Involvement of glutamate mutase in the biosynthesis of the unique starter unit of the macrolactam polyketide antibiotic vicenistatin

Journal of Antibiotics

Volumn 58, Issue 7, 2005, Pages 468-472

  Ogasawara, Yasushi ^a   Kakinuma, Katsumi ^a   Eguchi, Tadashi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Antitumor antibiotic; Gene disruption; Glutamate mutase; Macrolactam; Polyketide; Vicenistatin

Indexed keywords

3 METHYLASPARTATE; ANTIBIOTIC AGENT; ASPARTIC ACID; MACROLACTAM ANTIBIOTIC; METHYLASPARTATE MUTASE; MUTASE; NORVICENISTATIN DERIVATIVE; POLYKETIDE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; VICENISTATIN; VICENISTATIN DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BIOSYNTHESIS; DRUG STRUCTURE; ENZYME ACTIVITY; GENE; GENE CLUSTER; GENE FUNCTION; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES HALSTEDII; VINI GENE;

STREPTOMYCES HALSTEDII; VINI;

EID: 23944483141     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2005.62     Document Type: Article

References (10)

1. Shindo K, Kamishohara M, Odagawa A, Matsuoka M, Kawai H. Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic. J Antibiot 46: 1076-1081 (1993)
2. Otsuka M, Eguchi T, Shindo K, Kakinuma K. Non-fatty acyl polyketide starter in the biosynthesis of vicenistatin, an antitumor macrolactam antibiotic. Tetrahedron Lett 39: 3185-3188 (1998)
3. Otsuka M, Fujita M, Matsushima Y, Eguchi T, Shindo K, Kakinuma K. Biosynthetic pathway of macrolactam polyketide glycoside antitumor antibiotic vicenistatins. Tetrahedron 56: 8281-8286 (2000)
4. Nishida H, Eguchi T, Kakinuma K. Amino acid starter unit in the biosynthesis of macrolactam polyketide antitumor antibiotic vicenistatin. Tetrahedron 57: 8237-8242 (2001)
5. Hoffmann B, Konrat R, Bothe H, Buckel W, Krautler B. Structure and dynamics of the B12-binding subunit of glutamate mutase from Clostridium cochlearium. Eur J Biochem 263: 178-188 (1999)
6. Ogasawara Y, Katayama K, Minami A, Otsuka M, Eguchi T, Kakinuma K. Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii. Chem Biol 11: 79-86 (2004)
7. Vara J, Lewandowska-Skarbek M, Wang YG, Donadio S, Hutchinson CR. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus). J Bacteriol 171: 5872-5881 (1989)
8. Blondelet-Rouault MH, Weiser J, Lebrihi A, Branny P, Pernodet JL. Antibiotic resistance gene cassettes derived from the omega interposon for use in E. coli and Streptomyces. Gene 190: 315-317 (1997)
9. Tamiya N, Oshima T. Synthesis of deuterium derivatives of L-aspartic acid. J Biochem 51: 78-88 (1962)
10. 4. J Labeled Compd Radiopharm 25: 217-224 (1987)