Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8- nitroquinazolines as EGFR signaling-targeted inhibitors

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 19, 2005, Pages 5613-5622

  Jin, Yi ^a   Li, Hui Yuan ^a   Lin, Li Ping ^a   Tan, Jinzhi ^a   Ding, Jian ^a   Luo, Xiaomin ^a   Long, Ya Qiu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Breast cancer; Cellular signaling; EGFR inhibitor; ErbB 2; Quinazolines

Indexed keywords

5 (4 METHOXY)ANILINO 4 HYDROXY 8 NITROQUINAZOLINE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ASSAY; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MOLECULAR MODEL; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23944442253     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.05.045     Document Type: Article

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