Effects of N-glycosylation and inositol on the ER stress response in yeast Saccharomyces cerevisiae

Bioscience, Biotechnology and Biochemistry

Volumn 69, Issue 7, 2005, Pages 1274-1280

  Uchimura, Seiichi ^a   Sugiyama, Minetaka ^a,b   Nikawa, Jun Ichi ^a  

^a KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Endoplasmic reticulum (ER) stress response; INO1; Inositol; N glycosylation; Yeast

Indexed keywords

GLUCOSE; PROTEINS; QUALITY CONTROL; STRESS ANALYSIS; SYNTHESIS (CHEMICAL);

ENDOPLASMIC RETICULUM (ER) STRESS RESPONSE; INOSITOL; N-GLYCOSYLATION;

YEAST;

ALG8 PROTEIN, S CEREVISIAE; CARRIER PROTEIN; DIE2 PROTEIN, S CEREVISIAE; FUNGAL PROTEIN; GLUCOSYLTRANSFERASE; HEAT SHOCK PROTEIN 70; INOSITOL; ITR1 PROTEIN, S CEREVISIAE; KAR2 PROTEIN, YEAST; SACCHAROMYCES CEREVISIAE PROTEIN; TUNICAMYCIN;

ARTICLE; CELL DIVISION; COMPARATIVE STUDY; CULTURE MEDIUM; DRUG EFFECT; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; GLYCOSYLATION; METABOLISM; MUTATION; PHENOTYPE; SACCHAROMYCES CEREVISIAE;

CELL DIVISION; CULTURE MEDIA; ENDOPLASMIC RETICULUM; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENOTYPE; GLUCOSYLTRANSFERASES; GLYCOSYLATION; HSP70 HEAT-SHOCK PROTEINS; INOSITOL; MEMBRANE TRANSPORT PROTEINS; MUTATION; PHENOTYPE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TUNICAMYCIN;

SACCHAROMYCES CEREVISIAE;

EID: 23944490199     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.69.1274     Document Type: Article

References (30)

1. Sidrauski, C., Chapman, R., and Walter, P., The unfolded protein response: an intracellular signaling pathway with many surprising features. Trends Cell. Biol., 8, 245-249 (1998).
2. Kaufman, R. J., Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev., 13, 1211-1233 (1999).
3. Mori, K., Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell, 101, 451-454 (2000).
4. Kohno, K., Normington, K., Sambrook, J., Gething, M. J., and Mori, K., The promoter region of the yeast KAR2(BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum. Mol. Cell. Biol., 13, 877-890 (1993).
5. Cox, J. S., Shamu, C. E., and Walter, P., Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell, 73, 1197-1206 (1993).
6. Mori, K., Ma, W., Gething, M.-J., and Sambrook, J., A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell, 74, 743-756 (1993).
7. Cox, J. S., and Walter, P., A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell, 87, 394-404 (1996).
8. Nikawa, J., and Yamashita, S., IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol prototrophy in Saccharomyces cerevisiae. Mol. Microbiol., 6, 1441-1446 (1992).
9. Nikawa, J., Akiyoshi, M., Hirata, S., and Fukuda, T., Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression. Nucl. Acids Res., 24, 4222-4226 (1996).
10. Dean-Johnson, M., and Henry, S., Biosynthesis of inositol in yeast: primary structure of myo-inositol-1-phosphate synthase (EC 5.5.1.4) and functional analysis of its structural gene, the INO1 locus. J. Biol. Chem., 264, 1274-1283 (1989).
11. Nikawa, J., Tsukagoshi, Y., and Yamashita, S., Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae. J. Biol. Chem., 266, 11184-11191 (1991).
12. Nikawa, J., Hosaka, K., and Yamashita, S., Differential regulation of two myo-inositol transporter genes of Saccharomyces cerevisiae. Mol. Microbiol., 10, 955-961 (1993).
13. Paltauf, F., Kohlwein, S. D., and Henry, S. A., "The Molecular and Cellular Biology of the Yeast Saccharomyces" Vol. 2, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1992).
14. Greenberg, M. L., and Lopes, J. M., Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae. Microbiol. Rev., 60, 1-20 (1996).
15. Nikawa, J., and Hosaka, K., Isolation and characterization of genes that promote the expression of inositol transporter gene ITR1 in Saccharomyces cerevisiae. Mol. Microbiol., 16, 301-308 (1995).
16. Burda, P., and Aebi, M., The ALG10 locus of Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum: the terminal glucose of the lipid-linked oligosaccharide is required for efficient N-linked glycosylation. Glycobiology, 8, 455-462 (1998).
17. Imbach, T., Burda, P., Kuhnert, P., Wevers, R. A., Aebi, M., Berger, E. G., and Kennet, T., A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic. Proc. Natl. Acad. Sci. U.S.A., 96, 6982-6987 (1999).
18. Stagljar, I., te Heesen, S., and Aebi, M., New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locus. Proc. Natl. Acad. Sci. U.S.A., 91, 5977-5981 (1994).
19. Jakob, C. A., Burda, P., Roth, J., and Aebi, M., Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure. J. Cell. Biol., 142, 1223-1233 (1998).
20. Maniatis, T., Fritsch, E. F., and Sambrook, J., Molecular cloning: a laboratory manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1982).
21. Nikawa, J., and Kawabata, M., PCR- and ligation-mediated synthesis of marker cassettes with long flanking homology regions for gene disruption in Saccharomyces cerevisiae. Nucl. Acids Res., 26, 860-861 (1998).
22. Clark, J. M., Novel non-templated nucleotide addition reactions catalyzed by procaryotic and eucaryotic DNA polymerases. Nucl. Acids Res., 16, 9677-9686 (1988).
23. Yamashita, S., and Oshima, A., Regulation of phosphatidylethanolamine methyltransferase level by myo-inositol in Saccharomyces cerevisiae. Eur. J. Biochem., 104, 611-616 (1980).
24. Ito, H., Fukuda, Y., Murata, K., and Kimura, A., Transformation of intact yeast cells treated with alkali cations. J. Bacteriol., 153, 163-168 (1983).
25. Sugiyama, M., and Nikawa, J., The Saccharomyces cerevisiae Isw2p-Itc1p complex represses INO1 expression and maintains cell morphology. J. Bacteriol., 183, 4985-4993 (2001).
26. Hosaka, K., Murakami, T., Kodaki, T., Nikawa, J., and Yamashita, S., Repression of choline kinase by inositol and choline in Saccharomyces cerevisiae. J. Bacteriol., 172, 2005-2012 (1990).
27. Kostova, Z., and Wolf, D. H., For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection. EMBO J., 22, 2309-2317 (2003).
28. Ellgaard, L., and Helenius, A., Quality control in the endoplasmic reticulum. Mol. Cell. Biol., 4, 181-191 (2003).
29. McLaurin, J., Golomb, R., Jurewicz, A., Antel, J. P., and Fraser, P. E., Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid β peptide and inhibit Aβ-induced toxicity. J. Biol. Chem., 275, 18495-18502 (2000).
30. Cox, J. S., Chapman, R. E., and Walter, P., The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane. Mol. Biol. Cell, 8, 1805-1814 (1997).