메뉴 건너뛰기




Volumn 143, Issue 2, 2005, Pages 200-208

Functional expression of the gene encoding cytidine triphosphate synthetase from Plasmodium falciparum which contains two novel sequences that are potential antimalarial targets

Author keywords

CTP synthetase; Heterologous expression; Insert; PCR mediated gene synthesis

Indexed keywords

ANTIBODY; CYTIDINE TRIPHOSPHATE SYNTHASE; RECOMBINANT ENZYME;

EID: 23944479424     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2005.06.004     Document Type: Article
Times cited : (10)

References (32)
  • 1
    • 0033999271 scopus 로고    scopus 로고
    • Overcoming codon bias: A method for high-level overexpression of Plasmodium and other AT-rich parasite genes in Escherichia coli
    • A.M. Baca, and W.G. Hol Overcoming codon bias: a method for high-level overexpression of Plasmodium and other AT-rich parasite genes in Escherichia coli Int J Parasitol 30 2 2000 113 118
    • (2000) Int J Parasitol , vol.30 , Issue.2 , pp. 113-118
    • Baca, A.M.1    Hol, W.G.2
  • 2
    • 0027369381 scopus 로고
    • Co-overexpression of bacterial GroESL chaperonins partly overcomes non-productive folding and tetramer assembly of E. coli-expressed human medium-chain acyl-CoA dehydrogenase (MCAD) carrying the prevalent disease-causing K304E mutation
    • P. Bross, B.S. Andresen, and V. Winter Co-overexpression of bacterial GroESL chaperonins partly overcomes non-productive folding and tetramer assembly of E. coli-expressed human medium-chain acyl-CoA dehydrogenase (MCAD) carrying the prevalent disease-causing K304E mutation Biochim Biophys Acta 1182 3 1993 264 274
    • (1993) Biochim Biophys Acta , vol.1182 , Issue.3 , pp. 264-274
    • Bross, P.1    Andresen, B.S.2    Winter, V.3
  • 3
    • 0035074340 scopus 로고    scopus 로고
    • Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections
    • E. De Clercq Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections Clin Microbiol Rev 14 2 2001 382 397
    • (2001) Clin Microbiol Rev , vol.14 , Issue.2 , pp. 382-397
    • De Clercq, E.1
  • 4
    • 0028587356 scopus 로고
    • Characterisation of the carbamoyl phosphate synthetase gene from Plasmodium falciparum
    • M.V. Flores, W.J. O'Sullivan, and T.S. Stewart Characterisation of the carbamoyl phosphate synthetase gene from Plasmodium falciparum Mol Biochem Parasitol 68 2 1994 315 318
    • (1994) Mol Biochem Parasitol , vol.68 , Issue.2 , pp. 315-318
    • Flores, M.V.1    O'Sullivan, W.J.2    Stewart, T.S.3
  • 5
    • 0027490493 scopus 로고
    • Molecular characterization of the largest subunit of Plasmodium falciparum RNA polymerase I
    • B.A. Fox, W.B. Li, M. Tanaka, J. Inselburg, and D.J. Bzik Molecular characterization of the largest subunit of Plasmodium falciparum RNA polymerase I Mol Biochem Parasitol 61 1 1993 37 48
    • (1993) Mol Biochem Parasitol , vol.61 , Issue.1 , pp. 37-48
    • Fox, B.A.1    Li, W.B.2    Tanaka, M.3    Inselburg, J.4    Bzik, D.J.5
  • 6
    • 0034110319 scopus 로고    scopus 로고
    • Potentiation of the anti-HIV activity of zalcitabine and lamivudine by a CTP synthase inhibitor, 3-deazauridine
    • W.Y. Gao, D.G. Johns, and H. Mitsuya Potentiation of the anti-HIV activity of zalcitabine and lamivudine by a CTP synthase inhibitor, 3-deazauridine Nucleosides Nucleotides Nucl Acids 19 1-2 2000 371 377
    • (2000) Nucleosides Nucleotides Nucl Acids , vol.19 , Issue.1-2 , pp. 371-377
    • Gao, W.Y.1    Johns, D.G.2    Mitsuya, H.3
  • 7
    • 0021687250 scopus 로고
    • Pyrimidine de novo synthesis during the life cycle of the intraerythrocytic stage of Plasmodium falciparum
    • A.M. Gero, G.V. Brown, and W.J. O'Sullivan Pyrimidine de novo synthesis during the life cycle of the intraerythrocytic stage of Plasmodium falciparum J Parasitol 70 4 1984 536 541
    • (1984) J Parasitol , vol.70 , Issue.4 , pp. 536-541
    • Gero, A.M.1    Brown, G.V.2    O'Sullivan, W.J.3
  • 8
    • 0025260156 scopus 로고
    • Purines and pyrimidines in malarial parasites
    • A.M. Gero, W.J. O'Sullivan, Purines and pyrimidines in malarial parasites, Blood Cells 1990;16(2-3):467-84; discussion 485-98.
    • (1990) Blood Cells , vol.16 , Issue.2-3 , pp. 467-484
    • Gero, A.M.1    O'Sullivan, W.J.2
  • 9
    • 4143092510 scopus 로고    scopus 로고
    • Crystal structures of CTP synthetase reveal ATP, UTP, and glutamine binding sites
    • M. Goto, R. Omi, N. Nakagawa, I. Miyahara, and K. Hirotsu Crystal structures of CTP synthetase reveal ATP, UTP, and glutamine binding sites Structure (Camb) 12 8 2004 1413 1423
    • (2004) Structure (Camb) , vol.12 , Issue.8 , pp. 1413-1423
    • Goto, M.1    Omi, R.2    Nakagawa, N.3    Miyahara, I.4    Hirotsu, K.5
  • 10
    • 0028365432 scopus 로고
    • A cytidine triphosphate synthetase gene in Plasmodium falciparum
    • E.F. Hendriks, W.J. O'Sullivan, and T.S. Stewart A cytidine triphosphate synthetase gene in Plasmodium falciparum Int J Parasitol 24 3 1994 397 399
    • (1994) Int J Parasitol , vol.24 , Issue.3 , pp. 397-399
    • Hendriks, E.F.1    O'Sullivan, W.J.2    Stewart, T.S.3
  • 11
    • 0032552035 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the Plasmodium falciparum cytidine triphosphate synthetase gene
    • E.F. Hendriks, W.J. O'Sullivan, and T.S. Stewart Molecular cloning and characterization of the Plasmodium falciparum cytidine triphosphate synthetase gene Biochim Biophys Acta 1399 2-3 1998 213 218
    • (1998) Biochim Biophys Acta , vol.1399 , Issue.2-3 , pp. 213-218
    • Hendriks, E.F.1    O'Sullivan, W.J.2    Stewart, T.S.3
  • 12
    • 0035933201 scopus 로고    scopus 로고
    • Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness
    • A. Hofer, D. Steverding, A. Chabes, R. Brun, and L. Thelander Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness Proc Natl Acad Sci USA 98 11 2001 6412 6416
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.11 , pp. 6412-6416
    • Hofer, A.1    Steverding, D.2    Chabes, A.3    Brun, R.4    Thelander, L.5
  • 13
    • 0028108331 scopus 로고
    • CTP synthetase and enzymes of pyrimidine ribonucleotide metabolism in Giardia intestinalis
    • B.M. Jimenez, and W.J. O'Sullivan CTP synthetase and enzymes of pyrimidine ribonucleotide metabolism in Giardia intestinalis Int J Parasitol 24 5 1994 713 718
    • (1994) Int J Parasitol , vol.24 , Issue.5 , pp. 713-718
    • Jimenez, B.M.1    O'Sullivan, W.J.2
  • 14
    • 0024570138 scopus 로고
    • Cyclopentenylcytosine triphosphate. Formation and inhibition of CTP synthetase
    • G.J. Kang, D.A. Cooney, and J.D. Moyer Cyclopentenylcytosine triphosphate. Formation and inhibition of CTP synthetase J Biol Chem 264 2 1989 713 718
    • (1989) J Biol Chem , vol.264 , Issue.2 , pp. 713-718
    • Kang, G.J.1    Cooney, D.A.2    Moyer, J.D.3
  • 15
    • 77956915376 scopus 로고
    • CTP synthetase and related enzymes
    • P.D. Boyer Academic Press New York
    • D.E. Koshland, and A. Levitzki CTP synthetase and related enzymes P.D. Boyer Enzymes vol. 10 1974 Academic Press New York 539 559
    • (1974) Enzymes , vol.10 , pp. 539-559
    • Koshland, D.E.1    Levitzki, A.2
  • 16
    • 0029929732 scopus 로고    scopus 로고
    • Isolation, characterization and expression of the gene encoding cytidine triphosphate synthetase from Giardia intestinalis
    • R.L. Lim, W.J. O'Sullivan, and T.S. Stewart Isolation, characterization and expression of the gene encoding cytidine triphosphate synthetase from Giardia intestinalis Mol Biochem Parasitol 78 1-2 1996 249 257
    • (1996) Mol Biochem Parasitol , vol.78 , Issue.1-2 , pp. 249-257
    • Lim, R.L.1    O'Sullivan, W.J.2    Stewart, T.S.3
  • 17
    • 0014217178 scopus 로고
    • Cytidine triphosphate synthetase of Escherichia coli B. I. Purification and kinetics
    • C.W. Long, and A.B. Pardee Cytidine triphosphate synthetase of Escherichia coli B. I. Purification and kinetics J Biol Chem 242 20 1967 4715 4721
    • (1967) J Biol Chem , vol.242 , Issue.20 , pp. 4715-4721
    • Long, C.W.1    Pardee, A.B.2
  • 18
    • 0040115912 scopus 로고    scopus 로고
    • The putative gamma-glutamylcysteine synthetase from Plasmodium falciparum contains large insertions and a variable tandem repeat
    • K. Luersen, R.D. Walter, and S. Muller The putative gamma- glutamylcysteine synthetase from Plasmodium falciparum contains large insertions and a variable tandem repeat Mol Biochem Parasitol 98 1 1999 131 142
    • (1999) Mol Biochem Parasitol , vol.98 , Issue.1 , pp. 131-142
    • Luersen, K.1    Walter, R.D.2    Muller, S.3
  • 19
    • 0033966840 scopus 로고    scopus 로고
    • Assembly and expression of a synthetic gene encoding the antigen Pfs48/45 of the human malaria parasite Plasmodium falciparum in yeast
    • R.L. Milek, H.G. Stunnenberg, and R.N. Konings Assembly and expression of a synthetic gene encoding the antigen Pfs48/45 of the human malaria parasite Plasmodium falciparum in yeast Vaccine 18 14 2000 1402 1411
    • (2000) Vaccine , vol.18 , Issue.14 , pp. 1402-1411
    • Milek, R.L.1    Stunnenberg, H.G.2    Konings, R.N.3
  • 20
    • 0030665841 scopus 로고    scopus 로고
    • Molecular cloning, characterization and localization of PfPK4, an eIF-2alpha kinase-related enzyme from the malarial parasite Plasmodium falciparum
    • J.J. Mohrle, Y. Zhao, B. Wernli, R.M. Franklin, and B. Kappes Molecular cloning, characterization and localization of PfPK4, an eIF-2alpha kinase-related enzyme from the malarial parasite Plasmodium falciparum Biochem J 328 Pt 2 1997 677 687
    • (1997) Biochem J , vol.328 , Issue.2 PART , pp. 677-687
    • Mohrle, J.J.1    Zhao, Y.2    Wernli, B.3    Franklin, R.M.4    Kappes, B.5
  • 21
    • 0032568837 scopus 로고    scopus 로고
    • Nucleotide-dependent tetramerization of CTP synthetase from Saccharomyces cerevisiae
    • A. Pappas, W.L. Yang, T.S. Park, and G.M. Carman Nucleotide-dependent tetramerization of CTP synthetase from Saccharomyces cerevisiae J Biol Chem 273 26 1998 15954 15960
    • (1998) J Biol Chem , vol.273 , Issue.26 , pp. 15954-15960
    • Pappas, A.1    Yang, W.L.2    Park, T.S.3    Carman, G.M.4
  • 22
    • 0027968768 scopus 로고
    • Cytidine triphosphate synthetase activity in asexual blood stages of Plasmodium falciparum
    • J.L. Perignon, M. Hamet, and P. Druilhe Cytidine triphosphate synthetase activity in asexual blood stages of Plasmodium falciparum Mol Biochem Parasitol 67 1 1994 179 182
    • (1994) Mol Biochem Parasitol , vol.67 , Issue.1 , pp. 179-182
    • Perignon, J.L.1    Hamet, M.2    Druilhe, P.3
  • 23
    • 0028216602 scopus 로고
    • Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum
    • K.K. Seymour, S.D. Lyons, L. Phillips, K.H. Rieckmann, and R.I. Christopherson Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum Biochemistry 33 17 1994 5268 5274
    • (1994) Biochemistry , vol.33 , Issue.17 , pp. 5268-5274
    • Seymour, K.K.1    Lyons, S.D.2    Phillips, L.3    Rieckmann, K.H.4    Christopherson, R.I.5
  • 24
    • 0023762645 scopus 로고
    • Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; A review of the considerable within-species diversity
    • P.M. Sharp, E. Cowe, D.G. Higgins, D.C. Shields, K.H. Wolfe, and F. Wright Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversity Nucl Acids Res 16 17 1988 8207 8211
    • (1988) Nucl Acids Res , vol.16 , Issue.17 , pp. 8207-8211
    • Sharp, P.M.1    Cowe, E.2    Higgins, D.G.3    Shields, D.C.4    Wolfe, K.H.5    Wright, F.6
  • 25
    • 0035644195 scopus 로고    scopus 로고
    • Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3
    • P.S. Sijwali, B.R. Shenai, J. Gut, A. Singh, and P.J. Rosenthal Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3 Biochem J 360 Pt 2 2001 481 489
    • (2001) Biochem J , vol.360 , Issue.2 PART , pp. 481-489
    • Sijwali, P.S.1    Shenai, B.R.2    Gut, J.3    Singh, A.4    Rosenthal, P.J.5
  • 26
    • 0023919718 scopus 로고
    • Purification of cytidine-triphosphate synthetase from rat liver, and demonstration of monomer, dimer and tetramer
    • P.E. Thomas, B.J. Lamb, and E.H. Chu Purification of cytidine- triphosphate synthetase from rat liver, and demonstration of monomer, dimer and tetramer Biochim Biophys Acta 953 3 1988 334 344
    • (1988) Biochim Biophys Acta , vol.953 , Issue.3 , pp. 334-344
    • Thomas, P.E.1    Lamb, B.J.2    Chu, E.H.3
  • 27
    • 0034093433 scopus 로고    scopus 로고
    • Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: A promising target for chemotherapy
    • A.C. Verschuur, A.H. Van Gennip, and R. Leen Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy Eur J Cancer 36 5 2000 627 635
    • (2000) Eur J Cancer , vol.36 , Issue.5 , pp. 627-635
    • Verschuur, A.C.1    Van Gennip, A.H.2    Leen, R.3
  • 29
    • 0023263288 scopus 로고
    • Analysis of sequences from the extremely a + T-rich genome of Plasmodium falciparum
    • J.L. Weber Analysis of sequences from the extremely A + T-rich genome of Plasmodium falciparum Gene 52 1 1987 103 109
    • (1987) Gene , vol.52 , Issue.1 , pp. 103-109
    • Weber, J.L.1
  • 30
    • 0033434102 scopus 로고    scopus 로고
    • PCR-based gene synthesis as an efficient approach for expression of the a + T-rich malaria genome
    • C. Withers-Martinez, E.P. Carpenter, and F. Hackett PCR-based gene synthesis as an efficient approach for expression of the A + T-rich malaria genome Protein Eng 12 12 1999 1113 1120
    • (1999) Protein Eng , vol.12 , Issue.12 , pp. 1113-1120
    • Withers-Martinez, C.1    Carpenter, E.P.2    Hackett, F.3
  • 31
    • 0024806949 scopus 로고
    • Computer prediction of RNA structure
    • M. Zuker Computer prediction of RNA structure Meth Enzymol 180 1989 262 288
    • (1989) Meth Enzymol , vol.180 , pp. 262-288
    • Zuker, M.1
  • 32
    • 0031259782 scopus 로고    scopus 로고
    • Optimized gene synthesis, high level expression, isotopic enrichment, and refolding of human interleukin-5
    • D.V. Mehta, R.J. DiGate, D.L. Banville, and R.D. Guiles Optimized gene synthesis, high level expression, isotopic enrichment, and refolding of human interleukin-5 Protein Expr Purif 11 1 1997 86 94
    • (1997) Protein Expr Purif , vol.11 , Issue.1 , pp. 86-94
    • Mehta, D.V.1    Digate, R.J.2    Banville, D.L.3    Guiles, R.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.