Viability of a capsule- and lipopolysaccharide-deficient mutant of Neisseria meningitidis

Infection and Immunity

Volumn 73, Issue 9, 2005, Pages 6194-6197

  Bos, Martine P ^a   Tommassen, Jan ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BACTERIUM LIPOPOLYSACCHARIDE;

ARTICLE; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BACTERIUM MUTANT; GENE CLUSTER; GENE DELETION; GENE EXPRESSION; GENE LOCUS; NEISSERIA MENINGITIDIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ACYLTRANSFERASES; BACTERIAL CAPSULES; GENE DELETION; GENETIC MARKERS; LIPOPOLYSACCHARIDES; MULTIGENE FAMILY; NEISSERIA MENINGITIDIS;

EID: 23944444352     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.9.6194-6197.2005     Document Type: Article

References (18)

1. Albiger, B., L. Johansson, and A. B. Jonsson. 2003. Lipooligosaccharide- deficient Neisseria meningitidis shows altered pilus-associated characteristics. Infect. Immun. 71:155-162.
2. Bogdan, J. A., C. A. S. A. Minetti, and M. S. Blake. 2002. A one-step method for genetic transformation of non-piliated Neisseria meningitidis. J. Microbiol. Methods 49:97-101.
3. Bos, M. P., B. Tefsen, J. Geurtsen, and J. Tommassen. 2004. Identification of an outer membrane protein required for the transport of lipopolysaccharide to the bacterial cell surface. Proc. Natl. Acad. Sci. USA 101:9417-9422.
4. Frosch, M., and A. Muller. 1993. Phospholipid substitution of capsular polysaccharides and mechanism of capsule formation in Neisseria meningitidis. Mol. Microbiol. 8:483-493.
5. Frosch, M., E. Schultz, E. Glenn-Calvo, and T. F. Meyer. 1990. Generation of capsule-deficient Neisseria meningitidis strains by homologous recombination. Mol. Microbiol. 4:1215-1218.
6. Galloway, S. M., and C. R. H. Raetz. 1990. A mutant of Escherichia coli defective in the first step of endotoxin biosynthesis. J. Biol. Chem. 265:6394-6402.
7. Hammerschmidt, S., C. Birkholtz, U. Zaehringer, B. D. Robertson, J. van Putten, O. Ebeling, and M. Frosch. 1994. Contribution of genes from the capsule gene complex (cps) to lipooligosaccharide biosynthesis and serum resistance in Neisseria meningitidis. Mol. Microbiol. 11:885-896.
8. Hayrinen, J., D. Bitter-Suermann, and J. Finne. 1989. Interaction of meningococcal group B monoclonal antibody and its Fab fragment with alpha 2-8-linked sialic acid polymers: requirement of a long oligosaccharide segment for binding. Mol. Immunol. 26:523-529.
9. Kahler, C. M., and D. S. Stephens. 1998. Genetic basis for biosynthesis, structure and function of meningococcal lipooligosaccharide (endotoxin). Crit. Rev. Microbiol. 24:281-334.
10. Parrillo, J. E. 1993. Pathogenic mechanisms of septic shock. N. Engl. J. Med. 328:1471-1477.
11. Raetz, C. R. H., and C. Whitfield. 2002. Lipopolysaccharide endotoxins. Annu. Rev. Biochem. 71:635-700.
12. Steeghs, L., H. de Cock, E. Evers, B. Zomer, J. Tommassen, and P. van der Ley. 2001. Outer membrane composition of a lipopolysaccharide-deficient Neisseria meningitidis mutant. EMBO J. 20:6937-6945.
13. Steeghs, L., R. den Hartog, A. den Boer, B. Zomer, P. Roholl, and P. van der Ley. 1998. Meningitis bacterium is viable without endotoxin. Nature 392:449-450.
14. Tettelin, H., N. J. Saunders, J. Heidelberg, A. C. Jeffries, K. E. Nelson, J. A. Eisen, K. A. Ketchum, D. W. Hood, J. F. Peden, R. J. Dodson, W. C. Nelson, M. L. Gwinn, R. DeBoy, J. D. Peterson, E. K. Hickey, D. H. Haft, S. L. Salzberg, O. White, R. D. Fleischmann, B. A. Dougherty, T. Mason, A. Ciecko, D. S. Parksey, E. Blair, H. Cittone, E. B. Clark, M. D. Cotton, T. R. Utterback, H. Khouri, H. Qin, J. Vamathevan, J. Gill, V. Scarlato, V. Masignani, M. Pizza, G. Grandi, L. Sun, H. O. Smith, C. M. Fraser, E. R. Moxon, R. Rappuoli, and J. C. Venter. 2000. Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science 287:1809-1815.
15. Tzeng, Y. L., A. K. Datta, C. A. Strole, M. A. Lobritz, R. W. Carlson, and D. S. Stephens. 2005. Translocation and surface expression of lipidated serogroup B capsular polysaccharide in Neisseria meningitidis. Infect. Immun. 73:1491-1505.
16. Tzeng, Y. L., C. Noble, and D. S. Stephens. 2003. Genetic basis for biosynthesis of the (α1-4)-linked N-acetyl-D-glucosamine 1-phosphate capsule of Neisseria meningitidis serogroup X. Infect. Immun. 71:6712-6720.
17. Uronen-Hansson, H., L. Steeghs, J. Allen, G. L. Dixon, M. Osman, P. van der Ley, S. Y. Wong, R. Callard, and N. Klein. 2004. Human dendritic cell activation by Neisseria meningitidis: phagocytosis depends on expression of lipooligosaccharide (LOS) by the bacteria and is required for optimal cytokine production. Cell. Microbiol. 6:625-637.
18. Vogel, U., and M. Frosch. 2002. The genus Neisseria: population structure, genome plasticity, and evolution of pathogenicity. Curr. Top. Microbiol. Immunol. 264:23-45.