The contractile effects of several substituted short analogues of porcine galanin in isolated rat jejunal and colonic smooth muscle strips

Pharmacological Research

Volumn 52, Issue 4, 2005, Pages 283-289

  Umer, A ^a   Lugowska H ^a   Sein Anand, J ^a   Rekowski, P ^b   Ruczynski J ^b   Petrusewicz, J ^a   Korolkiewicz, R P ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF GDA SK   (Poland)

Author keywords

Galanin; Rat; Smooth muscle

Indexed keywords

GALANIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COLON; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; JEJUNUM; MOLECULAR DYNAMICS; MUSCLE CONTRACTION; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE;

ANIMALS; COLON; FEMALE; GALANIN; JEJUNUM; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 23844532349     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2005.05.001     Document Type: Article

References (27)

1. K. Tatemoto, A. Rokaeus, H. Jornvall, T.J. McDonald, and V. Mutt Galanin a novel biologically active peptide from porcine intestine FEBS Lett 164 1983 124 128
2. K. Bedecs, M. Berthold, and T. Bartfai Galanin-10 years with a neuroendocrine peptide Int J Biochem Cell Biol 27 1995 337 349
3. M.E. Vrontakis Galan: a biologically active F peptide Curr Drug Target F CNS. Neurol Disord 1 2002 531 541
4. A.L. Gundlach Galanin/GALP and galanin receptors: role in central control of feeding, body weight/obesity and reproduction? Eur J Pharmacol 440 2002 255 268
5. T. Bartfai Galanin: a neuropeptide with important central nervous system actions F.E. Bloom D.J. Kupfer Psychopharmacology: the fourth generation of progress 1995 Raven Press Ltd. New York 563 571
6. - secretion Am J Physiol 276 1999 G64 G72
7. J.E. Fox, B. Brooks, T.J. McDonald, W. Barnett, F. Kostolanska, and C. Yanaihara Actions of galanin fragments on rat, guinea-pig, and canine intestinal motility Peptides 9 1988 1183 1189
8. H. Harling, H. Gregersen, T.N. Rasmussen, S.S. Poulsen, J.J. Holst, and S.L. Jenson Galanin: distribution and effect on contractile activity and release of vasoactive intestinal polypeptide from the isolated perfused porcine ileum Digestion 47 1990 191 199
9. S. Katsoulis, A. Clemens, C. Morys-Wortmann, H. Schworer, H. Schaube, and H.J. Klomp Human galanin modulates human colonic motility in vitro. Characterization of structural requirements Scand J Gastroenterol 31 1996 446 451
10. S. Katsoulis, W.E. Schmidt, H. Schwörer, and W. Creutzfeldt Effects of galanin, its analogues and fragments on rat isolated fundus strips Br J Pharmacol 101 1990 297 300
11. R.P. Korolkiewicz, Z. Konstanski, P. Rekowski, J. Ruczynski, A. Szyk, and M. Grzybowska Actions of several substituted short analogues of porcine galanin on isolated rat fundus strips: a structure-activity relationship J Physiol Pharmacol 52 2001 127 136
12. J.R. Vane A sensitive method for assay of 5-hydroxytryptamine Br J Pharmacol 12 1957 344 349
13. J. Ruczyński, A. Szyk, Z. Konstański, R. Korolkiewicz, and P. Rekowski Galanin and its analogues modified in position 14: chemical synthesis and biological activity Pol J Chem 74 2000 1375 1384
14. R.J. Tallarida, and R.B. Murray Manual of pharmacologic calculations with computer programs 2nd ed. 1986 Springer-Verlag New York
15. R.B. Barlow Biodata handling with microcomputers. Programs written in BASIC for handling biological, biochemical, pharmacological and physicochemical results-with a commentary on the calculations involved 1983 Elsevier Science Publishers B.V. Amsterdam
16. W.J. Rossowski, S. Zacharia, N.-Y. Jiang, Z. Mungan, M. Mills, and A. Ertan Galanin: structure-dependent effect on pancreatic amylase secretion and jejunal strip contraction Eur J Pharmacol 240 1993 259 267
17. B. Amiranoff, A.-M. Lorimer, N. Yanaihara, and M. Laburthe Structural requirements for galanin action in the pancreatic beta cell line Rin m5F Eur J Pharmacol 163 1989 205 207
18. E. Ekblad, R. Håkanson, F. Sundler, and C. Wahlstedt Galanin: neuromodulatory and direct contractile effects on smooth muscle preparations Br J Pharmacol 86 1985 241 246
19. A. Kuwahara, T. Ozaki, and N. Yanaihara Structural requirements for galanin action in the guinea-pig leum Regul Pept 29 1990 23 29
20. I. Lagny-Pourmir, A. Lorinet, N. Yanaihara, and M. Laburthe Structural requirements for galanin action in the pancreatic β-cell line Rin m5F Eur J Pharmacol 163 1989 205 207
21. 8]-scyliorhynin-I: structure dependent effects on the rat isolated gastric fundus Pharmacol Res 35 1997 7 16
22. N. Yanaihara, T. Mochizuki, N. Takatsuka, K. Iguchi, K. Sato, and H. Kakayuma Galanin analogues: agonist and antagonist Regul Pept 46 1993 93 101
23. I. Lagny-Pourmir, A.-M. Lorinet, N. Yanaihara, and M. Laburthe Structural requirements for galanin interaction with receptors from pancreatic beta cells and from brain tissue of the rat Peptides 10 1989 757 761
24. R.J. Talalrida, R.B. Raffa, and P. McGonigle Radioligand binding. Direct binding. Hill plot R.J. tallarida R.B. Raffa P. McGonigle Principles in general pharmacology 1988 Springer New York 211 212 [chapter 9]
25. 2 in rat fundus strips Pharmacol Res 44 2001 47 51
26. D. Laurence, and J. Carpenter A dictionary of pharmacology and clinical drug evaluation 1994 UCL Press London p. 192
27. 2: a partial agonist at galanin receptors in rat isolated gastric fundus Pharmacology 55 1997 179 184