Cyclic AMP cascade mediates the inhibitory odor response of isolated toad olfactory receptor neurons

Journal of Neurophysiology

Volumn 94, Issue 3, 2005, Pages 1781-1788

  Madrid, Rodolfo ^a   Delgado, Ricardo ^a   Bacigalupo, Juan ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

6 ANILINO 5,8 QUINOLINEQUINONE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENYLATE CYCLASE; CALCIUM ION; CHARYBDOTOXIN; CHLORIDE CHANNEL; CHLORIDE ION; CYCLIC AMP; ENZYME INHIBITOR; IBERIOTOXIN; INOSITOL 1,4,5 TRISPHOSPHATE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ION CONDUCTANCE; NONHUMAN; ODOR; OLFACTORY NERVOUS SYSTEM; OLFACTORY RECEPTOR; POTASSIUM CURRENT; PRIORITY JOURNAL; SENSORY NERVE CELL; SIGNAL TRANSDUCTION;

ADENINE; AMINOQUINOLINES; ANIMALS; ANURA; CADAVERINE; CHARYBDOTOXIN; COMPLEX MIXTURES; CYCLIC AMP; DRUG INTERACTIONS; ELECTRIC STIMULATION; ENZYME INHIBITORS; MEMBRANE POTENTIALS; MODELS, NEUROLOGICAL; NEURAL CONDUCTION; NEURAL INHIBITION; ODORS; OLFACTORY RECEPTOR NEURONS; PATCH-CLAMP TECHNIQUES; SIGNAL TRANSDUCTION; ULTRAVIOLET RAYS;

EID: 23944507000     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.01253.2004     Document Type: Article

References (64)

1. Bacigalupo J, Morales B, and Labarca P. Inhibitory responses to odorants in vertebrate olfactory neurons. In: From Ion Channels to Cell-Cell Conversations, edited by Latorre R and Sáez JC. New York: Plenum Press, 1997, p. 269-281.
2. 3 pathways to olfactory responses in vertebrate olfactory receptor neurons and the specificity of odorants for both pathways. J Gen Physiol 22: 247-250, 2003.
3. Belluscio L, Gold GH, Nemes A, and Axel R. Mice deficient in G(olf) are anosmic. Neuron 20: 69-81, 1998.
4. Boekoff I, Tareilus E, Strotmann J, and Breer H. Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants. EMBO J 9: 2453-2458, 1990.
5. Bronshtein AA and Leont'ev VG. The sodium potassium content of the mucus of the olfactory epithelium of vertebrates. J Evol Biochem Physiol 8: 520-524, 1972.
6. Brunet LJ, Geoffrey HG, and Ngai J. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron 17: 681-693, 1996.
7. + channels from rat olfactory cilia characterized in planar lipid bilayers. FEBS Lett 579: 1675-1682, 2005.
8. Chen S, Lane AP, Bock R, Leinders-Zufall T, and Zufall F. Blocking adenylyl cyclase inhibits olfactory generator currents induced by "IP(3)-odors." J Neurophysiol 84: 575-580, 2000.
9. Chiu D, Nakamura T, and Gold GH. Ionic composition of toad olfactory mucus measure with ion selective microelectrodes. Chem Senses 13: 677-678ff, 1989.
10. Cunningham AM, Ryugo DK, Sharp AH, Reed RR, Snyder SH, and Ronnett GV. Neuronal inositol 1,4,5-trisphosphate receptor localized to the plasma membrane of olfactory cilia. Neuroscience 57: 339-352, 1993.
11. Delay R and Restrepo D. Odorant responses of dual polarity are mediated by cAMP in mouse olfactory sensory neurons. J Neurophysiol 92: 1312-1319, 2004.
12. + channels from chemosensory cilia of olfactory receptor neurons. Eur J Neurosci 20: 2975-2980, 2004.
13. Delgado R and Labarca P. Properties of whole-cell currents in isolated olfactory neurons from the Chilean toad Caudiverbera caudiverbera. Am J Physiol Cell Physiol 264: C1418-C1427, 1993.
14. + channels in chemosensory cilia support a role in odor transduction. J Neurophysiol 90: 2022-2028, 2003.
15. Dionne VE. Chemosensory responses in isolated olfactory receptor neurons from Necturus maculosus. J Gen Physiol 99: 415-433, 1992.
16. Dubin AE and Dionne VE. Action potential and chemosensitive conductance in the dendrites of olfactory neurons suggest new features for odor transduction. J Gen Physiol 103: 181-201, 1994.
17. Duchamp-Viret P, Chaput MA, and Duchamp A. Odor response properties of rat olfactory receptor neurons. Science 284: 2171-2174, 1999.
18. Ellis-Davies G, Kaplan J, and Barsotti RJ. Laser photolysis of caged calcium: rates of calcium release by nitrophenyl-EGTA and DM-nitrophen. Biophys J 70: 1006-1016, 1996.
19. Fesenko E, Kolesnikov S, and Lyubarsky A. Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment. Nature 313: 310-313, 1985.
20. Firestein S and Werblin F. Gated currents in isolated olfactory receptor neurons of the larval tiger salamander. Proc Natl Acad Sci USA 84: 6292-6296, 1987.
21. Firestein S and Werblin F. Odor induced membrane currents in vertebrate olfactory receptor neurons. Science 244: 79-82, 1989.
22. Gesteland RC, Lettvin JY, and Pitts WH. Chemical transmission in the nose of the frog. J Physiol 181: 525-559, 1965.
23. Gold GH. Controversial issues in vertebrate olfactory transduction. Annu Rev Physiol 61: 857-871, 1999.
24. Jaramillo F and Hudspeth AJ. Localization of the hair cell's transduction channels at the hair bundle's top by iontophoretic application of a channel blocker. Neuron 7: 409-420, 1991.
25. Johnson EC and Bacigalupo J. Spontaneous activity of the light-dependent channel irreversibly induced in excised patches from Limulus ventral photoreceptors. J Membr Biol 130: 33-47, 1992.
26. Joshi H, Getchell ML, Zielinski B, and Getchell TV. Spectrophotometric determination of cation concentration in olfactory mucus. Neurosci Lett 82: 321-326, 1987.
27. Kang J and Caprio J. In vivo responses of single olfactory receptor neurons in the channel catfish, Ictalurus punctatus. J Neurophysiol 73: 172-177, 1995.
28. Kleene S and Gesteland R. Calcium-activated chloride conductance in frog olfactory cilia. J Neurosci 11: 3624-3629, 1991.
29. Kleene SJ. Origin of the chloride current in olfactory transduction. Neuron 11: 123-132, 1993.
30. Kurahashi T. Activation by odorants of cation-selective conductance in the olfactory receptor cell isolated from the newt. J Physiol 419: 177-192, 1989.
31. Kurahashi T. The response induced by intracellular cyclic AMP in isolated olfactory receptor cells in the newt. J Physiol 430: 355-371, 1990.
32. Kurahashi T and Kaneko A. High density cAMP-gated channels at the ciliary membrane in the olfactory receptor cell. Neuroreport 2: 5-8, 1991.
33. Kurahashi T and Menini A. Mechanism of odorant adaptation in the olfactory receptor cell. Nature 385: 725-729, 1997.
34. Kurahashi T and Yau KW. Co-existence of cationic and chloride components of odorant-induced current of vertebrate olfactory receptor neurons. Nature 363: 71-74, 1993.
35. Leinders-Zufall T, Rand M, Shepherd GM, Greer CA, and Zufall F. Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics. J Neurosci 17: 4136-4148, 1997.
36. Leinders-Zufall T and Zufall F. Block of cyclic nucleotide-gated channels in salamander olfactory receptor neurons by the guanylyl cyclase inhibitor LY83583. J Neurophysiol 74: 2759-2762, 1995.
37. Lowe G and Gold GH. Contribution of the ciliary cyclic nucleotide-gated conductance to olfactory transduction in the salamander. J Physiol 462: 175-196, 1993a.
38. Lowe G and Gold GH. Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature 366: 283-286, 1993b.
39. Madrid R, Sanhueza M, Alvarez O, and Bacigalupo J. Tonic and phasic receptor neurons in the vertebrate olfactory epithelium. Biophys J 84: 4167-4181, 2003.
40. Malnic B, Hirono J, Sato T, and Buck LB. Combinatorial receptor codes for odors. Cell 96: 713-723, 1999.
41. Mombaerts P. Genes and ligands for odorant, vomeronasal and taste receptors. Nat Rev Neurosci 5: 263-278, 2004.
42. Morales B, Labarca P, and Bacigalupo J. A ciliary conductance sensitive to charybdotoxin underlies inhibitory responses in toad olfactory receptor neurons. FEBS Lett 359: 41-44, 1995.
43. Morales B, Madrid R, and Bacigalupo J. Calcium mediates the activation of the inhibitory current induced by odorants in toad olfactory receptor neurons. FEBS Lett 402: 259-264, 1997.
44. + currents activated by odorants in toad olfactory neurons. Proc R Soc Lond B Biol Sci 257: 235-242, 1994.
45. Nakamura T and Gold GH. A cyclic-nucleotide gated conductance in olfactory-receptor cilia. Nature 325: 442-444, 1987.
46. Nasi E and Gomez MP. Light-activated ion channels in solitary photoreceptors of the scallop Pecten irradians. J Gen Physiol 99: 747-769, 1992.
47. O'Connell RJ and Mozell MM. Quantitative stimulation of frog olfactory receptors. J Neurophysiol 32: 51-63, 1969.
48. Pun R and Kleene S. Outward currents in olfactory receptor neurons activated by odorants and by elevation of cyclic AMP. Cell Biochem Biophys 37: 15-26, 2002.
49. Restrepo D, Miyamoto T, Bryant BP, and Teeter JH. Odor stimuli trigger influx of calcium into olfactory neurons of the channel catfish. Science 249: 1166-1168, 1990.
50. Reuter D, Zierold K, Schröder WH, and Frings S. A depolarizing chloride current contributes to chemoelectrical transduction in olfactory sensory neurons in situ. J Neurosci 18: 6623-6630, 1998.
51. Sanhueza M, Schmachtenberg O, and Bacigalupo J. Excitation, inhibition, and suppression by odors in isolated toad and rat olfactory receptor neurons. Am J Physiol Cell Physiol 279: C31-C39, 2000.
52. Schild D and Restrepo D. Transduction mechanisms in vertebrate olfactory receptor cells. Physiol Rev 78: 429-466, 1998.
53. 2+], by activating two distinct components in vertebrate olfactory receptor cells. J Neurophysiol 89: 862-866, 1995.
54. Serizawa S, Miyamichi K, Nakatani H, Suzuki M, Saito M, Yoshihara Y, and Sakano H. Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science 302: 2088-2094, 2003.
55. Stern J, Chinn K, Bacigalupo J, and Lisman J. Distinct lobes of Limulus ventral photoreceptors. I. Functional and anatomical properties of lobes revealed by removal of glial cells. J Gen Physiol 80: 825-837, 1982.
56. Takeuchi H, Imanaka Y, Hirono J, and Kurahashi T. Cross-adaptation between olfactory responses induced by two subgroups of odorant molecules. J Gen Physiol 122: 255-264, 2003.
57. Takeuchi H and Kurahashi T. Photolysis of caged cyclic AMP in the ciliary cytoplasm of the newt olfactory receptor cell. J Physiol 541: 825-833, 2002.
58. Takeuchi H and Kurahashi T. Identification of second messenger mediating signal transduction in the olfactory receptor cell. J Gen Physiol 122: 557-567, 2003.
59. Trotier D. A patch clamp analysis of membrane currents in salamander olfactory cells. Pflügers Arch 407: 589-595, 1986.
60. Vogler C and Schild D. Inhibitory and excitatory responses of olfactory receptor neurons of Xenopus to stimulation with amino acids. J Exp Biol 202: 997-1003, 1999.
61. Wong ST, Trinh K, Hacker B, Chan GC, Lowe G, Gaggar A, Xia Z, Gold GH, and Storm DR. Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron 27: 487-497, 2000.
62. Yau KW and Baylor DA. Cyclic GMP-activated conductance of retinal photoreceptor cells. Annu Rev Neurosci 12: 289-327, 1989.
63. Zufall F, Firestein S, and Shepherd GM. Analysis of single cyclic nucleotide-gated channels in olfactory receptor cells. J Neurosci 11: 3573-3580, 1991.
64. 2+ release and its role in olfactory signal transduction. J Neurophysiol 83: 501-512, 2000.