Neutrophil adherence to bladder microvascular endothelial cells following platelet-activating factor acetylhydrolase inhibition

Journal of Pharmacology and Experimental Therapeutics

Volumn 314, Issue 3, 2005, Pages 1241-1247

  Vinson, Suzanne M ^a   Rickard, Alice ^a   Ryerse, Jan S ^a   McHowat, Jane ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; 2 [N,N BIS(2 OLEOYLOXYETHYL)AMINE] 1 ETHANESULFONIC ACID; ARACHIDONYL TRIFLUOROMETHYL KETONE; BROMOENOL LACTONE; PADGEM PROTEIN; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PX 18; SULFONIC ACID DERIVATIVE; THROMBOCYTE ACTIVATING FACTOR; TRYPTASE; UNCLASSIFIED DRUG;

ARTICLE; BLADDER; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; INFLAMMATION; INTERSTITIAL CYSTITIS; LEUKOCYTE ADHERENCE; MAST CELL; METABOLITE; MICROVASCULATURE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ARACHIDONIC ACIDS; CELL ADHESION; CELLS, CULTURED; CYSTITIS; ENDOTHELIAL CELLS; ENZYME INHIBITORS; HUMANS; NEUTROPHILS; PHOSPHOLIPASES A; PHOSPHONIC ACIDS; PLATELET ACTIVATING FACTOR; URINARY BLADDER;

EID: 23944450910     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.105.085365     Document Type: Article

References (38)

1. Abraham E, Naum C, Bandi V, Gervich D, Lowry SF, Wunderink R, Schein RM, Macias W, Skerjanec S, Dmitrienko A, et al. (2003) Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure. Crit Care Med 31:718-728.
2. Ackermann EJ, Conde-Frieboes K, and Dennis EA (1995) Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem 270:445-450.
3. Balsinde J and Dennis EA (1996a) Bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse P388D1 macrophages. J Biol Chem 271:31937-31941.
4. Balsinde J and Dennis EA (1996b) Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages. J Biol Chem 271:6758-6765.
5. Bligh EG and Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Med Sci 37:911-917.
6. Buffington CA (2004) Comorbidity of interstitial cystitis with other unexplained clinical conditions. J Urol 172:1242-1248.
7. Farberman MM, deMello DE, Hoffmann JW, and Ryerse JS (2005) Morphologic changes in alveolar macrophages in response to UVEC-activated pulmonary type II epithelial cells. Tissue Cell 37:213-222.
8. Franson RC and Rosenthal MD (1997) PX-52, a novel inhibitor of 14 kDa secretory and 85 kDa cytosolic phospholipases A2. Adv Exp Med Biol 400A:365-373.
9. Franson RC, Rosenthal MD, and Regelson W (1991) Mechanism(s) of cytoprotective and anti-inflammatory activity of PGB1 oligomers: PGBx has potent antiphospholipase A2 and anti-oxidant activity. Prostaglandins Leukot Essent Fatty Acids 43:63-70.
10. Geng JG, Bevilacqua MP, Moore KL, McIntyre TM, Prescott SM, Kim JM, Bliss GA, Zimmerman GA, and McEver RP (1990) Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Nature (Lond) 343:757-760.
11. Henderson WR Jr, Lu J, Poole KM, Dietsch GN, and Chi EY (2000) Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model. J Immunol 164:3360-3367.
12. Huang Z, Liu S, Street I, Laliberté F, Abdullah K, Desmarais S, Wang Z, Kennedy B, Payette P, Riendeau D, et al. (1994) Methyl arachidonyl fluorophosphonate, a potent irreversible cPLA2 inhibitor, blocks the mobilization of arachidonic acid in human platelets and neutrophils. Mediat Inflamm 3:307-308.
13. Kell PJ, Creer MH, Crown KN, Wirsig K, and McHowat J (2003) Inhibition of platelet-activating factor (PAF) acetylhydrolase by methyl arachidonyl fluorophosphonate potentiates PAF synthesis in thrombin-stimulated human coronary artery endothelial cells. J Pharmacol Exp Ther 307:1163-1170.
14. Lefer AM and Lefer (1996) The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion. Cardiovasc Res 32:743-751.
15. Lio YC, Reynolds LJ, Balsinde J, and Dennis EA (1996) Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta 1302:55-60.
16. Lorant DE, Patel KD, McIntyre TM, McEver RP, Prescott SM, and Zimmerman GA (1991) Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils. J Cell Biol 115:223-234.
17. McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L, and Bainton DF (1989) GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Investig 84:92-99.
18. 2. Biochemistry 40:14921-14931.
19. 2 inhibitors as potential anti-inflammatory agents. Curr Pharm Design 11:1301-1312.
20. Nickel JC (2004) Interstitial cystitis: a chronic pelvic pain syndrome. Med Clin North Am 88:467-481, xii.
21. Prescott SM, McIntyre TM, Zimmerman GA, and Stafforini DM (2002) Sol Sherry lecture in thrombosis: molecular events in acute inflammation. Arterioscler Thromb Vasc Biol 22:727-733.
22. Rickard A, Portell C, Kell PJ, Vinson SM, and McHowat J (2004) Protease activated receptor stimulation activates a calcium-independent phospholipase A2 in bladder microvascular endothelial cells. Am J Physiol Renal Physiol 288:F714-F721.
23. Rollin S, Lemieux C, Maliba R, Favier J, Villeneuve LR, Allen BG, Soker S, Bazan NG, Merhi Y, and Sirois MG (2004) VEGF-mediated endothelial P-selectin translocation: role of VEGF receptors and endogenous PAF synthesis. Blood 103:3789-3797.
24. Ryerse JS (1989) Isolation and characterization of Drosophila gap junctions. Cell Tiss Res 256:7-16.
25. Scott KF, Graham GG, and Bryant KJ (2003) Secreted phospholipase A2 enzymes as therapeutic targets. Expert Opin Ther Targets 7:427-440.
26. Selo-Ojeme DO and Onwude JL (2004) Interstitial cystitis. J Obstet Gynaecol 24:216-225.
27. 2 enzymes: classification and characterization. Biochim Biophys Acta 1488:1-19.
28. Stafforini DM, McIntyre TM, Zimmerman GA, and Prescott SM (1997) Platelet-activating factor acetylhydrolases. J Biol Chem 272:17895-17898.
29. Stafforini DM, McIntyre TM, Zimmerman GA, and Prescott SM (2003) Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. Crit Rev Clin Lab Sci 40:643-672.
30. Stafforini DM, Satoh K, Atkinson DL, Tjoelker LW, Eberhardt C, Yoshida H, Imaizumi T, Takamatsu S, Zimmerman GA, McIntyre TM, et al. (1996) Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase. J Clin Investig 97:2784-2791.
31. Theoharides TC, Kempuraj D, and Sant GR (2001) Mast cell involvement in interstitial cystitis: a review of human and experimental evidence. Urology 57:47-55.
32. Tjoelker LW, Eberhardt C, Unger J, Trong HL, Zimmerman GA, McIntyre TM, Stafforini DM, Prescott SM, and Gray PW (1995) Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad. J Biol Chem 270:25481-25487.
33. Tjoelker LW and Stafforini DM (2000) Platelet-activating factor acetylhydrolases in health and disease. Biochim Biophys Acta 1488:102-123.
34. Tykka HT, Vaittinen EJ, Mahlberg KL, Railo JE, Pantzar PJ, Sarna S, and Tallberg T (1985) A randomized double-blind study using CaNa2EDTA, a phospholipase A2 inhibitor, in the management of human acute pancreatitis. Scand J Gastroenterol 20:5-12.
35. Warren JW and Keay SK (2002) Interstitial cystitis. Curr Opin Urol 12:69-74.
36. Zeng S, Yi FX, and Guo ZG (1999) Platelet activating factor-induced P-selectin expression in platelets and its related signal transduction. Zhongguo Yao Li Xue Bao 20:948-950.
37. Zimmerman GA, Prescott SM, and McIntyre TM (1992) Endothelial cell interactions with granulocytes: tethering and signaling molecules. Immunol Today 13:93-100.
38. Zupan LA, Weiss RH, Hazen SL, Parnas BL, Aston KW, Lennon PJ, Getman DP, and Gross RW (1993) Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2. J Med Chem 36:95-100.