Relation of postmortem blood alcohol and drug concentrations in fatal poisonings involving amitriptyline, propoxyphene and promazine

Human and Experimental Toxicology

Volumn 24, Issue 8, 2005, Pages 389-396

  Koski, Anna ^a   Vuori, E ^a   Ojanpera I ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Alcohol; Drugs; Forensic; Interaction; Postmortem

Indexed keywords

ALCOHOL; AMITRIPTYLINE; BENZODIAZEPINE DERIVATIVE; DEXTROPROPOXYPHENE; PROMAZINE;

ALCOHOL BLOOD LEVEL; AREA UNDER THE CURVE; ARTICLE; AUTOPSY; CONCENTRATION RESPONSE; DRUG ALCOHOL INTERACTION; DRUG FATALITY; DRUG OVERDOSE; FATALITY; FEMALE; HUMAN; HUMAN TISSUE; INTOXICATION; LETHAL DOSE; MALE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

AMITRIPTYLINE; DRUG INTERACTIONS; ETHANOL; FINLAND; FORENSIC MEDICINE; HUMANS; POISONING; POSTMORTEM CHANGES; PROMAZINE; PROPOXYPHENE;

EID: 23944432114     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327105ht542oa     Document Type: Article

References (22)

1. Baselt RC. Drug effects on psychomotor performance. Foster City: Biomedical Publications, 2001.
2. Okamoto M, Rao SN, Aaronson LM, Walewski JL. Ethanol drug interaction with chlordiazepoxide and pentobarbital. Alcohol Clin Exp Res 1385; 9: 516-21.
3. King LA. Effect of ethanol on drug levels in blood in fatal cases. Med Sci Law 1982; 22: 232-34.
4. Poikolainen K. Estimated lethal ethanol concentrations in relation to age, aspiration and drugs. Alcohol Clin Exp Res 1984; 8: 223-25.
5. Stead AH, Moffat AC. Quantification of the interaction between barbiturates and alcohol and interpretation of fatal blood concentrations. Hum Toxicol 1983; 2: 5-14.
6. Dinovo EC, Gottschalk LA, McGuire FL, Birch H, Heiser JF. Analysis of results of toxicological examinations performed by coroners' or medical examiners' laboratories in 2000 drug-involved deaths in nine major U.S. cities. Clin Chem 1976; 22: 847-50.
7. Whittington RM. Dextropropoxyphene deaths: coroner's report. Hum Toxicol 1984; 3: 175S-85S.
8. Vuori E, Ojanperä I, Nokua J, Ojansivu RL. Fatal poisonings in Finland during 2000 and 2001 based on forensic toxicological investigations. Suomen Lääkärilehti 2003; 58: 3403-407.
9. Koski A, Ojanperä I, Vuori E. Alcohol and benzodiazepines in fatal poisonings. Alcohol Clin Exp Res 2002; 26: 956-59.
10. Koski A, Ojanperä I, Vuori E. Interaction of alcohol and drugs in fatal poisonings. Hum Exp Toxicol 2003; 22: 281-87.
11. Statistical yearbook of Finland 1996-2003. Helsinki: Statistics Finland, 1996-2003.
12. Rasanen I, Ojanperä I, Vartiovaara J, Vuori E, Sunila P. The advantage of dual-column approach and retention indices combined with refined reporting in gas chromatographic drug screening. J High Res Chromatogr 1996; 19: 313-21.
13. Rasanen I, Ojanperä I, Vuori E. Quantitative screening for benzodiazepines in blood by dual-column gas chromatography and comparison of the results with urine immunoassay. J Anal Toxicol 2000; 24: 46-53.
14. Jones AW, Schuberth J. Computer-aided headspace gas chromatography applied to blood-alcohol analysis: importance of online process control. J Forensic Sci 1989; 34: 1116-27.
15. Uges DRA. Therapeutic and toxic drug concentrations. Bull Int Assoc Forensic Toxicol 1996; 26: 1-34.
16. Winek CL, Wahba WW, Winek CL Jr. Drug and chemical blood level data 2001. Forensic Sci Int 2001; 122: 107-23.
17. Stead AH, Moffat AC. A collection of therapeutic, toxic and fatal blood drug concentrations in man. Hum Toxicol 1983; 2: 437-64.
18. Osselton MD. Toxicological tables: a compendium of pharmacological, therapeutic and toxicological data on 136 drugs and chemicals in humans. Bull Int Assoc Forensic Toxicol 1983; 17: 16-33.
19. King LA. Synergistic effect of benzodiazepines in fatal amitriptyline poisonings. Lancet 1982; 2: 982-83.
20. Druid H, Holmgren P. A compilation of fatal and control concentrations of drugs in postmortem femoral blood. J Forensic Sci 1997; 42: 79-87.
21. The international statistical classification of diseases and related health problems, tenth revision. Geneva: World Health Organization, 1992.
22. Finnish statistics on medicines 1995-2002. Helsinki: National Agency for Medicines and Social Insurance Institution, 1996-2003.