Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 76, Issue 9, 2005, Pages 1249-1254

  McCabe, D J H ^a,b,c   Harrison, P ^c,d   Mackie, I J ^c   Sidhu, P S ^b   Purdy, G ^c   Lawrie, A S ^c   Watt, H ^b   Machin, S J ^c   Brown, M M ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID PLUS DIPYRIDAMOLE; AZAPROPAZONE; CD63 ANTIGEN; CLOPIDOGREL; DALTEPARIN; PADGEM PROTEIN; WARFARIN;

ACUTE DISEASE; ARTICLE; CARDIOVASCULAR RISK; CAROTID ARTERY OBSTRUCTION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CONVALESCENCE; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; HUMAN; LEUKOCYTE; LEUKOCYTOSIS; LYMPHOCYTE; MALE; MONOCYTE; MONOTHERAPY; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; STROKE; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTOSIS; TREATMENT OUTCOME;

EID: 23944472866     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.2004.051003     Document Type: Article

References (23)

1. The European Carotid Surgery Trialists' Collaborative Group. Risk of stroke in the distribution of an asymptomatic carotid artery. Lancet 1995;345:209-12.
2. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. Endarterectomy for asymptomatic carotid artery stenosis. JAMA 1995;273:1421-8.
3. North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 1991;325:445-53.
4. Golledge J, Greenhalgh RM, Davies AH. The symptomatic carotid plaque. Stroke 2000;31:774-81.
5. Cha JK, Jeong MH, Jang JY, et al. Serial measurement of surface expressions of CD63, P-selectin and CD40 ligand on platelets in atherosclerotic ischaemic stroke. A possible role of CD40 ligand on platelets in atherosclerotic ischaemic stroke. Cerebrovasc Dis 2003;16:376-82.
6. Moneta GL, Edwards JM, Chitwood RW, et al. Correlation of North American Symptomatic Carotid Endarterectomy Trial (NASCET) angiographic definition of 70% to 99% internal carotid artery stenosis with duplex scanning. J Vasc Surg 1993;17:152-7.
7. Shattil SJ, Cunningham M, Hoxie JA. Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood 1987;70:307-15.
8. Joseph JE, Harrison P, Mackie IJ, et al. Increased circulating platelet-leucocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis. Br J Haematol 2001;115:451-9.
9. McCabe DJ, Harrison P, Mackie IJ, et al. Platelet degranulation and monocyte-platelet complex formation are increased in the acute and convalescent phases after ischaemic stroke or transient ischaemic attack. Br J Haematol 2004;125:777-87.
10. Michelson AD. Flow cytometry: a clinical test of platelet function. Blood 1996;87:4925-36.
11. Abrams C, Shattil SJ. Immunological detection of activated platelets in clinical disorders. Thromb Haemost 1991;65:467-73.
12. Grau AJ, Ruf A, Vogt A, et al. Increased fraction of circulating activated platelets in acute and previous cerebrovascular ischemia. Thromb Haemost 1998;80:298-301.
13. Israels SJ, Gerrard JM, Jacques YV, et al. Platelet dense granule membranes contain both granulophysin and P-selectin (GMP-140). Blood 1992;80:143-52.
14. de Bruijne-Admiraal LG, Modderman PW, Von dem Borne AEGKr, et al. P-selectin mediates Ca(2+)-dependent adhesion of activated platelets to many different types of leucocytes: detection by flow cytometry. Blood 1992;80:134-42.
15. Numminen H, Hillbom M, Juvela S. Platelets, alcohol consumption, and onset of brain infarction. J Neurol Neurosurg Psychiatry 1996;61:376-80.
16. O'Malley T, Langhorne P, Elton RA, et al. Platelet size in stroke patients. Stroke 1995;26:995-9.
17. Butterworth RJ, Bath PMW. The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets 1998;9:359-64.
18. Michelson AD, Barnard MR, Krueger LA, et al. Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation 2001;104:1533-7.
19. Furman MI, Barnard MR, Krueger LA, et al. Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction. J Am Coll Cardiol 2001;38:1002-6.
20. Akopov SE, Simonian NA, Grigorian GS. Dynamics of polymorphonuclear leucocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage. Stroke 1996;27:1739-43.
21. Li N, Hu H, Lindqvist M, et al. Platelet-leucocyte cross talk in whole blood. Arterioscler Thromb Vasc Biol 2000;20:2702-8.
22. Mendelsohn ME, Loscalzo J. Role of platelets in cholesteryl ester formation by U-937 cells. J Clin Invest 1988;81:62-8.
23. Celi A, Pellegrini G, Lorenzet R, et al. P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci U S A 1994;91:8767-71.