Determination of strychnine in human blood using solid-phase extraction and GC-EI-MS

Journal of Analytical Toxicology

Volumn 29, Issue 5, 2005, Pages 383-386

  Barroso, M ^a   Gallardo, E ^b   Margalho, C ^a   Marques, E ^a   Vieira, D N ^a   Lopez Rivadulla M ^b  

^a INSTITUTO NACIONAL DE MEDICINA LEGAL E CIÊNCIAS FORENSES   (Portugal)

^b Instituto de Medicina Legal   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

STRYCHNINE;

ACCURACY; BLOOD; BLOOD SAMPLING; CONFERENCE PAPER; DRUG DETERMINATION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; SOLID PHASE EXTRACTION; TOXICITY TESTING;

STRYCHNOS TOXIFERA;

EID: 23944509256     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/29.5.383     Document Type: Conference Paper

References (28)

1. M.L. Drost. Strychnine overdose in man. Can. Soc. Forens. Sci. J. 12:125-131 (1979).
2. K. Dittrich, M.J. Bayer, and L.A. Wanke. A case of fatal strychnine poisoning. J. Emer. Med. 1: 327-330 (1984).
3. D.M. Wood, E. Webster, D. Martinez, P.I. Dargan, and A.L. Jones. Case report: survival after deliberate strychnine self-poisoning, with toxicokinetic data. Crit. Care 6: 456-459 (2002).
4. C. Duverneuil, G.L. de la Grandmaison, P. de Mazancourt, and J.C. Alvarez. Liquid chromatography/photodiode array detection for determination of strychnine in blood: a fatal case report. Forensic Sci. Int. 141: 17-21 (2004).
5. W. Yamarick, P. Walson, and J. DiTraglia. Strychnine poisoning in an adolescent. J. Toxicol. Clin. Toxicol. 30: 141-148 (1992).
6. T.G. Rosano, J.D. Hubbard, J.M. Meola, and T.A. Swift. Fatal strychnine poisoning: application of gas chromatography and tandem mass spectrometry. J. Anal. Toxicol. 24: 642-647 (2000).
7. J.M. Heiser, M.R. Daya, A.R. Magnussen, R.L. Norton, D.A. Spyker, D.W. Allen, and W. Krasselt. Massive strychnine intoxication: serial blood levels in a fatal case. J. Toxicol. Clin. Toxicol. 30: 269-283 (1992).
8. R. Boyd, P.T. Brennan, J.F. Deng, D.F. Rochester, and D.A. Spyker. Strychnine poisoning: recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis. Am. J. Med. 74: 507-512 (1983).
9. T. Lindsey, J. O'Hara, R. Irvine, and S. Kerrigan. Strychnine overdose following ingestion of gopher bait. J. Anal. Toxicol. 28: 135-137 (2004).
10. C.L. Winek, W.W. Wahba, F.M. Esposito, and W.D. Collom. Fatal strychnine ingestion. J. Anal. Toxicol. 10: 120-121 (1986).
11. The International Association of Forensic Toxicologists. TIAFT-net-Therapeutic and Toxic Drug Concentrations List, http://www.tiaft.org/ tmembers/ttv/ttv_ps.html, May 2004.
12. G.P. Sgaragli and P.F. Mannaioni. Pharmacokinetic observations on a case of massive strychnine poisoning. Clin. Toxicol. 6: 533-540 (1973).
13. P. De Saqui-Sannes, P. Nups, P. Le Bars, and V. Burgat. Evaluation of an HPTLC method for the determination of strychnine and crimidine in biological samples. J. Anal. Toxicol. 20: 185-188 (1996).
14. E.P. Marques, F. Gil, P. Proença, P. Monsanto, M.F. Oliveira, A. Castanheira, and D.N. Vieira. Analytical method for the determination of strychnine in tissues by gas chromatography/mass spectrometry: two case reports. Forensic Sci. Int. 110: 145-152 (2000).
15. N. Platnow, H.S. Funnell, and W.T. Oliver. Determination of strychnine in biological materials by gas chromatography. J. Forensic Sci. 15: 443-446 (1970).
16. G. Miller, J. Warren, K. Gohre, and L. Hanks. Gas chromatography method for determining strychnine residues in alfalfa. J. Assoc. Off. Anal. Chem. 65: 901-903 (1982).
17. M. Cingolani, R. Froldi, R. Mencarelli, and D. Rodriguez. Analytical detection and quantitation of strychnine in chemically fixed organ tissues. J. Anal. Toxicol. 23: 219-221 (1999).
18. R. Greene and R. Meatherall. Dermal exposure to strychnine. J. Anal. Toxicol. 25: 344-347 (2001).
19. M.D. Crouch and C.R. Short. High pressure liquid chromatography determination of strychnine, using a reverse phase solvent system. J. Assoc. Off. Anal. Chem. 61: 612-615 (1978).
20. L. Alliot, G. Bryant, and P.S. Guth. Measurement of strychnine by high-performance liquid chromatography. J. Chromatogr. 232: 440-442 (1982).
21. R.T. Hunter and R.E. Creekmur. Liquid Chromatographic determination of strychnine as poison in domestic animals. J. Assoc. Off. Anal. Chem. 67: 542-545 (1984).
22. J.J.L. Hoogenboom and C.G. Rammel. Liquid Chromatographic determination of strychnine in stomach contents. J. Assoc. Off. Anal. Chem. 68: 1131-1133 (1985).
23. J.J. Johnston, E.E. Petty, I. Okuno, and D.L. Nolte. Comparison of reversed-phase and ion-pair chromatography for the determination of strychnine in animal tissues. J. Chromatogr. 6670: 73-79 (1995).
24. T. Egloff, A. Niederwieser, K. Pfister, A. Otten, B. Steinmann, W. Steiner, and R. Gitzelmann. A new high performance liquid chromatography (HPLC) method for the quantitation of strychnine in urine and tissue extracts. J. Clin. Chem. Clin. Biochem. 20: 203-206 (1982).
25. Z. Wang, J. Zhao, J. Xing, Y. He, and D. Guo. Analysis of strychnine and brucine in post-mortem specimens by PR-HPLC: a case report of fatal intoxication. J. Anal. Toxicol. 28: 141-144 (2004).
26. F.T. Peters and H.H. Maurer. Bioanalytical method validation and its implications for forensic and clinical toxicology - a review. Accredit. Qual. Assur. 7: 441-449 (2002).
27. Food and Drug Administration: U.S. Department of Health and Human Services. Guidance for Industry, Bioanalytical Method Validation, http://www.fda.gov/cder/guidance/4252fnl.pdf, January 2003.
28. International Conference on Harmonization (ICH). Validation of Analytical Procedures: Methodology ICH Q2 B, http://www.ich.org/MediaServer.jser?@_ID= 4188@_MODE=GLB, January 2003.