardt E, Kappeler A, Laissue JA, Mazzucchelli L. Progressive genomic alterations in intraductal papillary mucinous tumours of the pancreas and morphologically similar lesions of the pancreatic ducts. J Pathol 2003;199:453-461.
18. Lynch HT, Casey MJ, Lynch J, White TE, Godwin AK. Genetics and ovarian carcinoma. Semin Oncol 1998;25:265-280.
19. Brock JA, Liu WH, Smith ST, Young SR. Detection of numerical chromosome anomalies in interphase cells of ovarian carcinomas using fluorescence in situ hybridization. Genes Chromosomes Cancer 1996;16:120-129.
20. Huang NF, Gupta M, Varghese S, Rao S, Luke S. Detection of numerical chromosomal abnormalities in epithelial ovarian neoplasms by fluorescence in situ hybridization (FISH) and a review of the current literature. Appl Immunohistochem Mol Morphol 2002; 10:187-193.
21. Kalir T, Eisberg A, Dottino P, Cohen C. Interphase fluorescence in situ hybridization studies of ovarian adenocarcinomas using the midisatellite probe. Gynecol Oncol 1999;72:208-214.
22. Persons DL, Hartmann LC, Herath JF, Borell TJ, Cliby WA, Keeney GL, et al. Interphase molecular cytogenetic analysis of epithelial ovarian carcinomas. Am J Pathol 1993; 142:733-741.
23. Tibiletti MG, Bernasconi B, Furlan D, Riva C, Trubia M, Buraggi G, et al. Early involvement of 6q in surface epithelial ovarian tumors. Cancer Res 1996;56:4493-4498.
24. Lee KR, Tavassoli FA, Prat J, Dietel M, Gersell DJ, Karseladze AI, et al. Surface epithelial-stromal tumours. In Pathology and Genetics of Tumours of the Breast and Female Genital Organs, Tavassoli FA, Devilee P (eds). IARC Press: Lyon, 2003; 117-145.
25. Silverberg SG, Bell DA, Kurman RJ, Seidman JD, Prat J, Ronnett BM, et al. Borderline ovarian tumors: key points and workshop summary. Hum Pathol 2004;35:910-917.
26. Seidman JD, Soslow RA, Vang R, Berman JJ, Stoler MH, Sherman ME, et al. Borderline ovarian tumors: diverse contemporary viewpoints on terminology and diagnostic criteria with illustrative images. Hum Pathol 2004;35:918-933.
27. Mazzucchelli L, Burckhardt E, Hirsiger H, Kappeler A, Laissue JA. Interphase cytogenetics in oncocytic adenomas and carcinomas of the thyroid gland. Hum Pathol 2000;31:854-859.
28. Hopman AH, van Hooren E, van de Kaa CA, Vooijs PG, Ramaekers FC. Detection of numerical chromosome aberrations using in situ hybridization in paraffin sections of routinely processed bladder cancers. Mod Pathol 1991;4:503-513.
29. Murdoch WJ, Townsend RS, McDonnel AC. Ovulation-induced DNA damage in ovarian surface epithelial cells of ewes: prospective regulatory mechanisms of repair/survival and apoptosis. Biol Reprod 2001;65:1417-1424.
30. Knuutila S, Aalto Y, Autio K, Bjorkqvist AM, El-Rifai, W, Hemmer S, et al. DNA copy number losses in human neoplasms. Am J Pathol 1999;155:683-694.
31. Auersperg N, Edelson MI, Mok SC, Johnson SW, Hamilton TC. The biology of ovarian cancer. Semin Oncol 1998;25:281-304.
32. Cheng PC, Gosewehr JA, Kim TM, Velicescu M, Wan M, Zheng J, et al. Potential role of the inactivated X chromosome in ovarian epithelial tumor development. J Natl Cancer Inst 1996; 88:480-482.