Structural changes in calcium-binding allergens: Use of circular dichroism to study binding characteristics

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 60, Issue 9, 2005, Pages 1208-1211

  Hebenstreit, D ^a   Ferreira, Fatima ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Affinity; Allergens; Bet v 4; Calcium; Circular dichroism

Indexed keywords

ALLERGEN; BET V 4 PROTEIN; CALCIUM BINDING PROTEIN; CALCIUM ION; POLLEN ANTIGEN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ALLERGENICITY; ANTIGEN ANTIBODY COMPLEX; ANTIGEN STRUCTURE; ARTICLE; CALCIUM BINDING; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STOICHIOMETRY; TITRIMETRY;

ALLERGENS; BINDING SITES; CALCIUM; CALCIUM-BINDING PROTEINS; CIRCULAR DICHROISM; PLANT PROTEINS; POLLEN;

EID: 23844555199     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2005.00907.x     Document Type: Article

References (15)

1. Valenta R, Hayek B, Seiberler S, Bugajska-Schretter A, Niederberger V, Twardosz A et al. Calcium-binding allergens: from plants to man. Int Arch Allergy Immunol 1998;117:160-166.
2. Lewit-Bentley A, Rety S. EF-hand calcium-binding proteins. Curr Opin Struct Biol 2000;10:637-643.
3. Aas K, Jebsen JW. Studies of hypersensitivity to fish. Partial purification and crystallization of a major allergenic component of cod. Int Arch Allergy Appl Immunol 1967;32:1-20.
4. Kretsinger RH, Nockolds CE. Carp muscle calcium-binding protein. II. Structure determination and general description. J Biol Chem 1973;248:3313-3326.
5. Engel E, Richter K, Obermeyer G, Briza P, Kungl AJ, Simon B et al. Immunological and biological properties of Bet v 4, a novel birch pollen allergen with two EF-hand calcium-binding domains. J Biol Chem; 1997;272:28630-28637.
6. Hayek B, Vangelista L, Pastore A, Sperr WR, Valent P, Vrtala S et al. Molecular and immunologic characterization of a highly cross-reactive two EF-hand calcium-binding alder pollen allergen, Aln g 4: structural basis for calcium-modulated IgE recognition. J Immunol 1998;161:7031-7039.
7. Niederberger V, Hayek B, Vrtala S, Laffer S, Twardosz A, Vangelista L et al. Calcium-dependent immunoglobulin E recognition of the apo- and calcium-bound form of a cross-reactive two EF-hand timothy grass pollen allergen, Ph1 p 7. Faseb J 1999;13:843-856.
8. Ledesma A, Gonzalez E, Pascual CY, Quiralte J, Villalba M, Rodriguez R. Are Ca2+-binding motifs involved in the immunoglobulin E-binding of allergens? Olive pollen allergens as model of study. Clin Exp Allergy 2002;32:1476-1483.
9. Twardosz A, Hayek B, Seiberler S, Vangelista L, Elfman L, Gronlund H et al. Molecular characterization, expression in Escherichia coli, and epitope analysis of a two EF-hand calcium-binding birch pollen allergen, Bet v 4. Biochem Biophys Res Commun 1997;239:197-204.
10. Berggard T, Miron S, Onnerfjord P, Thulin E, Akerfeldt KS, Enghild JJ et al. Calbindin D28k exhibits properties characteristic of a Ca2+ sensor. J Biol Chem 2002;277:16662-16672.
11. Dell'Angelica EC, Schleicher CH, Santome JA. Primary structure and binding properties of calgranulin C, a novel S100-like calcium-binding protein from pig granulocytes. J Biol Chem 1994;269:28929-28936.
12. Kakalis LT, Kennedy M, Sikkink R, Rusnak F, Armitage IM. Characterization of the calcium-binding sites of calcineurin B. FEBS Lett 1995;362:55-58.
13. Di Pietro SM, Santome JA. Structural and biochemical characterization of cal-hepatin, an S100-like calcium-binding protein from the liver of lungfish (Lepidosiren paradoxa). Eur J Biochem 2002;269:3433-3441.
14. Haiech J, Klee CB, Demaille JG. Effects of cations on affinity of calmodulin for calcium: ordered binding of calcium ions allows the specific activation of calmodulin-stimulated enzymes. Biochemistry 1981;20:3890-3897.
15. Haiech J, Derancourt J, Pechere JF, Demaille JG. Magnesium and calcium binding to parvalbumins: evidence for differences between parvalbumins and an explanation of their relaxing function. Biochemistry 1979;18:2752-2758.