The first synthesis of novel (1-alkoxycarbonyloxyethylidene)-1,1- bisphosphonic acid derivatives taking advantage of the rearrangement characteristic of the tetramethyl ester of etidronate

Synthesis

Volumn , Issue 13, 2005, Pages 2119-2121

  Turbanen, Petri A ^a   Vepsäläinen, Jouko J ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Bisphosphonate; Ester; Etidronate; Prodrug; Synthesis

Indexed keywords

DERIVATIVES; DRUG PRODUCTS; ESTERS; SYNTHESIS (CHEMICAL);

BISPHOSPHONATE; ETIDRONATE; PRODRUG;

ORGANIC ACIDS;

(1 ALKOXYCARBONYLOXYETHYLIDENE) 1,1 BIPHOSPHONIC ACID; ALKOXYCARBONYL CHLORIDE; BISPHOSPHONIC ACID DERIVATIVE; ETIDRONIC ACID; PRODRUG; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CARBONYLATION; CATALYST; COLUMN CHROMATOGRAPHY; DEMETHYLATION; DRUG ISOLATION; REACTION ANALYSIS; REACTION TIME; SILYLATION;

EID: 23944493710     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-869984     Document Type: Article

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