Effect of ethane-1-hydroxy-1,1-bisphosphonate (EHBP) on endochondral ossification lesions induced by a lethal oral dose of uranyl nitrate

Archives of Toxicology

Volumn 79, Issue 8, 2005, Pages 475-481

  Bozal, C B ^a   Martinez, A B ^b   Cabrini, R L ^c   Ubios, A M ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^c DEPARTAMENTO DE FÍSICA   (Argentina)

Author keywords

Bisodic etidronate; Endochondral ossification; Growth cartilage; Oral uranium; Uranium exposure

Indexed keywords

ETIDRONIC ACID; URANYL NITRATE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE; CONTROLLED STUDY; DRUG EFFECT; ENCHONDRAL OSSIFICATION; FEMUR; HISTOPATHOLOGY; LETHALITY; MALE; METAPHYSIS; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; CHONDROGENESIS; DIPHOSPHONATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMUR; GROWTH PLATE; INJECTIONS, SUBCUTANEOUS; LONGEVITY; MALE; MICE; MICE, INBRED BALB C; OSTEOGENESIS; URANYL NITRATE;

ANIMALIA;

EID: 23944467825     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-005-0649-5     Document Type: Article

References (32)

1. Adams N, Spoor NL (1974) Kidney and bone retention functions in the human metabolism of uranium. Phys Med Biol 19:460-471
2. Au WW, Lane RG, Legator MS, Whorton EB, Wilkinson GS, Gabehart GJ (1995) Biomarker monitoring of a population residing near uranium mining activities. Environ Health Perspect 103:466-470
3. Cabrini RL, Guglielmotti MB, Ubios AM (1984) Prevention of the toxic effect of uranium on bone formation by tetracycline. Acta Odont Latinoam 1:61-63
4. Cothern CR, Lappenbusch WL (1983) Occurrence of uranium in drinking water in the US. Health Phys 45:89-99
5. Díaz Sylvester PL, López R, Ubios AM, Cabrini RL (2002) Exposure to subcutaneously implanted uranium dioxide impairs bone formation. Arch Environ Health 57:320-325
6. Domingo JL, Llobet JM, Tomás JM, Corbella J (1987) Acute toxicity of uranium in rats and mice. Bull Environ Contam Toxicol 39:168-174
7. Domingo JL, Ortega A, Llobet JM, Corbella J (1990) Effectiveness of chelation therapy with time after acute uranium intoxication. Fundam Appl Toxicol 14:88-95
8. Durbin PW, Kullgren B, Xu J, Raymond KN (1994) In vivo chelation of Am (III), Pu (IV), Np (V), and U (IV) in mice by Tren-(ME-3,2-HOPO). Radiat Prot Dosimetry 53:305-09
9. Durbin PW, Kullgren B, Xu J, Raymond KN (1997) New agents for in vivo chelation of uranium (VI): efficacy and toxicity in mice of multidentate catecholate and hydroxypyridonate ligands. Health Phys 72:865-879
10. Essien IO, Sandoval DN, Kuroda PK (1985) Deposition of excess amounts of natural U from the atmosphere. Health Phys 48:325-331
11. nd Edition. The Parthenon Publishing Group Ltd., England, London, PP 57-61 pp 67
12. Guglielmotti MB, Ubios AM, de Rey BM, Cabrini RL (1984) Effects of acute intoxication with uranyl nitrate on bone formation. Experientia 40:474-476
13. Guglielmotti MB, Ubios AM, Cabrini RL (1985) Alveolar wound healing alterations under uranyl nitrate intoxication. J Oral Pathol 14:565-572
14. Henge-Napoli MH, Archimbaud M, Ansoborlo E, Metivier H, Gourmelon P (1995) Efficacy of 3,4,3-LIHOPO for reducing the retention of uranium in rat after acute administration. Int J Radiat Biol 68:389-393
15. Hursh JB, Neuman WF, Toribara T, Wilson H, Waterhouse C (1969) Oral ingestion of uranium by man. Health Phys 17:619-621
16. Hussein EM (1994) Radioactivity of phosphate ore, superphosphate and phosphogypsum in Abu-Zaabal phosphate plant, Egypt. Health Phys 67:280-282
17. Lapham SC, Millard JB, Samet JM (1989) Health implications of radionuclide levels in cattle raised near U mining and milling facilities in Ambrosia Lake, New Mexico. Health Phys 56:327-340
18. Martínez AB, Cabrini RL, Ubios AM (2000) Orally administered ethane-1-hydroxy-1,1-bisphosphonate reduces the lethal effect of oral uranium poisoning. Health Phys 78:668-671
19. Martínez AB, Mandalunis PM, Bozal CB, Cabrini RL, Ubios AM (2003) Renal function in mice poisoned with oral uranium and treated with ethane-1-hydroxy-1,1-bisphosphonate (EHBP). Health Phys 85:343-347
20. Pujadas Bigi MM, Lemlich L, Mandalunis PM, Ubios AM (2003) Exposure to oral uranyl nitrate delays tooth eruption and development. Health Phys 84:163-169
21. de Rey BM, Lanfranchi HE, Cabrini RL (1983) Percutaneous absorption of uranium compounds. Environ Res 30:480-491
22. Ribera D, Labrot F, Tisnerat G, Narbonne JF (1996) Uranium in the environment: occurrence, transfer and biological effects. Rev Environ Contam Toxicol 146:53-89
23. Stradling GN, Gray SA, Moody JC, Ellender M (1991) Efficacy of tiron for enhancing the excretion of uranium from the rat. Hum Exp Toxicol 10:195-198
24. Sullivan MF, Ruemmler PS, Ryan JL, Buschbom RL (1986) Influence of oxidizing or reducing agents on gastrointestinal absorption of U, Pu, Am, Cm and Pm by rats. Health Phys 50:223-232
25. Ubios AM, Guglielmotti MB, Cabrini RL (1990) Ethane 1-hydroxy-1,1- diphosphonate (EHDP) counteracts the inhibitory effect of uranyl nitrate on bone formation. Arch Environ Health 45:376-377
26. Ubios AM, Guglielmotti MB, Steimetz T, Cabrini RL (1991) Uranium inhibits bone formation in physiologic alveolar bone modeling and remodeling. Environ Res 54:17-23
27. Ubios AM, Marzorati M, Cabrini RL (1992) Ultrastructural alterations of bone due to uranium intoxication. J Dent Res 71:973 (Abstract)
28. Ubios AM, Braun EM, Cabrini RL (1994) Lethality due to uranium poisoning is prevented by ethane-1-hydroxy-1,1-bisphosphonate (EHBP). Health Phys 66:540-544
29. Ubios AM, Braun EM, Cabrini RL (1998) Effect of bisphosphonates on abnormal mandibular growth in rats intoxicated with uranium. Health Phys 75:610-613
30. Weibel ER, Elias H (eds) (1967) Introduction to stereology and morphology. In: Quantitative methods in morphology. Springer-Verlag, Berlin Heidelberg New York, pp 3-19
31. Yamamoto T, Masuda K, Nukada K (1971) Studies on environmental contamination by uranium. 6. Uranium in total diet and human urine from non-occupationally exposed persons in Okayama Prefecture. J Radiat Res 13:5
32. Zamora ML, Tracy BL, Zielinski JM, Meyerhof DP, Moss MA (1998) Chronic ingestion of uranium in drinking water: a study of kidney bioeffects in humans. Toxicol Sci 43:68-77