Administration-time-dependent effects of antihypertensive treatment on the circadian pattern of blood pressure

Current Opinion in Nephrology and Hypertension

Volumn 14, Issue 5, 2005, Pages 453-459

  Hermida, Ramón C ^a   Ayala, Diana E ^a   Calvo, Carlos ^b  

^a UNIVERSITY OF VIGO   (Spain)

^b Instituto de Salud Carlos III   (Spain)

Author keywords

Blood pressure; Chronotherapy; Dipper; Hypertension; Non dipper

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; BENAZEPRIL; CALCIUM CHANNEL BLOCKING AGENT; CAPTOPRIL; CILNIDIPINE; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXAZOSIN; ENALAPRIL; IMIDAPRIL; ISRADIPINE; NEBIVOLOL; NIFEDIPINE; NISOLDIPINE; NITRENDIPINE; PERINDOPRIL; QUINAPRIL; RAMIPRIL; TORASEMIDE; TRANDOLAPRIL; VALSARTAN;

BLOOD PRESSURE MONITORING; CHRONOTHERAPY; CIRCADIAN RHYTHM; DIET; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG SAFETY; EXERCISE; HUMAN; HYPERTENSION; KIDNEY FAILURE; MICROALBUMINURIA; NEPHROSCLEROSIS; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; SECOND MESSENGER; SYSTEMATIC REVIEW;

EID: 23844524535     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mnh.0000174144.07174.74     Document Type: Review

References (64)

1. Lemmer B. Cardiovascular chronobiology and chronopharmacology. In: Touitou Y, Haus E, editors. Biologic rhythms in clinical and laboratory medicine. Berlin: Springer-Verlag; 1992. pp. 418-427.
2. Hermida RC, Ayala DE, Fernández JR, et al. Modeling the circadian variability of ambulatorily monitored blood pressure by multiple-component analysis. Chronobiol Int 2002; 19:461-481.
3. Kario K, Pickering TG, Umeda Y, et al. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study. Circulation 2003; 107:1401-1406.
4. Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. JAMA 2003; 289:2560-2571.
5. O'Brien E, Sheridan J, O'Malley K. Dippers non-dippers [letter]. Lancet 1988; 13:397.
6. Verdecchia P, Porcellati C, Schillaci G, et al. Ambulatory blood pressure: an independent predictor of prognosis in essential hypertension. Hypertension 1994; 24:793-801.
7. Staessen JA, Thijs L, Fagard R, et al. Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. JAMA 1999; 282:539-546.
8. Ohkubo T, Hozawa A, Yamaguchi J, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J Hypertens 2002; 20:2183-2189.
9. Kikuya M, Ohkubo T, Asayama K, et al. Ambulatory blood pressure and 10-year risk of cardiovascular and noncardiovascular mortality. The Ohasama Study. Hypertension 2005; 45:240-245. This recent evaluation of the Ohasama study has indicated, after 10.8 years of follow up, that nighttime blood pressure has a better prognostic value of cardiovascular mortality than daytime blood pressure.
10. Hermida RC, Smolensky MH. Chronotherapy of hypertension. Curr Opin Nephrol Hypertens 2004; 13:501-505.
11. Portaluppi F, Smolensky MH. Circadian rhythm and environmental determinants of blood pressure regulation in normal and hypertensive conditions. In: White WB, editor. Blood pressure monitoring in cardiovascular medicine and therapeutics. Totowa, NJ: Humana Press; 2000. pp. 79-118.
12. Smolensky MH, Haus E. Circadian rhythms in clinical medicine with applications to hypertension. Am J Hypertens 2001; 14:2803-2905.
13. Lemmer B, Portaluppi F. Chronopharmacology of cardiovascular diseases. In: Redfern P, Lemmer B, editors. Physiology and pharmacology of biological rhythms. Heidelberg: Springer-Verlag; 1997. pp. 251-297.
14. Smolensky MH. Chronobiology and chronotherapeutics: applications to cardiovascular medicine. In: Deedwania PC, editor. Circadian rhythms of cardiovascular disorders. Armonk, NY: Futura Publishing Co; 1997 pp. 173-206.
15. Lemmer B. Cardiovascular chronobiology and chronopharmacology. Importance of timing of dosing. In: White WB, editor. Blood pressure monitoring in cardiovascular medicine and therapeutics. Totowa, NJ: Humana Press; 2000. pp. 255-271.
16. Labrecque G, Beauchamp D. Rhythms and pharmacokinetics. In: Redfern P, editor. Chronotherapeutics. London: Pharmaceutical Press; 2003. pp. 75-110.
17. Witte K, Lemmer B. Rhythms and pharmacodynamics. In: Redfern P, editor. Chronotherapeutics. London: Pharmaceutical Press; 2003. pp. 111-126.
18. Mengden T, Binswanger B, Gruene S. Dynamics of drug compliance and 24-hour blood pressure control of once daily morning vs evening amlodipine. J Hypertens 1992; 10(suppl 4):S136.
19. Nold G, Strobel G, Lemmer B. Morning vs evening amlodipine treatment: effect on circadian blood pressure profile in essential hypertensive patients. Blood Press Monit 1998; 3:17-25.
20. Hermida RC, Calvo C, Ayala DE, et al. Administration-time dependent effects of amlodipine on blood pressure in hypertensive patients. J Hypertens 2003; 21(suppl 4):S62-S63.
21. Qiu YG, Chen JZ, Zhu JH, Yao XY. Differential effects of morning or evening dosing of amlodipine on circadian blood pressure and heart rate. Cardiovasc Drugs Ther 2003; 17:335-341.
22. Calvo C, Hermida RC, Ayala DE, et al. Administration time-dependent effects on ambulatory blood pressure of amlodipine as added therapy in hypertensive patients. J Hypertens 2004; 22(suppl 2):S117.
23. Kitahara Y, Saito F, Akao M, et al. Effect of morning and bedtime dosing with cilnidipine on blood pressure, heart rate, and sympathetic nervous activity in essential hypertensive patients. J Cardiovasc Pharmacol 2004; 43: 68-73. Both morning and bedtime dosing with cilnidipine reduced the average SBP over 24 h, during daytime and during nighttime.
24. Kohno I, Iwasaki H, Okutani M, et al. Administration-time-dependent effects of diltiazem on the 24-hour blood pressure profile of essential hypertension patients. Chronobiol Int 1997; 14:71-84.
25. Fogari R, Malacco E, Tettamanti F, et al. Evening vs. morning isradipine sustained release in essential hypertension: a double-blind study with 24 h ambulatory monitoring. Br J Clin Pharmacol 1993; 35:51-54.
26. Portaluppi F, Vergnani L, Manfredini R, et al. Time-dependent effect of isradipine on the nocturnal hypertension in chronic renal failure. Am J Hypertens 1995; 8:719-726.
27. Greminger P, Suter PM, Holm D, et al. Morning versus evening administration of nifedipine gastrointestinal therapeutic system in the management of essential hypertension. Clin Invest 1994; 72:864-869.
28. Hermida RC, Calvo C, Ayala DE, et al. Administration time-dependent effects of nifedipine GITS on ambulatory blood pressure in patients with essential hypertension. Am J Hypertens 2005; 18:63A. In uncontrolled patients with 30 mg/day nifedipine, the efficacy of 60 mg/day was double after bedtime as compared to morning administration of the drug. Moreover, bedtime administration of nifedipine GITS reduced the incidence of edema by 91% and the total number of secondary effects by 74% as compared to morning dosing.
29. White WB, Mansoor GA, Pickering TG, et al. Differential effects of morning and evening dosing of nisoldipine ER on circadian blood pressure and heart rate. Am J Hypertens 1999; 12:806-814.
30. Meilhac B, Mallion JM, Carre A, et al. Study of the influence of the time of administration on the antihypertensive effect and nitrendipine tolerance in mild to moderate essential hypertensive patients. Value of ambulatory recording of blood pressure on 24 hours. Therapie 1992; 47:205-210.
31. Umeda T, Naomi S, Iwaoka T, et al. Timing for administration of an antihypertensive drug in the treatment of essential hypertension. Hypertension 1994; 23(suppl 1):I211-I214.
32. Palatini P, Mos L, Motolese M, et al. Effect of evening versus morning benazepril on 24-hour blood pressure: a comparative study with continuous intraarterial monitoring. Int J Clin Pharmacol Ther Toxicol 1993; 31:295-300.
33. Witte K, Weisser K, Neubeck M, et al. Cardiovascular effects, pharmacokinetics and converting enzyme inhibition of enalapril after morning versus evening administration. Clin Pharmacol Ther 1993; 54:177-186.
34. Morgan T, Anderson A, Jones E. The effect on 24 h blood pressure control of an angiotensin converting enzyme inhibitor (perindopril) administered in the morning or at night. J Hypertens 1997; 15:205-211.
35. Palatini P. Can an angiotensin-converting enzyme inhibitor with a short half-life effectively lower blood pressure for 24 hours? Am Heart J 1992; 123:1421-1425.
36. Palatini P, Racioppa A, Raule G, et al. Effect of timing of administration on the plasma ACE inhibitory activity and the antihypertensive effect of quinapril. Clin Pharmacol Ther 1992; 52:378-383.
37. Myburgh DP, Verho M, Botes JH, et al. 24-Hour pressure control with ramipril: comparison of once-daily morning and evening administration. Curr Ther Res 1995; 56:1298-1306.
38. Kuroda T, Kario K, Hoshide S, et al. Effects of bedtime vs. morning administration of the long-acting lipophilic angiotensin-converting enzyme inhibitor trandolapril on morning blood pressure in hypertensive patients. Hypertens Res 2004; 27:15-20. Results from this trial indicate that bedtime administration of the medication results in a safe and effective means of controlling morning blood pressure in hypertensive patients without inducing excessive nocturnal reduction.
39. Middeke M, Kluglich M, Holzgreve H. Chronopharmacology of captopril plus hydrochlorothiazide in hypertension: morning versus evening dosing. Chronobiol Int 1991; 8:506-510.
40. Kohnol, Ijiri H, Takusagawa M, et al. Effect of imidapril in dipper and nondipper hypertensive patients: comparison between morning and evening administration. Chronobiol Int 2000; 17:209-219.
41. Yusuf S, Sleight P, Pogue J, et al. Effects of an angiotensin-converting- enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients: the Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000; 342:145-153.
42. Svensson P, de Faire U, Sleight P, et al. Comparative effects of ramipril on ambulatory and office blood pressures. A HOPE substudy. Hypertension 2001; 38:e28-e32.
43. Panza JA, Epstein SE, Quyyumi AA. Circadian variation in vascular tone and its relation to alpha-sympathetic vasoconstrictor activity. N Engl J Med 1991; 325:986-990.
44. Pickering TG, Levenstein M, Walmsley P, for the Hypertension and Lipid Trial Study Group. Nighttime dosing of doxazosin has peak effect on morning ambulatory blood pressure. Results of the HALT study. Am J Hypertens 1994; 7:844-847.
45. Lemmer B, Nold G, Behne S, Kaiser R. Chronopharmacokinetics and cardiovascular effects of nifedipine. Chronobiol Int 1991; 8:485-494.
46. Langner B, Lemmer B. Circadian changes in the pharmacokinetics and cardiovascular effects of oral propranolol in healthy subjects. Eur J Clin Pharmacol 1988; 33:619-624.
47. Hermida RC, Calvo C, Ayala DE, et al. Administration-time-dependent effects of doxazosin GITS on ambulatory blood pressure of hypertensive subjects. Chronobiol Int 2004; 21:277-296. Doxazosin GITS ingested daily upon awakening failed to provide full 24-h therapeutic coverage, while bedtime dosing significantly reduced blood pressure throughout the entire 24 h, whether used alone as a monotherapy or in combination with other antihypertensive pharmacotherapy.
48. Guidelines Committee 2003 European Society of Hypertension. European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2003; 21:1011-1053.
49. Stanton A, O'Brien E. Effects of therapy on the circadian blood pressure profile [in German]. Kar-dio 1994; 3:1-8.
50. Lemmer B, Portaluppi F. Chronopharmacology of cardiovascular diseases. In: Redfern P, Lemmer B, editors. Handbook of experimental pharmacology, vol 125, Physiology and pharmacology of biological rhythms. Heidelberg: Springer-Verlag; 1997. pp. 251-297.
51. de Leeuw PW, Falke HE, Kho TL, et al. Effects of beta-agrenergic blockade on diurnal variability of blood pressure and plasma noradrenaline levels. Acta Med Scand 1977; 202:389-392.
52. Calvo C, Hermida RC, Ayala DE, et al. Effects of nebivolol monotherapy on ambulatory blood pressure in patients with grade 1-2 essential hypertension. J Hypertens 2004; 22(suppl 2):S386.
53. Hermida RC, Calvo C, Ayala DE, et al. Administration time-dependent effects of nebivolol on ambulatory blood pressure in patients with essential hypertension. Am J Hypertens 2005; 18:62-63. Independently of treatment time (awakening versus bedtime), efficacy of nebivolol was significantly greater on the diurnal than on the nocturnal blood-pressure mean, with a resulting decrease in the day/night blood-pressure ratio independent of dosing time.
54. Hermida RC, Calvo C, Ayala DE, et al. Administration time-dependent effects of valsartan on ambulatory blood pressure in hypertensive subjects. Hypertension 2003; 42:283-290.
55. Calvo C, Hermida RC, Ayala DE, et al. Effects of morning versus evening administration of valsartan on ambulatory blood pressure in elderly hypertensive patients. J Hypertens 2004; 22(suppl 2):S382. Results indicate that, in elderly hypertensive patients, mainly characterized by a diminished nocturnal decline in blood pressure, dosing time with valsartan might be chosen at bedtime, for improved efficacy during the nocturnal resting hours, and the potential reduction in cardiovascular risk associated with a normalized day/ night blood-pressure ratio.
56. Hermida RC, Calvo C, Ayala DE, et al. Administration time-dependent effects of valsartan on ambulatory blood pressure in nondipper hypertensive patients. J Hypertens 2004; 22(suppl 2):S243. Results from this trial in a selected population of non-dipper patients indicate that the day/night blood-pressure ratio was unchanged after valsartan on awakening. This ratio was significantly increased when valsartan was administered at bedtime, which resulted in 75% of the patients reverted to dippers, a significant increase in the percentage of patients with controlled blood pressure after treatment, and a significant reduction in urinary albumin excretion.
57. Calvo C, Hermida RC, Ayala DE, et al. Administration time-dependent effects of torasemide on ambulatory blood pressure in patients with essential hypertension. Am J Hypertens 2005; 18:52A. Efficacy of 5 mg/day torasemide was significantly higher after bedtime dosing as compared to the administration of the drug on awakening, without significantly increasing secondary effects.
58. Hermida RC, Ayala DE, Calvo C, et al. Administration-time dependent effects of aspirin on blood pressure in untreated hypertensive patients. Hypertension 2003; 41:1259-1267.
59. Hermida RC, Ayala DE, Calvo C, López JE. Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients. J Am Coll Cardiol 2005 (in press).
60. Timio M, Lolli S, Verdura C, et al. Circadian blood pressure changes in patients with chronic renal insufficiency: a prospective study. Ren Fail 1993; 15:231-237.
61. Bianchi S, Bigazzi R, Baldari G, et al. Diurnal variations of blood pressure and microalbuminuria in essential hypertension. Am J Hypertens 1994; 7:23-29.
62. Hermida RC, Calvo C, Ayala DE, et al. Relationship between physical activity and blood pressure in dipper and nondipper hypertensive patients. J Hypertens 2002; 20:1097-1104.
63. Parati G, Omboni S, Rizzoni D, et al. The smoothness index: a new, reproducible and clinically relevant measure of the homogeneity of the blood pressure reduction with treatment for hypertension. J Hypertens 1998; 16:1685-1691.
64. Hermida RC, Calvo C, Ayala DE, et al. Differing effects of awakening versus bedtime valsartan administration on urinary albumin excretion in hypertensive patients. Am J Hypertens 2005; 18:61A. Urinary albumin excretion was significantly reduced mainly after bedtime, but not morning, treatment with valsartan. This reduction was independent of the 24h blood-pressure decrease after treatment, but highly correlated with the decrease in the nocturnal mean of blood pressure, and mainly with the increase in day/night blood-pressure ratio associated to bedtime administration of valsartan.