The ontogeny of the urogenital system of the spotted hyena (Crocuta crocuta Erxleben)

Biology of Reproduction

Volumn 73, Issue 3, 2005, Pages 554-564

  Cunha, Gerald R ^a   Place, Ned J ^b   Baskin, Larry ^a   Conley, Alan ^c   Weldele, Mary ^b   Cunha, Tristan J ^a   Wang, Y Z ^d   Cao, Mei ^a   Glickman, Stephen E ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

Androgen receptor; Clitoris; Developmental biology; Female urogenital tract; Male urogenital tract; Penis; Spotted hyena; Testosterone

Indexed keywords

ALPHA ACTIN; ANDROGEN; ANDROGEN RECEPTOR; ANTIANDROGEN; RECEPTOR BLOCKING AGENT; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE;

ANATOMY; ANDROGEN METABOLISM; ANDROGEN RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARNIVORA; CLITORIS; CONTROLLED STUDY; DEVELOPMENTAL BIOLOGY; FEMALE; FEMALE GENITAL SYSTEM; FETUS; GESTATION PERIOD; MALE; MALE GENITAL SYSTEM; MUSCLE; NONHUMAN; ONTOGENY; ORGAN SIZE; OVARY; PENIS; PLACENTA; PREGNANCY; PRIORITY JOURNAL; PROSTATE; PROTEIN EXPRESSION; SEX DIFFERENCE; SPOTTED HYENA; TESTIS DEVELOPMENT; TUNICA ALBUGINEA; URETHRA; UROGENITAL SINUS; UROGENITAL SYSTEM; VIRILIZATION;

ANDROGEN ANTAGONISTS; ANIMALS; ENZYME INHIBITORS; FEMALE; FETUS; FINASTERIDE; FLUTAMIDE; GENITALIA, FEMALE; GENITALIA, MALE; HYAENIDAE; MALE; URINARY TRACT;

CROCUTA CROCUTA;

EID: 23844516093     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.105.041129     Document Type: Article

References (30)

1. Frank L, Glickman S, Powch I. Sexual dimorphism in the spotted hyaena (Crocuta crocuta). J Zool Lond 1990; 221:308-313.
2. Frank LG, Glickman SE. Giving birth through a penile clitoris: parturition and dystocia in the spotted hyaena (Crocuta crocuta). J Zool 1994; 234:659-665.
3. Watson M. On the female generative organs of Hyaena crocuta. Proc Zool Soc Lond 1877;369-379.
4. Matthews L. Reproduction of the spotted hyena (Crocuta crocuta Erxleben). Phil Trans Roy Soc Lond B 1939; 230:1-78.
5. Cunha GR, Wang Y, Place NJ, Liu W, Baskin L, Glickman SE. Urogenital system of the spotted hyena (Crocuta crocuta Erxleben): a functional histological study. J Morphol 2003; 256:205-218.
6. Jost A. Problems of fetal endocrinology: the gonadal and hypophyseal hormones. Rec Prog Horm Res 1953; 8:379-418.
7. Yamada G, Satoh Y, Baskin LS, Cunha GR. Cellular and molecular mechanisms of development of the external genitalia. Differentiation 2003; 71:445-460.
8. Burns RK. Role of hormones in the differentiation of sex. In: Young WC (ed.), Sex and Internal Secretions. Baltimore: Williams and Wilkins; 1961:76-158.
9. Short RV. Sex determination and differentiation. In: Austin CR, Short RV (eds.), Reproduction in Mammals, vol. 2. New York: Cambridge University Press; 1972:43-71.
10. Lindeque M, Skinner JD. Fetal androgens and sexual mimicry in spotted hyaenas (Crocuta crocuta). J Reprod Fertil 1982; 65:405-410.
11. Licht P, Hayes T, Tsai P, Cunha G, Kim H, Golbus M, Hayward S, Martin MC, Jaffe RB, Glickman SE. Androgens and masculinization of genitalia in the spotted hyaena (Crocuta crocuta). 1. Urogenital morphology and placental androgen production during fetal life. J Reprod Fertil 1998; 113:105-116.
12. Licht P, Frank LG, Pavgi S, Yalcinkaya TM, Siiteri PK, Glickman SE. Hormonal correlates of 'masculinization' in female spotted hyaenas (Crocuta crocuta). 2. Maternal and fetal steroids. J Reprod Fertil 1992; 95:463-474.
13. Yalcinkaya TM, Siiteri PK, Vigne JL, Licht P, Pavgi S, Frank LG, Glickman SE. A mechanism for virilization of female spotted hyenas in utero. Science 1993; 260:1929-1931.
14. Drea CM, Weldele ML, Forger NG, Coscia EM, Frank LG, Licht P, Glickman SE. Androgens and masculinization of genitalia in the spotted hyaena (Crocuta crocuta). 2. Effects of prenatal anti-androgens. J Reprod Fertil 1998; 113:117-127.
15. Forger NG, Frank LG, Breedlove SM, Glickman SE. Sexual dimorphism of perineal muscles and motoneurons in spotted hyenas. J Comp Neurol 1996; 375:333-343.
16. Drea CM, Place NJ, Weldele ML, Coscia EM, Licht P, Glickman SE. Exposure to naturally circulating androgens during foetal life incurs direct reproductive costs in female spotted hyenas, but is prerequisite for male mating. Proc R Soc Lond B Biol Sci 2002; 269:1981-1987.
17. Neaves WB, Griffin JE, Wilson JD. Sexual dimorphism of the phallus in spotted hyaena (Crocuta crocuta). J Reprod Fertil 1980; 59:509-513.
18. Place N, Weldele M, Wahaj S. Ultrasonic measurements of second and third trimester fetuses to predict gestational age and date of parturition in captive and wild hyenas Crocuta crocuta. Theriogenology 2002; 58:1047-1055.
19. Wang Y, Hayward SW, Donjacour AA, Young P, Jacks T, Sage J, Dahiya R, Cardiff R, Day ML, Cunha GR. Hormonal carcinogenesis of the Rb-knockout mouse prostate. Cancer Res 2000; 60:6008-6017.
20. Fraser D, Thompson BK. Armed sibling rivalry among suckling piglets. Behav Ecol Sociobiol 1991; 29:9-15.
21. Kaminski MA, Corbin CJ, Conley AJ. Development and differentiation of the interstitial and tubular compartments of fetal porcine testes. Biol Reprod 1999; 60:119-127.
22. Ford JJ, Christenson RK, Maurer RR. Serum testosterone concentrations in embryonic and fetal pigs during sexual differentiation. Biol Reprod 1980; 23:583-587.
23. Jost A, Vigier B, Prepin J, Perchellet JP. Studies on sex differentiation in mammals. Recent Prog Horm Res 1973; 29:1-41.
24. Wilson J, George F, Griffin J. The hormonal control of sexual development. Science 1981; 211:1278-1284.
25. Chevallier A, Kieny M, Mauger A, Sengel P. Developmental fate of the somitic mesoderm in the chick embryo. In: Ede DD, Hinchliffe JR, Balls M (eds.), Vertebrate Limb and Somite Morphogenesis. London: Cambridge University Press; 1977:421-432.
26. Shellswell GB, Wolpert L. The pattern of muscle and tendon development in the chick wing. In: Ede DD, Hinchliffe JR, Balls M (eds.), Vertebrate Limb and Somite Morphogenesis. London: Cambridge University Press; 1977:72-86.
27. Place NJ, Glickman SE. Masculinization of female mammals: lessons from nature. Adv Exp Med Biol 2004; 545:243-253.
28. Renfree MB, Short RV. Sex determination in marsupials: evidence for a marsupial-eutherian dichotomy. Philos Trans R Soc Lond B Biol Sci 1988; 322:41-53.
29. Arnold AP. Genetically triggered sexual differentiation of brain and behavior. Horm Behav 1996; 30:495-505.
30. Arnold AP, Rissman EF, De Vries GJ. Two perspectives on the origin of sex differences in the brain. Ann N Y Acad Sci 2003; 1007:176-188.