3D imaging of microscopic structures using a proton beam

IEEE Transactions on Nuclear Science

Volumn 52, Issue 3 I, 2005, Pages 612-617

  Michelet Habchi, C ^a   Incerti, S ^a   Aguer, P ^a   Barberet, Ph ^a   Gontier, E ^a   Guinefolleau, T ^a   Moretto, Ph ^a   Pouthier, A ^a   Pouthier, T ^a   Smith, R W ^a  

^a CENTRE DE CALCUL DE L INSTITUT NATIONAL DE PHYSIQUE NUCLEAIRE ET DE PHYSIQUE DES PARTICULES   (France)

Author keywords

Cell structure; Computed tomography; Ion microtomography; Nuclear microprobe; Scanning transmission ion microscopy

Indexed keywords

ALGORITHMS; ATTENUATION; BIOMEDICAL ENGINEERING; FLUORESCENCE; ION BEAMS; MICROMETERS; SYNCHROTRONS; TOMOGRAPHY; TUMORS;

CELL STRUCTURE; ION-MICROTOMOGRAPHY; NUCLEAR MICROPROBES; SCANNING TRANSMISSION ION MICROSCOPY;

IMAGING TECHNIQUES;

EID: 23844503627     PISSN: 00189499     EISSN: None     Source Type: Journal    
DOI: 10.1109/TNS.2005.851411     Document Type: Article

References (18)

1. W. Baumeister, R. Grimm, and J. Walz, "Electron tomography of molecules and cells," Trends Cell Biol., vol. 9, pp. 81-85, 1999.
2. R. D. Leapman, E. Kocsis, G. Zhang, T. L. Talbot, and P. Laquerriere, "Three-dimensional distributions of elements in biological samples by energy-filtered electron tomography," Ultramicroscopy, vol. 100, pp. 115-125, 2004.
3. B. Golosio, A. Simionovici, A. Somogyi, L. Lemelle, M. Chukalina, and A. Brunetti, "Internal elemental microanalysis combining x-ray fluorescence, compton, and transmission tomography," J. Appl. Phys., vol. 94, no. 1, pp. 145-156, 2003.
4. A. M. Cormack and A. M. Koehler, "Quantitative proton tomography: Preliminary experiments," Phys. Med. Biol., vol. 21/4, pp. 560-569, 1976.
5. A. E. Pontau, A. J. Antolak, D. H. Morse, A. A. Ver Berkmoes, J. M. Brase, D. W. Heikkinen, H. E. Martz, and I. D. Proctor, "Ion microbeam tomography," Nucl. Instrum. Methods Phys. Res. B, vol. 40/41, pp. 646-650, 1989.
6. B. E. Fischer and C. Mühlbauer, "Microtomography by heavy ions," Nucl. Instrum. Methods Phys. Res. B, vol. 47, pp. 271-282, 1990.
7. R.M.S. Schofield and H. W. Lefevre, "PIXE-STIM microtomography: Zinc and manganese concentrations in a scorpion stinger," Nucl. Instrum. Methods Phys. Res. B, vol. 72, pp. 104-110, 1992.
8. C. Michelet and Ph. Moretto, "Three-dimensional mapping of individual cells using a proton microbeam," Nucl. Instrum. Methods Phys. Res. B, vol. 150, pp. 173-178, 1999.
9. _, "STIM Tomography at the cell level," Nucl. Instrum. Methods Phys. Res. B, vol. 158, pp. 361-367, 1999.
10. R. Ortega, P. Moretto, A. Fajac, J. Bénard, Y. Llabador, and M. Simonoff, "Quantitative mapping of platinum and essential trace metal in cisplatin resistant and sensitive human ovarian adenocarcinoma cells," Cell Mol. Blol., vol. 42/1, pp. 77-88, 1996.
11. Y. Llabador and Ph. Moretto, Applications of Nuclear Microprobes in the Life Sciences, Singapore: World Scientific, 1998.
12. J. C. Overley, R. M. S. Schofield, J. D. MacDonald, and J. H. Lefevre, "Energy-loss image formation in scanning transmission ion microscopy," Nucl. Instrum. Methods Phys. Res. B, vol. 30, pp. 337-341, 1988.
13. H. W. Lefevre, R. M. S. Schofield, J. C. Overley, and J. D. MacDonald, "Scanning transmission ion microscopy as it complements particle induced x-ray emission microanalysis," Scanning Micros., vol. 1, pp. 879-889, 1987.
14. L. R. Doolittle, "Algorithms for the rapid simulation of rutherford backscattering spectra," Nucl. Instrum. Methods Phys. Res. B, vol. 9, pp. 344-351, 1985.
15. H. H. Andersen and J. F. Ziegler, Stopping Powers and Ranges in All Elements. New York: Pergamon, 1977, vol. 3 et 4.
16. S. G. Azevedo, D. J. Schneberk, J. P. Fitch, and H. E. Martz, "Calculation of the rotational centers in computed tomography sinograms," IEEE Trans. Nucl. Sci., vol. 37, no. 4, pp. 1525-1540, Aug. 1990.
17. R. H. Huesman, G. T. Gullberg, W. L. Greenberg, and T. F. Budinger, RECLBL Library Users Manual: Donner Algorithms for Reconstruction Tomography. Berkeley, CA: Lawrence Berkeley Laboratory, 1977. Pub. 214.
18. S. Agostinelli et al. (2003) GEANT4 - A simulation toolkit. Nucl. Instrum. Methods Phys. Res. A [Online], pp. 250-303. Available: http://geant4.web.cern.ch/