Effective synthesis of enantiopure [1,2,3]triazolo[1,5-a]- and pyrazolo[1,5-a]-pyrrolo[2,1-c][1,4]benzodiazepines by diastereoselective intramolecular azide and nitrilimine cycloadditions

Synthesis

Volumn , Issue 13, 2005, Pages 2246-2252

  Broggini, Gianluigi ^a   De Marchi, Ivan ^a   Martinelli, Michela ^a,b   Paladino, Giuseppe ^b   Pilati, Tullio ^c   Terraneo, Alberto ^d  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c CNR   (Italy)

^d Chorisis SRL   (Italy)

Author keywords

Azides; Diastereoselectivity; Fused ring systems; Nitrilimines; Pyrrolo 2,1 c 1,4 benzodiazepines

Indexed keywords

CRYSTALLOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

AZIDES; DIASTEREOSELECTIVITY; FUSED-RING SYSTEMS; NITRILIMINES; PYRROLO[2,1-C][1,4] BENZODIAZEPINES;

ORGANIC COMPOUNDS;

10 CHLORO 3,3A,3B,4,5,6 HEXAHYDROPYRROLO[2,1 C][1,2,3]TRIAZOLO[1,5 A][1,4]BENZODIAZEPIN 8 ONE; 10 FLUORO 3,3A,3B,4,5,6 HEXAHYDROPYRROLO[2,1 C][1,2,3]TRIAZOLO[1,5 A][1,4]BENZODIAZEPIN 8 ONE; 2 CARBOMETHOXY 10 CHLORO 3,3A,3B,4,5,6 HEXAHYDROPYRROLO[2,1 C][1,2,3]PYRAZOLO[1,5 A][1,4]BENZODIAZEPIN 8 ONE; 2 CARBOMETHOXY 10 FLUORO 3,3A,3B,4,5,6 HEXAHYDROPYRROLO[2,1 C][1,2,3]PYRAZOLO[1,5 A][1,4]BENZODIAZEPIN 8 ONE; 2 CARBOMETHOXY 3,3A,3B,4,5,6 HEXAHYDROPYRROLO[2,1 C][1,2,3]PYRAZOLO[1,5 A][1,4]BENZODIAZEPIN 8 ONE; 3,3A,3B,4,5,6 HEXAHYDROPYRROLO[2,1 C][1,2,3]TRIAZOLO[1,5 A][1,4]BENZODIAZEPIN 8 ONE; BENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CYCLOADDITION; DIASTEREOISOMER; ENANTIOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOCHEMISTRY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

EID: 23944453990     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-869991     Document Type: Article

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