Similitude of brain perfusion pattern in hypothyroidism and early Alzheimer's disease: Physiopathologic considerations [1]

Journal of Nuclear Medicine

Volumn 46, Issue 7, 2005, Pages 1247-

  Guedj, Eric ^a   Taïeb, David ^a   De Laforte, Catherine ^a   Ceccaldi, Mathieu ^a   Mundler, Olivier ^a  

^a TIMONE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

THYROID HORMONE; THYROXINE;

ALZHEIMER DISEASE; AMNESIA; BRAIN DYSFUNCTION; BRAIN PERFUSION; BRAIN REGION; DISEASE SEVERITY; HUMAN; HYPOTHYROIDISM; LETTER; NERVE CELL PLASTICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ADULT; BRAIN; BRAIN CIRCULATION; COMPARATIVE STUDY; DIFFERENTIAL DIAGNOSIS; DRUG EFFECT; FEMALE; METHODOLOGY; MIDDLE AGED; NOTE; PROGNOSIS; SCINTISCANNING; TREATMENT OUTCOME; VASCULARIZATION;

ADULT; ALZHEIMER DISEASE; BRAIN; CEREBROVASCULAR CIRCULATION; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; HYPOTHYROIDISM; MIDDLE AGED; PROGNOSIS; THYROXINE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TREATMENT OUTCOME;

EID: 23844506891     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (5)

1. Krausz Y, Freedman N, Lester H, et al. Regional cerebral blood flow in patients with mild hypothyroidism. J Nucl Med. 2004;45:1712-1715.
2. Burmeister LA, Ganguli M, Dodge HH, Toczek T, DeKosky ST, Nebes RD. Hypothyroidism and cognition: preliminary evidence for a specific defect in memory. Thyroid. 2001;11:1177-1185.
3. Matsuda H, Kitayama N, Ohnishi T, et al. Longitudinal evaluation of both morphologic and functional changes in the same individuals with Alzheimer's disease. J Nucl Med. 2002;43:304-311.
4. Meguro K, Blaizot X, Kondoh Y, LeMestric C, Baron JC, Chavoix C. Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET: implications for Alzheimer's disease. Brain. 1999;122:1519-1531.
5. Gilbert ME, Paczkowshi C. Propylthiouracil (PTU)-induced hypothyroidism in the developing rat impairs synaptic transmission and plasticity in the dentate gyrus of the adult hippocampus. Brain Res Dev Brain Res. 2003;145:19-29.