Interleukin-1α, 6 regulate the secretion of vascular endothelial growth factor A, C in pancreatic cancer

Hepatobiliary and Pancreatic Diseases International

Volumn 4, Issue 3, 2005, Pages 460-463

  Tang, Rui Feng ^a,b   Wang, Shu Xia ^a,b   Zhang, Feng Rui ^a,b   Peng, Li ^a,b   Wang, Shun Xiang ^a,b   Xiao, Yan ^a,b   Zhang, Meng ^a,b  

^a Hebei Medical University ^*

^b HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Cytokine; Interleukin 1 ; Interleukin 6; Pancreatic cancer; Vascular endothelial growth factor; VEGF C

Indexed keywords

INTERLEUKIN 1ALPHA; INTERLEUKIN 6; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; INTERLEUKIN 1; MESSENGER RNA; VASCULAR ENDOTHELIAL GROWTH FACTOR A, HUMAN;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NORTHERN BLOTTING; PANCREAS CANCER; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; GENETICS; METABOLISM; PANCREAS TUMOR; SECRETION; TUMOR CELL LINE;

BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE, TUMOR; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 23944450679     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Yamamoto M, Ohashi O, Saitoh Y. Studies on TNM classification of carcinoma of the exocrine pancreas. Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy] [in Japanese] 1998;25:143-149 .
2. Folkmann J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature (Med) 1995;1:27-31.
3. Ferrara N. Vascular endothelial growth factor: molecular and biological aspects. In: Claesson-Welsh L, eds. Vascular growth factors and angiogenesis. Berlin; Springer-Verlag Press; 1999:1-30.
4. Eiksson U, Alitalo K. Structure, expression and receptor-binding properties of novel vascular endothelial growth factor. In: Claesson-Welsh L, eds. Vascular growth factors and angiogenesis. Berlin: Springer Verlag Press; 1999:41-57.
5. Jukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 1996;15: 290-298.
6. Ogawa S, Oku A, Sawano A, Yamaguchi S, Yazaki Y, Shibuya M. A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/ Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain. J Bio Chem 1998;273;31273-31282.
7. Yonemura Y, Endo Y, Fujita H, Fushida S, Ninomiya I, Bandou E, et al. Role of vascular endothelial growth factor-C expression in the development of lymph node metastasis in gastric cancer. Clin Cancer Res 1999;5:1823-1829.
8. Salven P, Hattori K, Heissing B, Rafii S. Interleukin-1 alpha promotes angiogenesis in vivo VEGF-VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion. FASEB J 2002;16:1471-1473.
9. Cohen T, Nahari D, Cerem LW, Neufeld G, Levi BZ. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem 1996;271:736-741.
10. Akagi Y, Liu W, Xie K, Zebrowski B, Shaheen RM, Ellis LM. Regulation of vascular endothelial growth factor expression in human colon cancer by interleukin-1beta. Br J Cancer 1999;80:1506-1511.
11. Huang SP, Wu MS, Shun CT, Wang HP, Lin MT, Kuo ML, et al. Interleukin-6 increases vascular endothelial growth factor and angiogenesis in gastric carcinoma. J Biomed Sci 2004;11:517-527.
12. Wei LH, Kuo ML, Chen CA, Chou CH, Lai KB, Lee CN, et al. Interleukin-6 promotes cervical tumor growth by VEGF dependent angiogenesis via a STAT3 pathway. Oncogene 2003;22:1517-1527.
13. Ristimaki A, Narko K, Enholm B, Joukov V, Ajitalo K. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. J Biol Chem 1998;273:8413-8418.
14. Tang RF, Itakura J, Aikawa T, Matsuda K, Fujii H, Korc M, et al. Overexpression of lymphangiogenic growth factor VEGF-C in human pancreatic cancer. Pancreas 2001;22;285-292.
15. Tang RF, Peng Li, Wang SX, Zhang FR, Wang SX, Xiao Y, et al. An analysis on coexpression of vascular endothelial growth factor-A, C in human pancreatic cancer. Zhonghua Shi Yan Wai Ke Za Zhi 2002;19:S11-12.
16. Gao FZ, Zheng ZL, Gai BD, Zhu LY, Zhao WG. Study on new vessels density and expression of vascular endothelial growth factor in pancreatic cancer. Zhonghua Shi Yan Wai Ke Za Zhi 2001;18:119.
17. Kellokumpu-Lehtinen P, Talpaz M, Harris D, Van Q, KurzrouK R, Estrov Z. Leukemia-inhibitory factor stimulates breast, kidney and prostate cancer cell proliferation by paracrine and autocrine pathways. Int J Cancer 1996;66:515-519.
18. Edwards DR, Murphy G. Cancer. Proteases-invasion and more. Nature 1998;394:527-528.
19. Xing YF, Xiao YJ, Zhang QJ, Lu GC. The effect of IL-6 on the growth of prostate cancer cells in vitro and its modulation. Zhonghua Shi Yan Wai Ke Za Zhi 1999;16:502-503.